1.2.1.95: L-2-aminoadipate reductase

This is an abbreviated version!
For detailed information about L-2-aminoadipate reductase, go to the full flat file.

Word Map on EC 1.2.1.95

Reaction

(S)-2-amino-6-oxohexanoate
+
holo-[LYS2 peptidyl-carrier-protein]
+
NADP+
=
L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein]
+
NADPH
+
H+

Synonyms

AAR, alpha-AAR, alpha-aminoadipate reductase, L-alpha-aminoadipic acid reductase, Lys1+, LYS2, Nps3

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.95 L-2-aminoadipate reductase

Engineering

Engineering on EC 1.2.1.95 - L-2-aminoadipate reductase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A459G
106% of the alpha-aminoadipate reductase activity of wild-type enzyme
A475G
109% of the alpha-aminoadipate reductase activity of wild-type enzyme
A979G
94% of the alpha-aminoadipate reductase activity of wild-type enzyme
D461E
4% of the alpha-aminoadipate reductase activity of wild-type enzyme
D461N
no alpha-aminoadipate reductase activity
D466E
15% of the alpha-aminoadipate reductase activity of wild-type enzyme
E420T
101% of the alpha-aminoadipate reductase activity of wild-type enzyme
F415Y
71% of the alpha-aminoadipate reductase activity of wild-type enzyme
F452L
6% of the alpha-aminoadipate reductase activity of wild-type enzyme
F452V
45% of the alpha-aminoadipate reductase activity of wild-type enzyme
F468L
96% of the alpha-aminoadipate reductase activity of wild-type enzyme
F982L
4% of the alpha-aminoadipate reductase activity of wild-type enzyme
F982V
no alpha-aminoadipate reductase activity
G418A
31% of the alpha-aminoadipate reductase activity of wild-type enzyme
G418V
no alpha-aminoadipate reductase activity
G421A
75% of the alpha-aminoadipate reductase activity of wild-type enzyme
G425A
99% of the alpha-aminoadipate reductase activity of wild-type enzyme
G474A
41% of the alpha-aminoadipate reductase activity of wild-type enzyme
G881E
conserved residue in the posttranslational activation domain LGGHSI, less than 50% of wild-type activity
G882R
conserved residue in the posttranslational activation domain LGGHSI, loss of activity
G882S
conserved residue in the posttranslational activation domain LGGHSI, loss of activity
G978A
2% of the alpha-aminoadipate reductase activity of wild-type enzyme
G978S
no alpha-aminoadipate reductase activity
G981A
no alpha-aminoadipate reductase activity
G981V
no alpha-aminoadipate reductase activity
G984A
3% of the alpha-aminoadipate reductase activity of wild-type enzyme
G984S
no alpha-aminoadipate reductase activity
H460R
no alpha-aminoadipate reductase activity
H883R
conserved residue in the posttranslational activation domain LGGHSI, strong reduction of activity
I422V
92% of the alpha-aminoadipate reductase activity of wild-type enzyme
I463L
no alpha-aminoadipate reductase activity
I885L G881E
conserved residue in the posttranslational activation domain LGGHSI, less than 50% of wild-type activity
I987V
92% of the alpha-aminoadipate reductase activity of wild-type enzyme
K424R
26% of the alpha-aminoadipate reductase activity of wild-type enzyme
K424T
3% of the alpha-aminoadipate reductase activity of wild-type enzyme
K451Q
58% of the alpha-aminoadipate reductase activity of wild-type enzyme
K451R
no alpha-aminoadipate reductase activity
K535Q
94% of the alpha-aminoadipate reductase activity of wild-type enzyme
L446I
71% of the alpha-aminoadipate reductase activity of wild-type enzyme
L471V
89% of the alpha-aminoadipate reductase activity of wild-type enzyme
L983V
31% of the alpha-aminoadipate reductase activity of wild-type enzyme
M440L
99% of the alpha-aminoadipate reductase activity of wild-type enzyme
P423V
51% of the alpha-aminoadipate reductase activity of wild-type enzyme
P462A
2% of the alpha-aminoadipate reductase activity of wild-type enzyme
P462S
no alpha-aminoadipate reductase activity
Q464E
17% of the alpha-aminoadipate reductase activity of wild-type enzyme
Q511E
31% of the alpha-aminoadipate reductase activity of wild-type enzyme
Q511L
129% of the alpha-aminoadipate reductase activity of wild-type enzyme
R465K
2% of the alpha-aminoadipate reductase activity of wild-type enzyme
R465S
no alpha-aminoadipate reductase activity
S417A
10% of the alpha-aminoadipate reductase activity of wild-type enzyme
S417T
82% of the alpha-aminoadipate reductase activity of wild-type enzyme
S419A
16% of the alpha-aminoadipate reductase activity of wild-type enzyme
S419T
no alpha-aminoadipate reductase activity
S456T
59% of the alpha-aminoadipate reductase activity of wild-type enzyme
S884A
conserved residue in the posttranslational activation domain LGGHSI, loss of activity
S884F
conserved residue in the posttranslational activation domain LGGHSI, loss of activity
S985A
85% of the alpha-aminoadipate reductase activity of wild-type enzyme
T416A
no alpha-aminoadipate reductase activity
T416S
35% of the alpha-aminoadipate reductase activity of wild-type enzyme
T469S
80% of the alpha-aminoadipate reductase activity of wild-type enzyme
T506A
49% of the alpha-aminoadipate reductase activity of wild-type enzyme
T506S
no alpha-aminoadipate reductase activity
T534A
103% of the alpha-aminoadipate reductase activity of wild-type enzyme
T977S
70% of the alpha-aminoadipate reductase activity of wild-type enzyme
T980S
28% of the alpha-aminoadipate reductase activity of wild-type enzyme
V426L
64% of the alpha-aminoadipate reductase activity of wild-type enzyme
V529I
117% of the alpha-aminoadipate reductase activity of wild-type enzyme
G910A
mutation in the activation domain (IGGHSI), no activity
S913A
mutation in the activation domain (IGGHSI), no activity
S913T
mutation in the activation domain (IGGHSI), no activity
additional information