1.3.1.14: dihydroorotate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.3.1.14

Reaction

(S)-dihydroorotate
+
NAD+
=
Orotate
+
NADH
+
H+

Synonyms

b-type dihydroorotate dehydrogenase, DHO dehydrogenase, DHODase, DHOdehase A, dihydro-orotic dehydrogenase, dihydroorotate dehydrogenase, dihydrorotate dehydrogenase B, L-5,6-dihydro-orotate:NAD oxidoreductase, More, orotate reductase, reductase, orotate

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.14 dihydroorotate dehydrogenase (NAD+)

Inhibitors

Inhibitors on EC 1.3.1.14 - dihydroorotate dehydrogenase (NAD+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(R,R)-5-benzyl-3-(1-carboxy-2-phenylethyl)hydantoin
-
-
(S)-5-benzyl-3-carboxymethylhydantoin
-
-
(S)-N-carboxymethyl-N'-(1-carboxy-2-phenylethyl)urea
-
-
(S,S)-5-benzyl-3-(1-carboxy-2-phenylethyl)hydantoin
-
-
(S,S)-N,N'-bis(1-carboxy-2-phenylethyl)urea
-
-
(S,S)-N-(1-carboxyethyl)-N'-(1-carboxy-2-phenylethyl)urea
-
4 mM, 20% inhibition
1,10-phenanthroline
-
1 mM, 10% inhibition
2,4-Dihydroxy-6-methyl pyrimidine
-
-
3-carboxymethylhydantoin
-
-
5-benzyl-3-(1-carboxy-2-phenylethyl)-1-methylhydantoin
-
-
5-Benzyl-3-(1-carboxy-2-phenylethyl)hydantoin
-
time-dependent irreversible inhibition at the active site, mechanism
5-Methylorotate
-
2 mM, 50% inhibition of reduction of orotate
Acriflavin
-
partial inhibition
Barbituric acid
-
-
cysteine
-
inhibitory above 7 mM
Hg2+
complete inhibition of both orotate reductase and NADH oxidase reaction
hydantoin
-
derived from alpha-amino acids, weak competitive inhibitors, compounds with a benzyl goup are better inhibitors
isopropyl hydantoin
-
-
KCN
complete inhibition of orotate reductase reaction
N,N'-bis(carboxymethyl)urea
-
-
Na3PO4
-
0.2 M, at pH 6.5, 20% inhibition
NaCl
-
0.2 M, 55% inhibition
p-chloromercuribenzoate
phosphate
-
high concentrations
Quinacrine
19.2% inhibition of orotate reductase reaction
additional information
-
not inhibited by 0.01 M arsenite
-