1.2.7.4: anaerobic carbon-monoxide dehydrogenase
This is an abbreviated version!
For detailed information about anaerobic carbon-monoxide dehydrogenase, go to the full flat file.
Word Map on EC 1.2.7.4
-
1.2.7.4
-
co2
-
codhs
-
nickel
-
acetogenic
-
thermoaceticum
-
rubrum
-
rhodospirillum
-
methanosarcina
-
carboxydothermus
-
hydrogenoformans
-
carboxidovorans
-
c-clusters
-
oligotropha
-
wood-ljungdahl
-
co-dependent
-
methanogenesis
-
carboxydotrophic
-
co-oxidizing
-
hydrogenases
-
barkeri
-
sulfate-reducing
-
nickel-dependent
-
acetobacterium
-
nifes
-
molybdenum-containing
-
hydrogenogenic
-
acetogenesis
-
nickel-containing
-
syngas
-
methyl-coenzyme
-
moorella
-
square-planar
-
homoacetogenic
-
overpotential
-
acetate-grown
-
fe-containing
-
electrocatalysts
-
analysis
-
hydrogenophaga
-
methyltetrahydrofolate
-
cubane-type
- 1.2.7.4
- co2
-
codhs
- nickel
-
acetogenic
- thermoaceticum
- rubrum
- rhodospirillum
- methanosarcina
- carboxydothermus
- hydrogenoformans
- carboxidovorans
-
c-clusters
-
oligotropha
-
wood-ljungdahl
-
co-dependent
-
methanogenesis
-
carboxydotrophic
-
co-oxidizing
- hydrogenases
- barkeri
-
sulfate-reducing
-
nickel-dependent
- acetobacterium
-
nifes
-
molybdenum-containing
-
hydrogenogenic
-
acetogenesis
-
nickel-containing
-
syngas
-
methyl-coenzyme
- moorella
-
square-planar
-
homoacetogenic
-
overpotential
-
acetate-grown
-
fe-containing
-
electrocatalysts
- analysis
-
hydrogenophaga
- methyltetrahydrofolate
-
cubane-type
Reaction
Synonyms
acetyl coenzyme A synthase/carbon monoxide dehydrogenase, acetyl-CoA synthase/carbon monoxide dehydrogenase, ACS/CODH, Carbon dioxide/carbon monoxide oxidoreductase, Carbon monoxide dehydrogenase, carbon monoxide dehydrogenase-corrinoid enzyme complex, carbon monoxide dehydrogenase/acetyl-CoA synthase, Carbon monoxide oxidoreductase, Cdh, CO dehydrogenase, CO dehydrogenase complex, CO dehydrogenase complex II, CO dehydrogenase II, CO dehydrogenase/acetyl-CoA synthase, Co-DG, CO-DH, CODH, CODH II, CODH-II, CODH/ACS, CODHACS, CODHase, CODHII, coos, Dehydrogenase, carbon monoxide, EC 1.2.99.2, monoxide dehydrogenase/acetyl-CoA synthase, Ni,Fe-CODH, Ni,Fe-dependent carbon monoxide dehydrogenase, Ni-CODH, Ni-containing carbon monoxide dehydrogenase, Ni-Fe carbon monoxide dehydrogenase II
ECTree
1.2.7.4 anaerobic carbon-monoxide dehydrogenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.2.7.4 - anaerobic carbon-monoxide dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-SCoA + CO
acetyl-SCoA + CO
-
acetyl-CoA/CO exchange reaction, 14C experiments prove that the enzyme can cleave both the carbon-carbon and carbon-sulfur bonds of acetyl-CoA as well as to store methyl, CO, and CoA fragments at the active site
-
r
acetyl-SCoA + CoASH
acetyl-SCoA + CoASH
-
acetyl-CoA/CoA exchange reaction
-
r
CO + ferredoxin
?
-
ferredoxin is the direct electron acceptor, the carbon-monoxide dehydrogenase complex reduces a ferredoxin which, together with membranes and associated hydrogenase, reconstitutes a CO-oxidizing:H2-evolving system
-
-
?
