1.3.1.108: caffeoyl-CoA reductase

This is an abbreviated version!
For detailed information about caffeoyl-CoA reductase, go to the full flat file.

Word Map on EC 1.3.1.108

Reaction

3-(3,4-dihydroxyphenyl)propanoyl-CoA
+ 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster =
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA
+ 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster

Synonyms

caffeoyl-CoA reductase-Etf complex, electron-bifurcating caffeoyl-CoA reductase, hydrocaffeoyl-CoA:NAD+, ferredoxin oxidoreductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.108 caffeoyl-CoA reductase

Systematic Name

Systematic Name on EC 1.3.1.108 - caffeoyl-CoA reductase

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SYSTEMATIC NAME
IUBMB Comments
3-(3,4-dihydroxyphenyl)propanoyl-CoA:NAD+, ferredoxin oxidoreductase
The enzyme, characterized from the bacterium Acetobacterium woodii, contains two [4Fe-4S] clusters and FAD. The enzyme couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. It also reduces 4-coumaroyl-CoA and feruloyl-CoA.