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1.2.1.77: 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+), go to the full flat file.

Reaction

3,4-didehydroadipyl-CoA semialdehyde
+
NADP+
+
H2O
=
3,4-didehydroadipyl-CoA
+
NADPH
+
H+

Synonyms

3,4-dehydroadipyl-CoA semialdehyde dehydrogenase, ALDH, ALDHC, BoxD, NADP+-dependent aldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.77 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)

Cofactor

Cofactor on EC 1.2.1.77 - 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)

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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
the enzyme is more active in the presence of NADP+ relative to NAD+. Crystallographic data show that cofactor selectivity is governed by a complex network of hydrogen bonds between the oxygen atoms of the 2'-phosphoryl moiety of NADP+ and a threonine/lysine pair on the enzyme
NADP+