1.2.1.87: propanal dehydrogenase (CoA-propanoylating)

This is an abbreviated version!
For detailed information about propanal dehydrogenase (CoA-propanoylating), go to the full flat file.

Reaction

propanal
+
CoA
+
NAD+
=
propanoyl-CoA
+
NADH
+
H+

Synonyms

BphJ, CoA-acylating aldehyde dehydrogenase, coenzyme A-acylating aldehyde dehydrogenase, More, PduP, TTHB247

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.87 propanal dehydrogenase (CoA-propanoylating)

Systematic Name

Systematic Name on EC 1.2.1.87 - propanal dehydrogenase (CoA-propanoylating)

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SYSTEMATIC NAME
IUBMB Comments
propanal:NAD+ oxidoreductase (CoA-propanoylating)
The enzyme forms a bifunctional complex with EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase, with a tight channel connecting the two subunits [1,2,3]. Also acts, more slowly, on glycolaldehyde and butanal. In Pseudomonas species the enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). NADP+ can replace NAD+ with a much slower rate [3].