1.2.7.7: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)

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For detailed information about 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin), go to the full flat file.

Reaction

Synonyms

2-ketoisovalerate ferredoxin oxidoreductase, 2-oxoisovalerate ferredoxin reductase, 2-oxoisovalerate oxidoreductase, 2-oxoisovalerate:ferredoxin oxidoreductase, 3-methyl-2-oxobutanoate dehydrogenase, 3-methyl-2-oxobutanoate synthase (ferredoxin), branched-chain ketoacid ferredoxin reductase, branched-chain oxo acid ferredoxin reductase, keto-valine-ferredoxin oxidoreductase, ketoisovalerate ferredoxin reductase, VOR

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.7 With an iron-sulfur protein as acceptor

                1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)

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10	Activating Compound
1629	AA Sequence
4	Application
1	CAS Registry Number
2	Cloned(Commentary)
2	Cofactor
2	Inhibitors
28	KM Value [mM]
9	Metals/Ions
26	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
27	Organism
2	Oxidation Stability
14	Pathway
3	pH Optimum
1	pH Stability
7	Purification (Commentary)
16	Reaction
2	Reaction Type
19	Reference
7	Specific Activity [micromol/min/mg]
121	Substrates and Products (Substrate)
12	Subunits
16	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
24	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.2.7.7 - 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)

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SYSTEMATIC NAME

IUBMB Comments

3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)

The enzyme is CoA-dependent and contains thiamine diphosphate and iron-sulfur clusters. Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo-pentanoate, and 2-oxobutanoate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that reversibly catalyse the oxidative decarboxylation of different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase, and EC 1.2.7.3, 2-oxoglutarate synthase.