1.2.1.80: long-chain acyl-[acyl-carrier-protein] reductase

This is an abbreviated version!
For detailed information about long-chain acyl-[acyl-carrier-protein] reductase, go to the full flat file.

Word Map on EC 1.2.1.80

Reaction

a long-chain aldehyde
+
an [acyl-carrier protein]
+
NAD(P)+
=
a long-chain acyl-[acyl-carrier protein]
+
NAD(P)H
+
H+

Synonyms

AAR, acyl-ACP reductase, acyl-acyl carrier protein reductase, AtFAR6, CpFAS1 acyl reductase, CpFAS1-R, fatty aldehyde-generating acyl-ACP reductase, Npun_R1710

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.80 long-chain acyl-[acyl-carrier-protein] reductase

Substrates Products

Substrates Products on EC 1.2.1.80 - long-chain acyl-[acyl-carrier-protein] reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
fatty acyl-CoA + NAD(P)H + H+
fatty aldehyde + CoA + NAD(P)+
show the reaction diagram
-
CpFAS1-R can only utilize very long chain fatty acyl-CoAs as substrates, with activity on C26 > C24 > C22 > C20, but no activity on C18 and C16 or fewer carbons
since aldehydes are toxic to cells it is very likely that the fatty aldehyde is immediately transformed into the corresponding alcohol by the enzyme complex
-
?
fatty acyl-[acyl carrier protein] + NAD(P)H + H+
fatty aldehyde + acyl carrier protein + NAD(P)+
show the reaction diagram
-
kinetically preferred and likely the in vivo substrate
-
-
?
fatty acyl-[acyl-carrier protein] + NAD(P)H + H+
fatty aldehyde + acyl-carrier protein + NAD(P)+
show the reaction diagram
-
-
-
-
?
hexacosanoyl-CoA + NAD(P)H + H+
hexacosanal + CoA + NAD(P)+
show the reaction diagram
-
-
-
-
?
hexadecanoyl-[acyl-carrier protein] + NAD(P)H + H+
hexadecanal + acyl-carrier protein + NAD(P)+
show the reaction diagram
oleoyl-[acyl carrier protein] + NAD(P)H + H+
oleic aldehyde + acyl carrier protein + NAD(P)+
show the reaction diagram
-
-
-
-
?
stearoyl-[acyl-carrier protein] + NAD(P)H + H+
stearylaldehyde + an [acyl-carrier protein] + NAD(P)+
show the reaction diagram
additional information
?
-