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1.2.1.84: alcohol-forming fatty acyl-CoA reductase

This is an abbreviated version!
For detailed information about alcohol-forming fatty acyl-CoA reductase, go to the full flat file.

Word Map on EC 1.2.1.84

Reaction

a long-chain acyl-CoA
+ 2 NADPH + 2 H+ =
a long-chain alcohol
 + 2 NADP+ +
CoA

Synonyms

alcohol-forming FAR, alcohol-forming fatty acyl-CoA reductase, CER4, CG1443, FACR, FAR, FAR1, FAR10, FAR11, FAR12, FAR13, FAR14, FAR15, FAR16, FAR17, FAR2, FAR3, FAR4, FAR5, FAR6, FAR7, FAR8, FAR9, fatty acyl coenzyme A reductase, fatty acyl-CoA reductase, fatty acyl-CoA reductase 1, fatty acyl-CoA reductase 3, fatty acyl-CoA:NADPH oxidoreductase (long chain alcohol forming), fatty acyl-Coenzyme A reductase, FcrA, intestinal acyl-CoA reductase, male sterility C-terminal domain, male sterility domain-containing protein 1, Maqu_2220, Maqu_2507, Ms25, peroxisomal fatty acyl-CoA reductase 1, PsFAR I, PsFAR II, RS30405, wat, Waterproof

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.84 alcohol-forming fatty acyl-CoA reductase

Natural Substrates Products

Natural Substrates Products on EC 1.2.1.84 - alcohol-forming fatty acyl-CoA reductase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + CoA
show the reaction diagram
Marinobacter nauticus
-
-
-
?
a long-chain acyl-CoA + 2 NADPH + 2 H+
a long-chain alcohol + 2 NADP+ + coenzyme A
show the reaction diagram
docosanoyl-CoA + 2 NADPH + 2 H+
1-docosanol + CoA + 2 NADP+
show the reaction diagram
-
-
-
-
?
eicosanoyl-CoA + 2 NADPH + 2 H+
1-eicosanol + CoA + 2 NADP+
show the reaction diagram
-
-
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
hexacosanoyl alcohol + 2 NADP+ + coenzyme A
show the reaction diagram
-
-
-
?
hexacosanoyl-CoA + 2 NADPH + 2 H+
hexacosanoyl alcohol + CoA + 2 NADP+
show the reaction diagram
-
-
-
-
?
tetracosanoyl-CoA + 2 NADPH + 2 H+
tetracosanoyl alcohol + 2 NADP+ + coenzyme A
show the reaction diagram
-
-
-
?
additional information
?
-
Waterproof is a Drosophila FAR with a preference for very long chain, saturated fatty acids of 24 and 26 carbons. In yeast cultures expressing Waterproof, tetracosanoyl-alcohol (24:0-OH) and hexacosanoyl-alcohol (26:0-OH) are identified by GC/MS analysis, unsaturated alcohols or alcohols of shorter chain-lengths are either absent or below the detection limit. Neither of these fatty alcohols is detected in the vector control yeast culture or the wat gene containing culture grown under non-inducing conditions
-
-
?