1.2.1.8: betaine-aldehyde dehydrogenase

This is an abbreviated version!
For detailed information about betaine-aldehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

AcBADH, ALD10, aldehyde dehydrogenase, ALDH10, ALDH10A8, ALDH10A9, AMADH, AMADH1, aminoaldehyde dehydrogenase, BADH, BADH1, BADH2, badh2-E2, badh2-E7, betaine aldehyde dehydrogenase, betaine aldehyde dehydrogenase 1, betaine aldehyde dehydrogenase 1, chloroplastic, betaine aldehyde dehydrogenase 2, betaine aldehyde dehydrogenase, chloroplastic, betaine aldehyde oxidase, betaine aldehyde: NAD(P)+ oxidoreductase, betaine aldehyde: NAD+ oxidoreductase, betaine aldehyde:NAD(P)+ oxidoreductase, betaine aldehyde:NAD+ oxidoreductase, betaine-aldehyde dehydrogenase, BetB, dehydrogenase, betaine aldehyde, JcBD1, LcBADH, More, OsALDH10-1, OsALDH10-2, OsBADH1, OsBADH2, PaBADH, PaBADH2, pkBADH, PND BADH2, SACOL2628, YdcW, ZBD1, Zoysia betaine aldehyde dehydrogenase 1

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.8 betaine-aldehyde dehydrogenase

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Results	in table
20	Activating Compound
13838	AA Sequence
26	Application
1	CAS Registry Number
72	Cloned(Commentary)
134	Cofactor
7	Crystallization (Commentary)
9	Disease/ Diagnostics
12	Expression
59	General Information
7	General Stability
131	Inhibitors
30	kcat/KM [mM/s]
28	Ki Value [mM]
184	KM Value [mM]
44	Localization
24	Metals/Ions
50	Molecular Weight [Da]
121	Natural Substrates/ Products (Substrates)
189	Organism
2	Oxidation Stability
13	Pathway
281	PDB ID
28	pH Optimum
5	pH Range
6	pH Stability
7	pI Value
9	Posttranslational Modification
53	Protein Variants
43	Purification (Commentary)
13	Reaction
29	Reaction Type
163	Reference
3	Renatured (Commentary)
106	Source Tissue
48	Specific Activity [micromol/min/mg]
6	Storage Stability
297	Substrates and Products (Substrate)
41	Subunits
285	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
3	Temperature Range [°C]
16	Temperature Stability [°C]
35	Turnover Number [1/s]

Disease

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Disease on EC 1.2.1.8 - betaine-aldehyde dehydrogenase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Infections

Disulfiram irreversibly aggregates betaine aldehyde dehydrogenase--a potential target for antimicrobial agents against Pseudomonas aeruginosa.

16426571

Infections

The disulfiram metabolites S-methyl-N,N-diethyldithiocarbamoyl sulfoxide and S-methyl-N,N-diethylthiocarbamoyl sulfone irreversibly inactivate betaine aldehyde dehydrogenase from Pseudomonas aeruginosa, both in vitro and in situ, and arrest bacterial growth.

20933050

Starvation

Upregulation of stress response genes and ABC transporters in anaerobic stationary-phase Mycobacterium smegmatis.

10628850

Tuberculosis

Upregulation of stress response genes and ABC transporters in anaerobic stationary-phase Mycobacterium smegmatis.

10628850

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