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1.2.1.84: alcohol-forming fatty acyl-CoA reductase

This is an abbreviated version!
For detailed information about alcohol-forming fatty acyl-CoA reductase, go to the full flat file.

Word Map on EC 1.2.1.84

Reaction

a long-chain acyl-CoA
+ 2 NADPH + 2 H+ =
a long-chain alcohol
+ 2 NADP+ +
CoA

Synonyms

alcohol-forming FAR, alcohol-forming fatty acyl-CoA reductase, CER4, CG1443, FACR, FAR, FAR1, FAR10, FAR11, FAR12, FAR13, FAR14, FAR15, FAR16, FAR17, FAR2, FAR3, FAR4, FAR5, FAR6, FAR7, FAR8, FAR9, fatty acyl coenzyme A reductase, fatty acyl-CoA reductase, fatty acyl-CoA reductase 1, fatty acyl-CoA reductase 3, fatty acyl-CoA:NADPH oxidoreductase (long chain alcohol forming), fatty acyl-Coenzyme A reductase, FcrA, intestinal acyl-CoA reductase, male sterility C-terminal domain, male sterility domain-containing protein 1, Maqu_2220, Maqu_2507, Ms25, peroxisomal fatty acyl-CoA reductase 1, PsFAR I, PsFAR II, RS30405, wat, Waterproof

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.84 alcohol-forming fatty acyl-CoA reductase

