1.2.99.6: carboxylate reductase
This is an abbreviated version!
For detailed information about carboxylate reductase, go to the full flat file.
Word Map on EC 1.2.99.6
-
1.2.99.6
-
aldose
-
reductases
-
nadph-dependent
-
aldo-keto
-
aflatoxin
-
1.1.1.2
-
desulfovibrio
-
akr1a1
-
polyols
-
d-glucuronate
-
sorbinil
-
dihydrodiols
-
gigas
-
afars
-
dl-glyceraldehyde
-
alpha-hydroxysteroids
-
furfural
-
molybdenum-containing
-
3-deoxyglucosone
-
phosphopantetheinylation
-
ethoxyquin
-
high-km
-
trans-dihydrodiols
-
tungsten-containing
-
gamma-hydroxybutyrate
-
tolrestat
-
propionaldehyde
-
molybdopterin
-
oltipraz
-
sporobolomyces
-
epalrestat
-
pterins
-
5-hydroxymethylfurfural
-
l-gulonate
-
p-nitrobenzaldehyde
-
hexonate
- 1.2.99.6
- aldose
- reductases
-
nadph-dependent
-
aldo-keto
- aflatoxin
-
1.1.1.2
- desulfovibrio
- akr1a1
- polyols
- d-glucuronate
- sorbinil
-
dihydrodiols
- gigas
-
afars
- dl-glyceraldehyde
-
alpha-hydroxysteroids
- furfural
-
molybdenum-containing
- 3-deoxyglucosone
-
phosphopantetheinylation
- ethoxyquin
-
high-km
-
trans-dihydrodiols
-
tungsten-containing
- gamma-hydroxybutyrate
- tolrestat
- propionaldehyde
- molybdopterin
- oltipraz
- sporobolomyces
- epalrestat
- pterins
- 5-hydroxymethylfurfural
- l-gulonate
- p-nitrobenzaldehyde
-
hexonate
Reaction
Synonyms
aldehyde ferredoxin oxidoreductase, aldehyde oxidoreductase, aldehyde reductase, AOR, BV-AIDH, Carboxylic acid reductase, Carboxylic acid reductase/aldehyde reductase, Reductase, carboxylate, W-AOR
ECTree
1.2.99.6 carboxylate reductaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.2.99.6 - carboxylate reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3,4-Dimethoxy-5-hydroxy-benzaldehyde + carbamoyl methyl viologen
3,4-Dimethoxy-5-hydroxy-benzoate + reduced carbamoyl methyl viologen
-
-
-
-
?
3,5-Dimethoxy-4-hydroxy-benzaldehyde + carbamoyl methyl viologen
3,5-Dimethoxy-4-hydroxy-benzoate + reduced carbamoyl methyl viologen
-
-
-
-
?
3-Chlorobenzoate + reduced carbamoyl methyl viologen
3-Chlorobenzaldehyde + carbamoyl methyl viologen
3-Fluorobenzoate + reduced carbamoyl methyl viologen
3-Fluorobenzaldehyde + carbamoyl methyl viologen
3-Hydroxybenzoate + reduced carbamoyl methyl viologen
3-Hydroxybenzaldehyde + carbamoyl methyl viologen
3-Methoxybenzoate + reduced carbamoyl methyl viologen
3-Methoxybenzaldhyde + carbamoyl methyl viologen
3-Methylbenzoate + reduced carbamoyl methyl viologen
3-Methylbenzaldehyde + carbamoyl methyl viologen
4-(Hydroxymethyl)benzoate + reduced carbamoyl methyl viologen
4-(Hydroxymethyl)benzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Chlorobenzoate + reduced carbamoyl methyl viologen
4-Chlorobenzaldehyde + carbamoyl methyl viologen
4-Fluorobenzoate + reduced carbamoyl methyl viologen
4-Fluorobenzaldehyde + carbamoyl methyl viologen
4-Hydroxy-3-methoxy-benzaldehyde + carbamoyl methyl viologen
4-Hydroxy-3-methoxy-benzoate + reduced carbamoyl methyl viologen
-
-
-
-
?
4-Hydroxybenzaldehyde + carbamoyl methyl viologen
4-Hydroxybenzoate + reduced carbamoyl methyl viologen
-
r
-
?
