1.3.1.124: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
This is an abbreviated version!
For detailed information about 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], go to the full flat file.
Reaction
Synonyms
2,4-dienoyl coenzyme A reductase, 2,4-dienoyl-CoA reductase, 4-enoyl-CoA reductase, DCR, DECR, DECR1, DECR2, DELTA2,DELTA4-dienoyl-CoA reductase, More, pDCR, SPS19
ECTree
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Reaction
Reaction on EC 1.3.1.124 - 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
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reaction mechanism, E276 is the proton donor in catalysis
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a (2E)-2-enoyl-CoA + NADP+ = a (2E,4E)-2,4-dienoyl-CoA + NADPH + H+
reaction mechanism, enzyme-ligand interactions in a distinctive short-chain reductase active site, catalytic site structure, stabilization of the dienolate reaction intermediate by Tyr199 and Asn148, and NADP+, overview
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