1.3.1.105: 2-methylene-furan-3-one reductase

This is an abbreviated version!
For detailed information about 2-methylene-furan-3-one reductase, go to the full flat file.

Reaction

4-hydroxy-2,5-dimethylfuran-3(2H)-one
+
NADP+
=
4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one
+
NADPH
+
H+

Synonyms

FaEO, SIEO

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.105 2-methylene-furan-3-one reductase

Substrates Products

Substrates Products on EC 1.3.1.105 - 2-methylene-furan-3-one reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADH + H+
2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NAD+
show the reaction diagram
(2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADH + H+
4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NAD+
show the reaction diagram
(2E)-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADH + H+
2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NAD+
show the reaction diagram
(2E)-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+
2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + 5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone + NADP+
show the reaction diagram
-
-
-
?
4-hydroxy-5-methyl-2-methylene-3(2H)-furanone + NADH + H+
(2R)-4-hydroxy-2,5-dimethyl-3(2H)-furanone + NAD+
show the reaction diagram
kcat/Km for NADH is 7.5fold lower than for NADPH, Re-specific, i.e. the 4R-hydride of NAD(P)H is transferred
-
-
?
4-hydroxy-5-methyl-2-methylene-3(2H)-furanone + NADH + H+
4-hydroxy-2,5-dimethyl-3(2H)-furanone + NAD+
show the reaction diagram
4-hydroxy-5-methyl-2-methylene-3(2H)-furanone + NADPH + H+
(2R)-4-hydroxy-2,5-dimethyl-3(2H)-furanone + NADP+
show the reaction diagram
kcat/Km for NADH is 7.5fold lower than for NADPH, Re-specific, i.e. the 4R-hydride of NAD(P)H is transferred
-
-
?
4-hydroxy-5-methyl-2-methylene-3(2H)-furanone + NADPH + H+
4-hydroxy-2,5-dimethyl-3(2H)-furanone + NADP+
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
?
additional information
?
-