1.2.1.77: 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
3,4-dehydroadipyl-CoA semialdehyde dehydrogenase, ALDH, ALDHC, BoxD, NADP+-dependent aldehyde dehydrogenase
ECTree
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Cofactor
Cofactor on EC 1.2.1.77 - 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)
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NAD+
the enzyme is more active in the presence of NADP+ relative to NAD+. Crystallographic data show that cofactor selectivity is governed by a complex network of hydrogen bonds between the oxygen atoms of the 2'-phosphoryl moiety of NADP+ and a threonine/lysine pair on the enzyme
NADP+
-
no activity (below 2%) with NAD+. The molar ratio of mol of converted substrate per mol of NADPH formed is estimated to be 1
NADP+
the enzyme is more active in the presence of NADP+ relative to NAD+. Crystallographic data show that cofactor selectivity is governed by a complex network of hydrogen bonds between the oxygen atoms of the 2'-phosphoryl moiety of NADP+ and a threonine/lysine pair on the enzyme