1.2.1.79: succinate-semialdehyde dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

AbSSADH, ALDH21, all3556, ApSSADH, gabD, GabD1, NADP+-dependent SSADH, NADP+-dependent succinic semialdehyde dehydrogenase, NADP-dependent succinic semialdehyde dehydrogenase, PpSSALDH, slr0370, Sp2771, SpSSADH, SSADH, SSADH-II, SSALDH, SSO1842, succinic semialdehy de dehydrogenase, succinic semialdehyde dehydrogenase, SYNPCC7002_A2771, SySSADH

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)

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Results	in table
9	Activating Compound
4196	AA Sequence
1	Application
17	Cloned(Commentary)
34	Cofactor
11	Crystallization (Commentary)
5	Expression
26	General Information
1	IC50 Value
28	Inhibitors
33	kcat/KM [mM/s]
3	Ki Value [mM]
53	KM Value [mM]
2	Localization
10	Metals/Ions
11	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
34	Organism
3	Oxidation Stability
11	Pathway
4	PDB ID
11	pH Optimum
4	pH Range
1	pH Stability
1	Posttranslational Modification
35	Protein Variants
9	Purification (Commentary)
4	Reaction
31	Reference
6	Specific Activity [micromol/min/mg]
3	Storage Stability
64	Substrates and Products (Substrate)
17	Subunits
58	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
4	Temperature Stability [°C]
29	Turnover Number [1/s]

Oxidation Stability

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Oxidation Stability on EC 1.2.1.79 - succinate-semialdehyde dehydrogenase (NADP+)

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OXIDATION STABILITY

ORGANISM

UNIPROT

LITERATURE

GabD1 is naturally resistant to oxidation by H2O2

Mycobacterium tuberculosis

P9WNX9

724115

SySSADH is an oxidation-sensitive enzyme and the formation of the NADP-cysteine adduct is a kinetically preferred event that protects the catalytic Cys-262 from H2O2-dependent oxidative stress

Synechococcus sp.

B1XMM6

725523

SySSADH is an oxidation-sensitive enzyme, the formation of the NADP-cysteine adduct is a kinetically preferred event that protects the catalytic cysteine from H2O2-dependent oxidative stress. Over 70% of the original SySSADH activity is maintained with 0.005-0.25 mM H2O2 with a further drop of activity to 40% at 1 m H2O2. Comparable or even higher enzyme activity is observed when SySSADH is preincubated for 10 min with 2.5 mM NADP+ followed by H2O2 treatment for 60 min

Synechococcus sp.

B1XMM6

742844