1.3.1.124: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

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For detailed information about 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], go to the full flat file.

Reaction

Synonyms

2,4-dienoyl coenzyme A reductase, 2,4-dienoyl-CoA reductase, 4-enoyl-CoA reductase, DCR, DECR, DECR1, DECR2, DELTA2,DELTA4-dienoyl-CoA reductase, More, pDCR, SPS19

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.124 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

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Results	in table
7	Activating Compound
3076	AA Sequence
2	Application
8	Cloned(Commentary)
18	Cofactor
1	Crystallization (Commentary)
31	Disease/ Diagnostics
5	Expression
14	General Information
3	Inhibitors
26	KM Value [mM]
31	Localization
7	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
205	Organism
5	Pathway
6	pH Optimum
14	Protein Variants
13	Purification (Commentary)
5	Reaction
1	Reaction Type
39	Reference
1	Renatured (Commentary)
33	Source Tissue
28	Specific Activity [micromol/min/mg]
1	Storage Stability
48	Substrates and Products (Substrate)
10	Subunits
41	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Disease

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Disease on EC 1.3.1.124 - 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Breast Neoplasms

Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.

17636013

Carcinogenesis

Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.

17636013

Gastritis

Comparative study of gastric cancer and chronic gastritis via network analysis.

30425814

Neoplasm Metastasis

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis.

32686647

Neoplasms

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.

32427840

Neoplasms

Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.

17636013

Neoplasms

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis.

32686647

Neoplasms

Sugar and fat - that's where it's at: metabolic changes in tumors.

18304378

Non-alcoholic Fatty Liver Disease

Protein interaction mapping interpretation of none alcoholic fatty liver disease model of rats after fat diet feeding.

29511485

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