1.2.1.95: L-2-aminoadipate reductase

This is an abbreviated version!
For detailed information about L-2-aminoadipate reductase, go to the full flat file.

Word Map on EC 1.2.1.95

Reaction

(S)-2-amino-6-oxohexanoate
+
holo-[LYS2 peptidyl-carrier-protein]
+
NADP+
=
L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein]
+
NADPH
+
H+

Synonyms

AAR, alpha-AAR, alpha-aminoadipate reductase, L-alpha-aminoadipic acid reductase, Lys1+, LYS2, Nps3

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.95 L-2-aminoadipate reductase

Systematic Name

Systematic Name on EC 1.2.1.95 - L-2-aminoadipate reductase

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SYSTEMATIC NAME
IUBMB Comments
(S)-2-amino-6-oxohexanoate:NADP+ oxidoreductase (ATP-forming)
This enzyme, characterized from the yeast Saccharomyces cerevisiae, catalyses the reduction of L-2-aminoadipate to (S)-2-amino-6-oxohexanoate during L-lysine biosynthesis. An adenylation domain activates the substrate at the expense of ATP hydrolysis, and forms L-2-aminoadipate adenylate, which is attached to a peptidyl-carrier protein (PCP) domain. Binding of NADPH results in reductive cleavage of the acyl-S-enzyme intermediate, releasing (S)-2-amino-6-oxohexanoate. Different from EC 1.2.1.31, L-aminoadipate-semialdehyde dehydrogenase, which catalyses a similar transformation in the opposite direction without ATP hydrolysis.