1.2.1.80: long-chain acyl-[acyl-carrier-protein] reductase

This is an abbreviated version!
For detailed information about long-chain acyl-[acyl-carrier-protein] reductase, go to the full flat file.

Word Map on EC 1.2.1.80

Reaction

a long-chain aldehyde
+
an [acyl-carrier protein]
+
NAD(P)+
=
a long-chain acyl-[acyl-carrier protein]
+
NAD(P)H
+
H+

Synonyms

AAR, acyl-ACP reductase, acyl-acyl carrier protein reductase, AtFAR6, CpFAS1 acyl reductase, CpFAS1-R, fatty aldehyde-generating acyl-ACP reductase, Npun_R1710

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.80 long-chain acyl-[acyl-carrier-protein] reductase

Cloned

Cloned on EC 1.2.1.80 - long-chain acyl-[acyl-carrier-protein] reductase

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CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
AtFAR6 full length version and a truncated version, mAtFAR6, which lacks the chloroplast transit peptide sequence expressed in Escherichia coli, both enzymes fused at the C-terminus to a His Tag containing maltose binding protein; AtFAR6 full length version and a truncated version, mAtFAR6, which lacks the chloroplast transit peptide sequence subcloned into the pYES-DEST52 plasmid downstream of the GAL1 promoter and transformed into Saccharomyces cerevisiae W303-1A strain
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expession in Escherichia coli
expression of strain PCC7942 orf1593 and orf1594, the latter encoding an aldehde decarbonylase, both separately and together in Escherichia coli. Extracts of recombinant PCC7942_orf1594-expressing cells contain substantial quantities of evenchain fatty aldehydes and fatty alcohols, whereas coexpression of both PCC7942_orf1593 and orf1594 results in the production of odd chain alkanes and alkenes, as well as even-chain fatty aldehydes and fatty alcohols. Orf1593 and orf1594 appear to be part of a larger operon that contains a gene encoding a subunit of the acetyl-CoA carboxylase, accA, which is essential for growth
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in a Rosetta bacterial strain serving as an expression host for the maltose-binding protein-CpFAS1-R fusion protein
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