CO + H2O + 1,1'-trimethylene-4,4'-dimethyl-2,2'dipyridylium dibromide
CO2 + reduced 1,1'-trimethylene-4,4'-dimethyl-2,2'dipyridylium dibromide
-
-
-
?
CO + H2O + 2 oxidized ferredoxin
CO2 + 2 reduced ferredoxin + 2 H+
-
-
-
-
r
CO + H2O + 2,3,5-triphenyltetrazolium chloride
CO2 + reduced 2,3,5-triphenyltetrazolium chloride
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO + H2O + acceptor
CO2 + reduced acceptor + H+
-
-
-
?
CO + H2O + cytochrome c3
CO2 + reduced cytochrome c3
-
cytochrome 3 from Desulfovibrio vulgaris
-
?
CO + H2O + electron acceptor
CO2 + reduced electron acceptor
-
a proton gradient across the cytoplasmic membrane is generated by channeling the electrons formed via cytochrome b561 into a CO-insensitive respiratory chain
-
?
CO + H2O + oxidized 2,3,5-triphenyltetrazolium chloride
CO2 + reduced 2,3,5-triphenyltetrazolium chloride
-
-
-
-
?
CO + H2O + oxidized 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO + H2O + oxidized cytochrome b
CO2 + reduced cytochrome b
-
membrane-bound b-type, native electron carrier
-
-
?
CO + H2O + oxidized cytochrome c3
CO2 + reduced cytochrome c3
-
Desulfovibrio vulgaris cytochrome c3
-
-
?
CO + H2O + oxidized methylene blue
CO2 + reduced methylene blue
-
-
-
-
?
CO + H2O + oxidized phenazine methosulfate
CO2 + reduced phenazine methosulfate
-
-
-
-
?
CO + H2O + oxidized rubredoxin
CO2 + reduced rubredoxin
-
most efficient electron acceptor
-
-
?
CO + H2O + phenazine methosulfate
CO2 + reduced phenazine methosulfate
-
-
-
?
CO2 + 2 reduced ferredoxin + 2 H+
CO + H2O + 2 oxidized ferredoxin
-
-
-
-
r
propionyl-SCoA + CoASH
propionyl-SCoA + CoASH
-
acetyl-CoA/CoA exchange reaction
-
r
trichloroethylene + ?
cis-dichloroethylene + trans-dichlororethylene + 1,1-dichloroethylene + vinyl chloride + ethylene
-
-
-
?
CO + H2O + 2,3,5-triphenyltetrazolium chloride
CO2 + reduced 2,3,5-triphenyltetrazolium chloride
-
-
-
?
CO + H2O + 2,3,5-triphenyltetrazolium chloride
CO2 + reduced 2,3,5-triphenyltetrazolium chloride
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
-
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
Mycobacterium sp. DSM 3803 / JC1
-
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
-
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
Mycobacterium tuberculosis H37Ra / ATCC 25177
-
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
Mycobacterium tuberculosis TMC 326 / H37Ra-INH-R / ATCC 35835
-
-
-
-
?
CO + H2O + 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
-
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
r
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
?
CO + H2O + acceptor
CO2 + reduced acceptor
-
-
-
-
r
CO + H2O + acceptor
CO2 + reduced acceptor
D5G1Y2; D5G1Y0; D5G1Y1
-
-
-
?
CO + H2O + coenzyme F420
CO2 + reduced coenzyme F420
-
-
-
?
CO + H2O + coenzyme F420
CO2 + reduced coenzyme F420
-
1.5% of the activity with methyl viologen
-
?
CO + H2O + electron acceptor
?
-
the physiological role of the enzyme in acetyl-CoA synthesis is the reduction of CO2 to a bound CO, the physiological electron acceptor is not known and may be different in different organisms
-
-
?
CO + H2O + electron acceptor
?
-
key enzyme in C1-pathway of acetyl-CoA degradation
-
-
?
CO + H2O + electron acceptor
?
Autotrophic methanogenic bacterium
-
the enzyme is required for autotrophic CO2 fixation in methanogens, the enzyme is also involved in methanogenesis from acetate, not required for methanogenesis
-
-
?
CO + H2O + electron acceptor
?
