1.3.1.124: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

This is an abbreviated version!
For detailed information about 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], go to the full flat file.

Word Map on EC 1.3.1.124

Reaction

a (2E)-2-enoyl-CoA
+
NADP+
=
a (2E,4E)-2,4-dienoyl-CoA
+
NADPH
+
H+

Synonyms

2,4-dienoyl coenzyme A reductase, 2,4-dienoyl-CoA reductase, 4-enoyl-CoA reductase, DCR, DECR, DECR1, DECR2, DELTA2,DELTA4-dienoyl-CoA reductase, More, SPS19

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.124 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

Engineering

Engineering on EC 1.3.1.124 - 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D117A
-
site-directed mutagenesis, mutant is expressed in inclusion bodies and cannot be refolded to a functional enzyme after extraction from inclusion bodies with 8 M urea as denatured protein
D300A
-
site-directed mutagenesis, reduced activity and altered kinetics compared to the wild-type enzyme
E154A
-
site-directed mutagenesis, reduced activity and altered kinetics compared to the wild-type enzyme
E227A
-
site-directed mutagenesis, reduced activity and altered kinetics compared to the wild-type enzyme
E276A
-
site-directed mutagenesis, reduced activity and altered kinetics compared to the wild-type enzyme
E310A
-
site-directed mutagenesis, effects on reaction mechanism
E310Q
-
site-directed mutagenesis, effects on reaction mechanism
K214A
-
site-directed mutagenesis, effects on reaction mechanism
N148A
-
site-directed mutagenesis, effects on reaction mechanism
S210A
-
site-directed mutagenesis, effects on reaction mechanism
T197A
-
site-directed mutagenesis, effects on reaction mechanism
Y199A
-
site-directed mutagenesis, effects on reaction mechanism
additional information