4-Hydroxybenzoate + reduced carbamoyl methyl viologen
4-Hydroxybenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Methoxybenzaldehyde + benzyl viologen
4-Methoxybenzoate + reduced carbamoyl methyl viologen
4-Methoxybenzoate + reduced carbamoyl methyl viologen
4-Methoxybenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Methylbenzoate + reduced carbamoyl methyl viologen
4-Methylbenzaldehyde + carbamoyl methyl viologen
5-Phenyl-2,4-pentadienate + reduced carbamoyl methyl viologen
? + carbamoyl methyl viologen
-
-
-
-
?
Acetaldehyde + 2,6-dichlorophenol-indophenol
acetate + reduced 2,6-dichlorophenol-indophenol
Acetaldehyde + 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
acetate + reduced 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
acetaldehyde + benzyl viologen
acetic acid + reduced benzyl viologen
-
-
-
-
?
Acetaldehyde + carbamoyl methyl viologen
acetate + reduced carbamoyl methyl viologen
-
r
-
?
acetaldehyde + methyl viologen + H2O
acetate + reduced methyl viologen
-
-
-
-
r
benzaldehyde + 2,6-dichlorophenol indophenol
benzoate + reduced 2,6-dichlorophenol indophenol
Megalodesulfovibrio gigas
-
-
-
-
?
benzaldehyde + benzyl viologen
benzoic acid + reduced benzyl viologen
-
96% of activity compared to acetaldehyde
-
-
?
Cinnamaldehyde + carbamoyl methyl viologen
Cinnamate + reduced carbamoyl methyl viologen
-
r
-
?
crotonaldehyde + benzyl viologen
crotonic acid + reduced benzyl viologen
-
47% of activity compared to acetaldehyde
-
-
?
Crotonaldehyde + benzyl viologen
E-2-Butenoate + reduced benzyl viologen
-
at less than 1% of the activity with benzyl viologen
-
-
?
Crotonaldehyde + ES-1 ferredoxin
Crotonate + reduced ES-1 ferredoxin
-
-
-
-
?
decylaldehyde + 2,6-dichlorophenol indophenol
decanoate + reduced 2,6-dichlorophenol indophenol
Megalodesulfovibrio gigas
-
-
-
-
?
DL-glyceraldehyde + benzyl viologen
alpha,beta-dihydroxypropionic acid + reduced benzyl viologen
-
9% of activity compared to acetaldehyde
-
-
?
formaldehyde + benzyl viologen
formic acid + reduced benzyl viologen
-
2% of activity compared to acetaldehyde
-
-
?
Furfural + benzyl viologen
2-Furancarboxylic acid + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 77% of the activity relative to acetaldehyde
-
-
?
Glutaraldehyde + benzyl viologen
Glutarate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 16% of the activity relative to acetaldehyde
-
-
?
glutaraldehyde + benzyl viologen
glutaric acid + reduced benzyl viologen
-
19% of activity compared to acetaldehyde
-
-
?
Glyceraldehyde + benzyl viologen
Glycerate + reduced benzyl viologen
-
-
-
-
?
Glyceraldehyde + methyl viologen
Glycerate + reduced methyl viologen
-
-
-
-
?
Glycolaldehyde + benzyl viologen
Glycolate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 23% of the activity relative to acetaldehyde
-
-
?
glyoxylate + benzyl viologen
oxalic acid + reduced benzyl viologen
-
6% of activity compared to acetaldehyde
-
-
?
Hexanal + benzyl viologen
Hexanoate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 6% of the activity relative to acetaldehyde
-
-
?
isovaleraldehyde + benzyl viologen
isopentanoic acid + reduced benzyl viologen
-
66% of activity compared to acetaldehyde
-
-
?
Methanal + carbamoyl methyl viologen
Formate + reduced methyl viologen
-
-
-
-
?
Methanal + methyl viologen
Formate + reduced carbamoyl methyl viologen
-
-
-
-
?
octanal + 2,6-dichlorophenol indophenol
octanoate + reduced 2,6-dichlorophenol indophenol
Megalodesulfovibrio gigas
-
-
-
-
?
Pentanal + benzyl viologen
Pentanoate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 9% of the activity relative to acetaldehyde
-
-
?
phenylacetaldehyde + benzyl viologen
phenylacetic acid + reduced benzyl viologen
-
20% of activity compared to acetaldehyde
-
-
?
Propanal + reduced 1,1',2,2'-tetramethylviologen
Propanoate + 1,1',2,2'-tetramethylviologen
-
-
-
-
?
propionaldehyde + benzyl viologen
propionic acid + reduced benzyl viologen
-
119% of activity compared to acetaldehyde
-
-
?