-
the carbon monoxide dehydrogenase-corrinoid enzyme complex catalyzes the methylation of tetrahydrosarcinapterin in a reaction involving net cleavage of acetyl-CoA
-
-
?
CO + H2O + electron acceptor
?
-
enzyme may also be involved in the formation of acetyl-CoA from methanol in methanogens
-
-
?
CO + H2O + electron acceptor
?
-
extensive role of the enzyme in the acetyl-CoA pathway, it is proposed that the enzyme serves as the CO, CH3, SCoA acceptor and catalyzes the final steps of the synthesis of acetyl-CoA
-
-
?
CO + H2O + electron acceptor
?
-
the enzyme is involved in the Wood pathway of acetyl-CoA synthesis
-
-
?
CO + H2O + electron acceptor
?
-
delivery of a low-potential electron to the CO-bound NiFe complex is the physiological function of the CO oxidation reaction catalyzed by the enzyme
-
-
?
CO + H2O + electron acceptor
?
-
the formation of acetyl-CoA from methyltetrahydrofolate requires several enzymes, including CO dehydrogenase
-
-
?
CO + H2O + electron acceptor
?
-
ferredoxin and a membrane-bound b-type cytochrome are considered to be the native electron carriers
-
-
?
CO + H2O + electron acceptor
?
-
catalyzes the final step in the synthesis of acetyl-CoA
-
-
?
CO + H2O + electron acceptor
?
-
the physiological role of the enzyme in acetyl-CoA synthesis is the reduction of CO2 to a bound CO, the physiological electron acceptor is not known and may be different in different organisms
-
-
?
CO + H2O + electron acceptor
?
-
key role of the enzyme in the synthesis of acetyl-CoA
-
-
?
CO + H2O + FAD
CO2 + FADH2
-
at 15% of the specific activity compared to methyl viologen
-
-
?
CO + H2O + FAD
CO2 + FADH2
-
at 15% of the specific activity compared to methyl viologen
-
-
?
CO + H2O + FAD
CO2 + FADH2
-
0.3% of the activity with methyl viologen
-
?
CO + H2O + ferredoxin
CO2 + reduced ferredoxin
-
active with ferredoxin obtained from Clostridium thermoaceticum, no activity with ferredoxin from spinach
-
?
CO + H2O + FMN
CO2 + FMNH2
-
at 15% of the specific activity compared to methyl viologen
-
-
?
CO + H2O + FMN
CO2 + FMNH2
-
at 15% of the specific activity compared to methyl viologen
-
-
?
CO + H2O + FMN
CO2 + FMNH2
-
0.6% of the activity with methyl viologen
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
r
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
catalyzes an exchange reaction between CO and the carbonyl group of acetyl-CoA
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
r
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
optimal concentration of CO 5% in headspace
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
Carboxydothermus hydrogenoformans Z-2901 / DSM 6008
-
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
no activity with NAD+ and NADP+
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
the enzyme fails to reduce NAD+, NADP+, or 8-hydroxy-5-deazaflavin cofactor 420
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
r
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
catalyzes the exchange reaction between coenzyme A and acetyl-CoA
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
catalyzes the exchange reaction between coenzyme A and acetyl-CoA
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
catalyzes the exchange reaction between propionyl-CoA and CoA at 7% of the exchange with acetyl-CoA
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
catalyzes at a low rate an exchange between CO2 and the carbonyl group of acetyl-CoA
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
no activity with FAD, NAD+ and NADP+
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
catalyzes the synthesis of acetyl-CoA from methyl corrinoid, Co and CoASH
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
catalyzes reversible decarbonylation of acetyl-CoA with retention of stereochemistry at the methyl group
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
catalyzes an exchange reaction between CO and the carbonyl group of acetyl-CoA
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
catalyzes an exchange reaction between CO and the carbonyl group of acetyl-CoA
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methyl viologen
CO2 + reduced methyl viologen
-
-
-
?
CO + H2O + methylene blue
CO2 + reduced methylene blue
-
-
-
?
CO + H2O + NAD+
CO2 + NADH + H+
-
the specific activity is increased by approximately 20% with NAD+ as the electron acceptor compared to methyl viologen
-
-
?
