1.2.1.71: succinylglutamate-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about succinylglutamate-semialdehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

aruD, AstD, N-succinylglutamate 5-semialdehyde dehydrogenase, SGSD, succinic semialdehyde dehydrogenase, succinylglutamic semialdehyde dehydrogenase

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.71 succinylglutamate-semialdehyde dehydrogenase

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6249	AA Sequence
1	CAS Registry Number
1	Cofactor
6	Natural Substrates/ Products (Substrates)
7	Organism
5	Pathway
8	PDB ID
1	Reaction
3	Reaction Type
7	Reference
11	Substrates and Products (Substrate)
7	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.2.1.71 - succinylglutamate-semialdehyde dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase

This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6].