Reference

Reference on EC 1.2.1.84 - alcohol-forming fatty acyl-CoA reductase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Metz, J.G.; Pollard, M.R.; Anderson, L.; Hayes, T.R.; Lassner, M.W.
Purification of a jojoba embryo fatty acyl-coenzyme A reductase and expression of its cDNA in high erucic acid rapeseed
Plant Physiol.
122
635-644
2000
Simmondsia chinensis (Q9XGY7), Simmondsia chinensis
Manually annotated by BRENDA team
Cheng, J.B.; Russell, D.W.
Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions
J. Biol. Chem.
279
37789-37797
2004
Mus musculus (Q7TNT2), Mus musculus (Q922J9), Homo sapiens (Q8WVX9)
Manually annotated by BRENDA team
Burdett, K.; Larkins, L.K.; Das, A.K.; Hajra, A.K.
Peroxisomal localization of acyl-coenzyme A reductase (long chain alcohol forming) in guinea pig intestine mucosal cells
J. Biol. Chem.
266
12201-12206
1991
Cavia porcellus
Manually annotated by BRENDA team
Rowland, O.; Zheng, H.; Hepworth, S.; Lam, P.; Jetter, R.; Kunst, L.
CER4 encodes an alcohol-forming fatty acyl-coenzyme A reductase involved in cuticular wax production in Arabidopsis
Plant Physiol.
142
866-877
2006
Arabidopsis thaliana (Q93ZB9)
Manually annotated by BRENDA team
Domergue, F.; Vishwanath, S.; Joubes, J.; Ono, J.; Lee, J.; Bourdon, M.; Alhattab, R.; Lowe, C.; Pascal, S.; Lessire, R.; Rowland, O.
Three Arabidopsis fatty acyl-coenzyme a reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition
Plant Physiol.
153
1539-1554
2010
Arabidopsis thaliana (Q0WRB0), Arabidopsis thaliana (Q39152), Arabidopsis thaliana (Q9LXN3)
Manually annotated by BRENDA team
Wang, Y.; Wang, M.; Sun, Y.; Wang, Y.; Li, T.; Chai, G.; Jiang, W.; Shan, L.; Li, C.; Xiao, E.; Wang, Z.
FAR5, a fatty acyl-coenzyme A reductase, is involved in primary alcohol biosynthesis of the leaf blade cuticular wax in wheat (Triticum aestivum L.)
J. Exp. Bot.
66
1165-1178
2015
Triticum aestivum (Q8L4V2), Triticum aestivum, Triticum aestivum cv Xinong 2718 (Q8L4V2)
Manually annotated by BRENDA team
Wang, Y.; Wang, M.; Sun, Y.; Hegebarth, D.; Li, T.; Jetter, R.; Wang, Z.
Molecular characterization of TaFAR1 involved in primary alcohol biosynthesis of cuticular wax in hexaploid wheat
Plant Cell Physiol.
56
1944-1961
2015
Triticum aestivum (A0A0A0R526)
Manually annotated by BRENDA team
Miklaszewska, M.; Banas, A.
Biochemical characterization and substrate specificity of jojoba fatty acyl-CoA reductase and jojoba wax synthase
Plant Sci.
249
84-92
2016
Simmondsia chinensis (Q9XGY7)
Manually annotated by BRENDA team
Honsho, M.; Abe, Y.; Fujiki, Y.
Plasmalogen biosynthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membranes
Sci. Rep.
7
43936
2017
Homo sapiens (Q8WVX9)
Manually annotated by BRENDA team
Liu, A.; Tan, X.; Yao, L.; Lu, X.
Fatty alcohol production in engineered E. coli expressing Marinobacter fatty acyl-CoA reductases
Appl. Microbiol. Biotechnol.
97
7061-7071
2013
Marinobacter nauticus (A1U2T0), Marinobacter nauticus (A1U3L3)
Manually annotated by BRENDA team
Jaspers, M.H.; Pflanz, R.; Riedel, D.; Kawelke, S.; Feussner, I.; Schuh, R.
The fatty acyl-CoA reductase Waterproof mediates airway clearance in Drosophila
Dev. Biol.
385
23-31
2014
Drosophila melanogaster (Q8MS59)
Manually annotated by BRENDA team
Honsho, M.; Asaoku, S.; Fukumoto, K.; Fujiki, Y.
Topogenesis and homeostasis of fatty acyl-CoA reductase 1
J. Biol. Chem.
288
34588-34598
2013
Homo sapiens (Q8WVX9)
Manually annotated by BRENDA team
Li, X.; Zheng, T.; Zheng, X.; Han, N.; Chen, X.; Zhang, D.
Molecular characterization of two fatty acyl-CoA reductase genes from Phenacoccus solenopsis (Hemiptera Pseudococcidae)
J. Insect Sci.
16
1-7
2016
Phenacoccus solenopsis (A0A193CHN5), Phenacoccus solenopsis (A0A193CHN6), Phenacoccus solenopsis
Manually annotated by BRENDA team
Miklaszewska, M.; Banas, A.
Biochemical characterization and substrate specificity of jojoba fatty acyl-CoA reductase and jojoba wax synthase
Plant Sci.
249
84-92
2016
Simmondsia chinensis (Q9XGY7)
Manually annotated by BRENDA team
Lanfranconi, M.; Alvarez, H.
Rewiring neutral lipids production for the de novo synthesis of wax esters in Rhodococcus opacus PD630
J. Biotechnol.
260
67-73