Pyridine 4-carboxylate + reduced carbamoyl methyl viologen
Pyridine 4-carboxaldehyde + carbamoyl methyl viologen
-
-
-
-
?
salicylaldehyde + benzyl viologen
salicylic acid + reduced benzyl viologen
-
4% of activity compared to acetaldehyde
-
-
?
terephthalaldehyde + carbamoyl methyl viologen
terephthalate + reduced carbamoyl methyl viologen
-
r
-
?
3-Chlorobenzoate + reduced carbamoyl methyl viologen
3-Chlorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Chlorobenzoate + reduced carbamoyl methyl viologen
3-Chlorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Fluorobenzoate + reduced carbamoyl methyl viologen
3-Fluorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Fluorobenzoate + reduced carbamoyl methyl viologen
3-Fluorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Hydroxybenzoate + reduced carbamoyl methyl viologen
3-Hydroxybenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Hydroxybenzoate + reduced carbamoyl methyl viologen
3-Hydroxybenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Methoxybenzoate + reduced carbamoyl methyl viologen
3-Methoxybenzaldhyde + carbamoyl methyl viologen
-
-
-
-
?
3-Methoxybenzoate + reduced carbamoyl methyl viologen
3-Methoxybenzaldhyde + carbamoyl methyl viologen
-
-
-
-
?
3-Methylbenzoate + reduced carbamoyl methyl viologen
3-Methylbenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
3-Methylbenzoate + reduced carbamoyl methyl viologen
3-Methylbenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Chlorobenzoate + reduced carbamoyl methyl viologen
4-Chlorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Chlorobenzoate + reduced carbamoyl methyl viologen
4-Chlorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Fluorobenzoate + reduced carbamoyl methyl viologen
4-Fluorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Fluorobenzoate + reduced carbamoyl methyl viologen
4-Fluorobenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Methoxybenzaldehyde + benzyl viologen
4-Methoxybenzoate + reduced carbamoyl methyl viologen
Megalodesulfovibrio gigas
-
at 19% of the activity relative to acetaldehyde
-
-
?
4-Methoxybenzaldehyde + benzyl viologen
4-Methoxybenzoate + reduced carbamoyl methyl viologen
-
-
-
?
4-Methylbenzoate + reduced carbamoyl methyl viologen
4-Methylbenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
4-Methylbenzoate + reduced carbamoyl methyl viologen
4-Methylbenzaldehyde + carbamoyl methyl viologen
-
-
-
-
?
Acetaldehyde + 2,6-dichlorophenol-indophenol
acetate + reduced 2,6-dichlorophenol-indophenol
Megalodesulfovibrio gigas
-
at 1.3% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + 2,6-dichlorophenol-indophenol
acetate + reduced 2,6-dichlorophenol-indophenol
Megalodesulfovibrio gigas NCIMB 9332
-
at 1.3% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
acetate + reduced 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
Megalodesulfovibrio gigas
-
at 5% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
acetate + reduced 3-(4',5'-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide
Megalodesulfovibrio gigas NCIMB 9332
-
at 5% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + benzyl viologen
acetate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
-
-
-
?
Acetaldehyde + benzyl viologen
acetate + reduced benzyl viologen
Megalodesulfovibrio gigas NCIMB 9332
-
-
-
-
?
Acetaldehyde + benzyl viologen
acetate + reduced benzyl viologen
-
r
-
-
?
Acetaldehyde + benzyl viologen
acetate + reduced benzyl viologen
-
r
-
-
?
Acetaldehyde + methyl viologen
acetate + reduced methyl viologen
Megalodesulfovibrio gigas
-
at 19% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + methyl viologen
acetate + reduced methyl viologen
Megalodesulfovibrio gigas NCIMB 9332
-
at 19% of the activity relative to benzyl viologen
-
-
?
Acetaldehyde + methyl viologen
acetate + reduced methyl viologen
-
-
-
-
?
Benzaldehyde + benzyl viologen
Benzoate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 93% of the activity relative to acetaldehyde
-
-
?
Benzaldehyde + benzyl viologen
Benzoate + reduced benzyl viologen
Megalodesulfovibrio gigas NCIMB 9332
-
at 93% of the activity relative to acetaldehyde
-
-
?
Benzaldehyde + benzyl viologen
Benzoate + reduced benzyl viologen
-
-
-
-
?
Benzaldehyde + benzyl viologen
Benzoate + reduced benzyl viologen
-
-
-
-
?
Benzaldehyde + carbamoyl methyl viologen
Benzoate + reduced carbamoyl methyl viologen
-
-
-
-
?
