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1.2.1.99: 4-(gamma-glutamylamino)butanal dehydrogenase

This is an abbreviated version!
For detailed information about 4-(gamma-glutamylamino)butanal dehydrogenase, go to the full flat file.

Reaction

4-(gamma-L-glutamylamino)butanal
+
NAD(P)+
 +
H2O
=
4-(gamma-L-glutamylamino)butanoate
 +
NAD(P)H
 +
H+

Synonyms

ALDH, gamma-Glu-gamma-aminobutyraldehyde dehydrogenase, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [NAD(P)+], NAD+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase, PuuC

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.99 4-(gamma-glutamylamino)butanal dehydrogenase

Cloned

Cloned on EC 1.2.1.99 - 4-(gamma-glutamylamino)butanal dehydrogenase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloned into Escherichia coli BL21 under the T5 promoter using the pQE-80L vector
expressed in Escherichia coli
-
PuuC of Klebsiella pneumoniae alone or with coenzyme B12-dependent glycerol dehydratase, DhaB overexpressed homologously, and two major oxidoreductases, DhaT and YqhD, disrupted resulting in KpC_DELTA_dhaT_DELTA_yqhD strain and KpBC_DELTA_dhaT_DELTA_yqhD strain, overexpressing the glycerol dehydratase DhaB, too
-
the recombinant strain SH254 producing 3-hydroxypropionate from glycerol is developed by cloning of dhaB and aldH genes in Escherichia coli BL21 under different regulatory promoters