2017
Marinobacter nauticus (A1U2T0)
Manually annotated by BRENDA team
Round, J.; Roccor, R.; Li, S.N.; Eltis, L.D.
A fatty acyl coenzyme A reductase promotes wax ester accumulation in Rhodococcus jostii RHA1
Appl. Environ. Microbiol.
83
e00902-17
2017
Rhodococcus jostii
Manually annotated by BRENDA team
Hu, Y.H.; Chen, X.M.; Yang, P.; Ding, W.F.
Characterization and functional assay of a fatty acyl-CoA reductase gene in the scale insect, Ericerus pela Chavannes (Hemiptera Coccoidae)
Arch. Insect Biochem. Physiol.
97
e21445
2018
Ericerus pela
Manually annotated by BRENDA team
Chai, G.; Li, C.; Xu, F.; Li, Y.; Shi, X.; Wang, Y.; Wang, Z.
Three endoplasmic reticulum-associated fatty acyl-coenzyme A reductases were involved in the production of primary alcohols in hexaploid wheat (Triticum aestivum L.)
BMC Plant Biol.
18
41
2018
Triticum aestivum (A0A345D1M5), Triticum aestivum (A0A345YTX7), Triticum aestivum (A0A345YTX8)
Manually annotated by BRENDA team
Foo, J.L.; Rasouliha, B.H.; Susanto, A.V.; Leong, S.S.J.; Chang, M.W.
Engineering an alcohol-forming fatty acyl-CoA reductase for aldehyde and hydrocarbon biosynthesis in Saccharomyces cerevisiae
Front. Bioeng. Biotechnol.
8
585935
2020
Marinobacter nauticus
Manually annotated by BRENDA team
Hambalko, J.; Gajdos, P.; Nicaud, J.M.; Ledesma-Amaro, R.; Tupec, M.; Pichova, I.; Certik, M.
Production of long chain fatty alcohols found in bumblebee pheromones by Yarrowia lipolytica
Front. Bioeng. Biotechnol.
8
593419
2020
Bombus lucorum, Bombus lapidarius
Manually annotated by BRENDA team
Wang, M.; Wu, H.; Xu, J.; Li, C.; Wang, Y.; Wang, Z.
Five fatty acyl-coenzyme A reductases are involved in the biosynthesis of primary alcohols in Aegilops tauschii leaves
Front. Plant Sci.
8
1012
2017
Aegilops tauschii, Aegilops tauschii (A0A0A7NWR9), Aegilops tauschii (A0A0A7NZT1), Aegilops tauschii (A0A140CQH8)
Manually annotated by BRENDA team
Dou, X.; Zhang, A.; Jurenka, R.
Functional identification of fatty acyl reductases in female pheromone gland and tarsi of the corn earworm, Helicoverpa zea
Insect Biochem. Mol. Biol.
116
103260
2020
Helicoverpa zea (A0A5Q0TZK6)
Manually annotated by BRENDA team
Exner, T.; Romero-Brey, I.; Yifrach, E.; Rivera-Monroy, J.; Schrul, B.; Zouboulis, C.C.; Stremmel, W.; Honsho, M.; Bartenschlager, R.; Zalckvar, E.; Poppelreuther, M.; Fuellekrug, J.
An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1
J. Cell Sci.
132
jcs223016
2019
Homo sapiens (Q8WVX9), Homo sapiens
Manually annotated by BRENDA team
Zhang, S.; Wu, S.; Niu, C.; Liu, D.; Yan, T.; Tian, Y.; Liu, S.; Xie, K.; Li, Z.; Wang, Y.; Zhao, W.; Dong, Z.; Zhu, T.; Hou, Q.; Ma, B.; An, X.; Li, J.; Wan, X.
ZmMs25 encoding a plastid-localized fatty acyl reductase is critical for anther and pollen development in maize
J. Exp. Bot.
72
4298-4318
2021
Zea mays
Manually annotated by BRENDA team
McNeil, B.A.; Stuart, D.T.
Optimization of C16 and C18 fatty alcohol production by an engineered strain of Lipomyces starkeyi
J. Ind. Microbiol. Biotechnol.
45
1-14
2018
Mus musculus
Manually annotated by BRENDA team
Li, D.T.; Dai, Y.T.; Chen, X.; Wang, X.Q.; Li, Z.D.; Moussian, B.; Zhang, C.X.
Ten fatty acyl-CoA reductase family genes were essential for the survival of the destructive rice pest, Nilaparvata lugens
Pest Manag. Sci.
76
2304-2315
2020
Nilaparvata lugens
Manually annotated by BRENDA team
Wang, Y.; Sun, Y.; You, Q.; Luo, W.; Wang, C.; Zhao, S.; Chai, G.; Li, T.; Shi, X.; Li, C.; Jetter, R.; Wang, Z.
Three fatty acyl-coenzyme A reductases, BdFAR1, BdFAR2 and BdFAR3, are involved in cuticular wax primary alcohol biosynthesis in Brachypodium distachyon
Plant Cell Physiol.
59
527-543
2018
Brachypodium distachyon, Brachypodium distachyon (I1ISS8), Brachypodium distachyon (I1IT05)
Manually annotated by BRENDA team
Wang, Y.; Xu, J.; He, Z.; Hu, N.; Luo, W.; Liu, X.; Shi, X.; Liu, T.; Jiang, Q.; An, P.; Liu, L.; Sun, Y.; Jetter, R.; Li, C.; Wang, Z.
BdFAR4, a root-specific fatty acyl-coenzyme A reductase, is involved in fatty alcohol synthesis of root suberin polyester in Brachypodium distachyon
Plant J.
106
1468-1483
2021
Brachypodium distachyon
Manually annotated by BRENDA team