1.2.4.4: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

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For detailed information about 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), go to the full flat file.

Reaction

Synonyms

2-oxoisocaproate dehydrogenase, 2-oxoisovalerate dehydrogenase, 2-oxoisovalerate dehydrogenase (lipoate), 2-oxoisovalerate dehydrogenase subunit alpha, alpha-keto-beta-methylvalerate dehydrogenase, alpha-ketoacid dehydrogenase, alpha-ketoisocaproate dehydrogenase, alpha-ketoisocaproic dehydrogenase, alpha-ketoisocaproic-alpha-keto-beta-methylvaleric dehydrogenase, alpha-ketoisovalerate dehydrogenase, alpha-oxoisocaproate dehydrogenase, BCDH, BCKA dehydrogenase, BCKADC, BCKD, BCKDC, BCKDH, BCKDH E1-alpha, BCKDH E1-beta, BCKDHA, BCKDHB, BCKDHc, BCOA, BCOAD, BDKG, Bkd, bkdF, branched chain alpha-ketoacid dehydrogenase complex, branched chain keto acid dehydrogenase, branched-chain (-2-oxoacid BCD) dehydrogenase, branched-chain 2-keto acid dehydrogenase, branched-chain 2-oxo acid dehydrogenase, branched-chain alpha-keto acid decarboxylase/dehydrogenase, branched-chain alpha-keto acid dehydrogenase, branched-chain alpha-keto acid dehydrogenase complex, branched-chain alpha-keto acid dehydrogenase E1beta subunit, branched-chain alpha-ketoacid dehydrogenase, branched-chain alpha-ketoacid dehydrogenase complex, branched-chain alpha-ketoacid dehydrogenase enzyme complex, branched-chain alpha-ketoacid dehydrogenase multienzyme complex, branched-chain alpha-oxo acid dehydrogenase, branched-chain keto acid dehydrogenase, branched-chain keto acid dehydrogenase complex, branched-chain ketoacid dehydrogenase, branched-chain ketoacid dehydrogenase E1, dehydrogenase, 2-oxoisocaproate, dehydrogenase, 2-oxoisovalerate (lipoate), dehydrogenase, branched chain alpha-keto acid, DHalpha, dihydrolipoyl acyl-transferase, dihydrolipoyl transacylase, E1b, E1b component, E1b component of the 2-oxo acid dehydrogenase complex, E2, EC 1.2.4.3, More

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.4 With a disulfide as acceptor

                1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

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Results	in table
77	Activating Compound
13945	AA Sequence
9	Application
2	CAS Registry Number
25	Cloned(Commentary)
125	Cofactor
7	Crystallization (Commentary)
532	Disease/ Diagnostics
5	Expression
9	General Information
2	General Stability
48	Inhibitors
15	Ki Value [mM]
91	KM Value [mM]
27	Localization
15	Metals/Ions
40	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
189	Organism
5	Pathway
95	PDB ID
8	pH Optimum
2	Posttranslational Modification
44	Protein Variants
30	Purification (Commentary)
8	Reaction
5	Reaction Type
100	Reference
2	Renatured (Commentary)
93	Source Tissue
20	Specific Activity [micromol/min/mg]
7	Storage Stability
178	Substrates and Products (Substrate)
30	Subunits
129	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Stability [°C]
26	Turnover Number [1/s]

General Stability

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General Stability on EC 1.2.4.4 - 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

maximum solubilization with minimum inactivation at 44 mM perchlorate carefully timed for 13 min

Oryctolagus cuniculus

-

349072

when saturated with thiamin diphosphate, the multienzyme complex is more stable to heat and chymotrypsin inactivation

Bos taurus

-

349075