1.3.1.100: chanoclavine-I aldehyde reductase

This is an abbreviated version!
For detailed information about chanoclavine-I aldehyde reductase, go to the full flat file.

Reaction

dihydrochanoclavine-I aldehyde
+
NADP+
=
chanoclavine-I aldehyde
+
NADPH
+
H+

Synonyms

EasA, FgaOx3, old yellow enzyme

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.100 chanoclavine-I aldehyde reductase

Systematic Name

Systematic Name on EC 1.3.1.100 - chanoclavine-I aldehyde reductase

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SYSTEMATIC NAME
IUBMB Comments
chanoclavine-I aldehyde:NAD+ oxidoreductase
Contains FMN. The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The enzyme catalyses the reduction of chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde. This hydrolyses spontaneously to form 6,8-dimethyl-6,7-didehydroergoline, which is converted to festuclavine by EC 1.5.1.44, festuclavine dehydrogenase.