1.3.1.115: 3-oxocholoyl-CoA 4-desaturase

This is an abbreviated version!
For detailed information about 3-oxocholoyl-CoA 4-desaturase, go to the full flat file.

Reaction

Synonyms

3-oxo-DELTA4-cholenoic acid oxidoreductase, BaiCD

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.115 3-oxocholoyl-CoA 4-desaturase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	Cofactor
2	General Information
8	Natural Substrates/ Products (Substrates)
4	Organism
2	Pathway
1	pH Optimum
1	Purification (Commentary)
2	Reaction
3	Reference
12	Substrates and Products (Substrate)
3	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 1.3.1.115 - 3-oxocholoyl-CoA 4-desaturase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

6 entries

7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

6 entries

7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens

P19410

-

744383

-

-

?

7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens

P19410

the enzyme participates in the bile acid 7alpha-dehydroxylation pathway

744383

-

-

?

7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens

P19410

the enzyme catalyses the stereo-specific oxidation of its substrates and has no activity with the 7beta anomer

744383

-

-

?

7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens JCM 10418

-

-

744383

-

-

?

7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens VPI 12708

P19410

the enzyme participates in the bile acid 7alpha-dehydroxylation pathway

744383

-

-

?

7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens VPI 12708

P19410

the enzyme catalyses the stereo-specific oxidation of its substrates and has no activity with the 7beta anomer

744383

-

-

?

7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens

P19410

-

744383

-

-

?

7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens

P19410

the enzyme participates in the bile acid 7alpha-dehydroxylation pathway

744383

-

-

?

7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens

P19410

the enzyme catalyses the stereo-specific oxidation of its substrates and has no activity with the 7beta anomer

744383

-

-

?

7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens JCM 10418

-

-

744383

-

-

?

7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens VPI 12708

P19410

the enzyme participates in the bile acid 7alpha-dehydroxylation pathway

744383

-

-

?

7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+

7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+

[Clostridium] scindens VPI 12708

P19410

the enzyme catalyses the stereo-specific oxidation of its substrates and has no activity with the 7beta anomer

744383

-

-

?