CO + H2O + NAD+
CO2 + NADH + H+
-
the specific activity is increased by approximately 20% with NAD+ as the electron acceptor compared to methyl viologen
-
-
?
CO + H2O + NADP+
CO2 + NADPH + H+
-
the specific activity is increased by approximately 20% with NADP+ as the electron acceptor compared to methyl viologen
-
-
?
CO + H2O + NADP+
CO2 + NADPH + H+
-
the specific activity is increased by approximately 20% with NADP+ as the electron acceptor compared to methyl viologen
-
-
?
CO + H2O + oxidized 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
-
-
-
-
?
CO + H2O + oxidized 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
D5G1Y2; D5G1Y0; D5G1Y1
-
-
-
?
CO + H2O + oxidized 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
-
-
-
-
?
CO + H2O + oxidized 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
CO2 + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium chloride
D5G1Y2; D5G1Y0; D5G1Y1
-
-
-
?
CO + H2O + oxidized ferredoxin
CO2 + reduced ferredoxin
-
may participate in methanogenesis by cleavage of acetate, reverse of the reaction in acetate biosynthesis
-
-
?
CO + H2O + oxidized ferredoxin
CO2 + reduced ferredoxin
-
-
-
-
?
CO + H2O + oxidized ferredoxin
CO2 + reduced ferredoxin
-
ferredoxin I and II
-
-
?
CO + H2O + oxidized ferredoxin
CO2 + reduced ferredoxin
-
ferredoxin from Clostridium pasteurianum is also a substrate
-
-
?
CO + H2O + oxidized ferredoxin
CO2 + reduced ferredoxin
-
acetate biosynthesis pathway, catalyzes an exchange reaction between CO and the carbonyl group of acetyl-CoA
-
-
?
CO + H2O + oxidized ferredoxin
CO2 + reduced ferredoxin
-
initial step of CO metabolism in acetogenic bacteria
-
-
?
CO + H2O + oxidized ferredoxin
CO2 + reduced ferredoxin + H+
-
-
-
-
?
CO + H2O + oxidized ferredoxin
CO2 + reduced ferredoxin + H+
-
-
-
-
?
CO + H2O + oxidized flavodoxin
CO2 + reduced flavodoxin
-
-
-
-
?
CO + H2O + oxidized methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
?
CO + H2O + oxidized methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
?
CO + H2O + oxidized methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
?
CO + H2O + oxidized methyl viologen
CO2 + reduced methyl viologen
-
no enzyme with cofactor F420
-
-
?
CO + H2O + oxidized methyl viologen
CO2 + reduced methyl viologen
-
no enzyme with cofactor F420
-
-
?
CO + H2O + oxidized methyl viologen
CO2 + reduced methyl viologen
-
-
-
-
?
CO + H2O + oxidized methyl viologen
CO2 + reduced methyl viologen + H+
-
-
-
-
?
CO + H2O + oxidized methyl viologen
CO2 + reduced methyl viologen + H+
-
-
-
-
?
CO + H2O + rubredoxin
CO2 + reduced rubredoxin
-
most efficient electron acceptor
-
?
CO + H2O + rubredoxin
CO2 + reduced rubredoxin
-
most efficient electron acceptor
-
?
tetrahydrosarcinapterin + acetyl-SCoA + H2O
methyltetrahydrosarcinapterin + CO2 + CoASH
-
-
-
?
tetrahydrosarcinapterin + acetyl-SCoA + H2O
methyltetrahydrosarcinapterin + CO2 + CoASH
-
carbon monoxide dehydrogenase-corrinoid enzyme complex, enzyme complex functions in synthesis of acetyl-CoA
-
r
additional information
?
-
-
enzyme fails to reduce NAD+, NADP+ or the 8-hydroxy-5-deazaflavin factor F420
-
-
?
additional information
?
-
-
pure enzyme has no hydrogenase or formate dehydrogenase activity
-
-
?
additional information
?
-
-
spinach ferredoxin, FAD, NAD+ and NADP+ are not reduced
-
-
?
additional information
?
-
-
Thermacetogenium phaeum operates the CO dehydrogenase/acetyl-CoA pathway reversibly both in acetate oxidation and in reductive acetogenesis by using the same biochemical apparatus
-
-
?
