1.2.1.95: L-2-aminoadipate reductase

This is an abbreviated version!
For detailed information about L-2-aminoadipate reductase, go to the full flat file.

Word Map on EC 1.2.1.95

Reaction

(S)-2-amino-6-oxohexanoate
+
holo-[LYS2 peptidyl-carrier-protein]
+
NADP+
=
L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein]
+
NADPH
+
H+

Synonyms

AAR, alpha-AAR, alpha-aminoadipate reductase, L-alpha-aminoadipic acid reductase, Lys1+, LYS2, Nps3

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.95 L-2-aminoadipate reductase

Substrates Products

Substrates Products on EC 1.2.1.95 - L-2-aminoadipate reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
L-2-aminoadipate + NADPH + H+ + ATP
show the reaction diagram
-
presence of ATP and Mg2+ required
-
-
?
adipate + NADPH + H+ + ATP
adipate semialdehyde + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
?
D-2-aminoadipate + NADPH + H+ + ATP
(R)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
?
L-2-aminoadipate + NADPH + H+ + ATP
(S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
show the reaction diagram
S-carboxymethyl-L-cysteine + NADPH + H+ + ATP
? + NADP+ + AMP + diphosphate
show the reaction diagram
-
20fold lower activity than with L-2-aminoadipate
-
-
?
S-carboxymethyl-L-cysteine + NADPH + H+ + ATP
S-formylmethyl-L-cysteine + NADP+ + AMP + diphosphate
show the reaction diagram
-
-
-
?
additional information
?
-