Benzaldehyde + carbamoyl methyl viologen
Benzoate + reduced carbamoyl methyl viologen
-
only reverse reaction described
-
-
?
Benzaldehyde + carbamoyl methyl viologen
Benzoate + reduced carbamoyl methyl viologen
-
r
-
?
Butanal + NH2CO-methyl viologen
Butanoate + reduced NH2CO-methyl viologen
-
-
-
-
?
Butanal + NH2CO-methyl viologen
Butanoate + reduced NH2CO-methyl viologen
-
only reverse reaction described
-
-
?
Butanal + NH2CO-methyl viologen
Butanoate + reduced NH2CO-methyl viologen
-
-
-
-
?
Butyraldehyde + benzyl viologen
Butanoate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 16% of the activity relative to acetaldehyde
-
-
?
Butyraldehyde + benzyl viologen
Butanoate + reduced benzyl viologen
-
101% of activity compared to acetaldehyde
-
-
?
Crotonaldehyde + methyl viologen
Crotonate + reduced methyl viologen
-
-
-
-
?
Crotonaldehyde + methyl viologen
Crotonate + reduced methyl viologen
-
-
-
-
?
Indoleacetaldehyde + benzyl viologen
Indoleacetate + reduced benzyl viologen
-
-
-
-
?
Indoleacetaldehyde + benzyl viologen
Indoleacetate + reduced benzyl viologen
-
-
-
-
?
Isovaleraldehyde + benzyl viologen
Isovalerate + reduced benzyl viologen
-
-
-
-
?
Isovaleraldehyde + benzyl viologen
Isovalerate + reduced benzyl viologen
-
-
-
-
?
Isovaleraldehyde + benzyl viologen
Isovalerate + reduced benzyl viologen
-
-
-
-
?
Methanal + benzyl viologen
Formate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 16% of the activity relative to acetaldehyde
-
-
?
Phenylacetaldehyde + benzyl viologen
Phenylacetate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 31% of the activity relative to acetaldehyde
-
-
?
Phenylacetaldehyde + benzyl viologen
Phenylacetate + reduced benzyl viologen
-
-
-
-
?
Phenylacetaldehyde + benzyl viologen
Phenylacetate + reduced benzyl viologen
-
-
-
-
?
Phenylacetaldehyde + benzyl viologen
Phenylacetate + reduced benzyl viologen
-
-
-
-
?
Propanal + benzyl viologen
Propanoate + reduced benzyl viologen
-
only reverse reaction described
-
?
Propanal + benzyl viologen
Propanoate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 117% of the activity relative to acetaldehyde
-
-
?
Propanal + methyl viologen
Propanoate + reduced methyl viologen
-
only reverse reaction described
-
?
Propanal + methyl viologen
Propanoate + reduced methyl viologen
-
-
-
-
?
Propanal + NH2CO-methyl viologen
Propanoate + reduced carbamoyl methyl viologen
-
-
-
-
?
Propanal + NH2CO-methyl viologen
Propanoate + reduced carbamoyl methyl viologen
-
only reverse reaction described
-
?
Propanal + NH2CO-methyl viologen
Propanoate + reduced carbamoyl methyl viologen
-
r
-
-
?
Salicylaldehyde + benzyl viologen
Salicylate + reduced benzyl viologen
Megalodesulfovibrio gigas
-
at 14% of the activity relative to acetaldehyde
-
-
?
Salicylaldehyde + benzyl viologen
Salicylate + reduced benzyl viologen
-
-
-
-
?
additional information
?
-
-
in contast to the dimeric enzyme form the heptameric enzyme form also catalyzes the reversible reduction of the oxidized carbamoyl methyl viologen with NADPH
-
-
?
additional information
?
-
-
its physiological role is proposed as the oxidation of glyceraldehyde to glycerate in a unique, partially nonphosphorylated glycolytic pathway that generates acetyl-CoA from glucose without participation of nicotinamide nucleotides
-
-
?
additional information
?
-
-
the enzyme possibly functions to oxidize aldehydes generated during amino acid catabolism, it is also possible that the enzyme generates aldehydes from organic acids produced by fermentation
-
-
?
additional information
?
-
-
the enzyme possibly functions to oxidize aldehydes generated during amino acid catabolism, it is also possible that the enzyme generates aldehydes from organic acids produced by fermentation
-
-
?
additional information
?
-
-
the enzyme possibly functions to oxidize aldehydes generated during amino acid catabolism, it is also possible that the enzyme generates aldehydes from organic acids produced by fermentation
-
-
?
