1.2.1.70: glutamyl-tRNA reductase
This is an abbreviated version!
For detailed information about glutamyl-tRNA reductase, go to the full flat file.
Word Map on EC 1.2.1.70
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1.2.1.70
-
tetrapyrrole
-
chlorophyl
-
ala
-
5-aminolevulinic
-
heme
-
glutamate-1-semialdehyde
-
protochlorophyllide
-
delta-aminolevulinic
-
1-semialdehyde
-
de-etiolation
-
chelatase
-
mg-protoporphyrin
-
glu-trna
-
trna-dependent
-
kandleri
-
pchlide
-
gun4
-
glu-trnaglu
-
trna-bound
-
2,1-aminomutase
-
biotechnology
-
synthesis
- 1.2.1.70
- tetrapyrrole
-
chlorophyl
- ala
-
5-aminolevulinic
- heme
- glutamate-1-semialdehyde
- protochlorophyllide
-
delta-aminolevulinic
- 1-semialdehyde
-
de-etiolation
- chelatase
- mg-protoporphyrin
- glu-trna
-
trna-dependent
- kandleri
-
pchlide
- gun4
- glu-trnaglu
-
trna-bound
-
2,1-aminomutase
- biotechnology
- synthesis
Reaction
Synonyms
AtHEMA1, EC 2.7.2.13, GluRS, glutamate tRNA reductase, glutamate-specific tRNA reductase, glutamyl transfer RNA reductase, glutamyl-tRNA reductase, GluTR, GluTR1, GTR, GtrR, hemA, HEMA1, HEMA2, reductase, glutamyl-transfer ribonucleate, ZjGluTR
ECTree
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Reference on EC 1.2.1.70 - glutamyl-tRNA reductase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Willows, R.D.; Kannangara, C.G.; Pontoppidan, B.
Nucleotides of tRNA(Glu) involved in recognition by barley chloroplast glutamyl-tRNA synthetase and glutamyl-tRNA reductase
Biochim. Biophys. Acta
1263
228-234
1995
Hordeum vulgare
Loida, P.J.; Thompson, R.L.; Walker, D.M.; CaJacob, C.A.
Novel inhibitors of glutamyl-tRNA(Glu) reductase identified through cell-based screening of the heme/chlorophyll biosynthetic pathway
Arch. Biochem. Biophys.
372
230-237
1999
Arabidopsis thaliana
Moser, J.; Schubert, W.D.; Heinz, D.W.; Jahn, D.
Structure and function of glutamyl-tRNA reductase involved in 5-aminolaevulinic acid formation
Biochem. Soc. Trans.
30
579-584
2002
Methanopyrus kandleri
Pontoppida, B.; Kannangara, C.G.
Purification and partial characterization of barley glutamyl-tRNAGlu reductase,the enzyme that directs glutamate to chlorophyll biosynthesis
Eur. J. Biochem.
225
529-537
1994
Hordeum vulgare
Jahn, D.
Complex formation between glutamyl-tRNA synthetase and glutamyl-tRNA reductase during the tRNA-dependent synthesis of 5-aminolevulinic acid in Chlamydomonas reinhardtii
FEBS Lett.
314
77-80
1992
Chlamydomonas reinhardtii
Chen, M.W.; Jahn, D.; O'Neill, G.P.; Soll, D.
Purification of the glutamyl-tRNA reductase from Chlamydomonas reinhardtii involved in delta-aminolevulinic acid formation during chlorophyll biosynthesis
J. Biol. Chem.
265
4058-4063
1990
Chlamydomonas reinhardtii
Rieble, S.; Beale, S.I.
Purification of glutamyl-tRNA reductase from Synechocystis sp. PCC 6803
J. Biol. Chem.
266
9740-9745
1991
Synechocystis sp.
Moser, J.; Lorenz, S.; Hubschwerlen, C.; Rompf, A.; Jahn, D.
Methanopyrus kandleri glutamyl-tRNA reductase
J. Biol. Chem.
274
30679-30685
1999
Methanopyrus kandleri (Q9UXR8), Methanopyrus kandleri
Schauer, S.; Chaturvedi, S.; Randau, L.; Moser, J.; Kitabatake, M.; Lorenz, S.; Verkamp, E.; Schubert, W.D.; Nakayashiki, T.; Murai, M.; Wall, K.; Thomann, H.U.; Heinz, D.W.; Inokuchi, H.; Soll, D.; Jahn, D.
Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate
J. Biol. Chem.
277
48657-48663
2002
Escherichia coli
Randau, L.; Schauer, S.; Ambrogelly, A.; Salazar, J.C.; Moser, J.; Sekine, S.; Yokoyama, S.; Soll, D.; Jahn, D.
tRNA recognition by glutamyl-tRNA reductase
J. Biol. Chem.
279
34931-34937
2004
Escherichia coli
Schubert, W.D.; Moser, J.; Schauer, S.; Heinz, D.W.; Jahn, D.
Structure and function of glutamyl-tRNA reductase, the first enzyme of tetrapyrrole biosynthesis in plants and prokaryotes
Photosynth. Res.
74
205-215 (c)
2002
Methanopyrus kandleri
Vothknecht, U.C.; Kannangara, C.G.; von Wettstein, D.
Barley glutamyl tRNAGlu reductase: mutations affecting haem inhibition and enzyme activity
Phytochemistry
47
513-519
1998
Hordeum vulgare
Masuda, T.; Ohta, H.; Shioi, Y.; Tsuji, H.; Takamiya, K.i.
Stimulation of glutamyl-tRNA reductase activity by benzyladenine in greening cucumber cotyledons
Plant Cell Physiol.
36
1237-1243
1995
Cucumis sativus
-
Masuda, T.; Ohta, H.; Shioi, Y.; Takamiya, K.i.
Light regulation of 5-aminolevulinic acid-synthesis system in Cucumis sativus: light stimulates activity of glutamyl-tRNA reductase during greening
Plant Physiol. Biochem.
34
11-16
1996
Cucumis sativus
-
Vothknecht, U.C.; Kannangara, C.G.; von Wettstein, D.
Expression of catalytically active barley glutamyl tRNAGlu reductase in Escherichia coli as a fusion protein with glutathione S-transferase
Proc. Natl. Acad. Sci. USA
93
9287-9291
1996
Hordeum vulgare (Q42843)
Schauer, S.; Luer, C.; Moser, J.
Large scale production of biologically active Escherichia coli glutamyl-tRNA reductase from inclusion bodies
Protein Expr. Purif.
31
271-275
2003
Escherichia coli
Levican, G.; Katz, A.; Valenzuela, P.; Soell, D.; Orellana, O.
A tRNA(Glu) that uncouples protein and tetrapyrrole biosynthesis
FEBS Lett.
579
6383-6387
2005
Acidithiobacillus ferrooxidans
Srivastava, A.; Beale, S.I.
Glutamyl-tRNA reductase of Chlorobium vibrioforme is a dissociable homodimer that contains one tightly bound heme per subunit
J. Bacteriol.
187
4444-4450
2005
Prosthecochloris vibrioformis (P28462), Prosthecochloris vibrioformis
Petricek, M.; Petrickova, K.; Havlicek, L.; Felsberg, J.
Occurrence of two 5-aminolevulinate biosynthetic pathways in Streptomyces nodosus subsp. asukaensis is linked with the production of asukamycin
J. Bacteriol.
188
5113-5123
2006
Streptomyces coelicolor, Streptomyces nodosus, Streptomyces coelicolor J1501
Nogaj, L.A.; Beale, S.I.
Physical and kinetic interactions between glutamyl-tRNA reductase and glutamate-1-semialdehyde aminotransferase of Chlamydomonas reinhardtii
J. Biol. Chem.
280
24301-24307
2005
Chlamydomonas reinhardtii
Srivastava, A.; Lake, V.; Nogaj, L.A.; Mayer, S.M.; Willows, R.D.; Beale, S.I.
The Chlamydomonas reinhardtii gtr gene encoding the tetrapyrrole biosynthetic enzyme glutamyl-trna reductase: structure of the gene and properties of the expressed enzyme
Plant Mol. Biol.
58
643-658
2005
Chlamydomonas reinhardtii (Q9FPR7), Chlamydomonas reinhardtii, Chlamydomonas reinhardtii CC-124 (Q9FPR7)
Nogaj, L.A.; Srivastava, A.; van Lis, R.; Beale, S.I.
Cellular levels of glutamyl-tRNA reductase and glutamate-1-semialdehyde aminotransferase do not control chlorophyll synthesis in Chlamydomonas reinhardtii
Plant Physiol.
139
389-396
2005
Chlamydomonas reinhardtii
Yaronskaya, E.; Vershilovskaya, I.; Poers, Y.; Alawady, A.E.; Averina, N.; Grimm, B.
Cytokinin effects on tetrapyrrole biosynthesis and photosynthetic activity in barley seedlings
Planta
224
700-709
2006
Hordeum vulgare
Levican, G.; Katz, A.; de Armas, M.; Nunez, H.; Orellana, O.
Regulation of a glutamyl-tRNA synthetase by the heme status
Proc. Natl. Acad. Sci. USA
104
3135-3140
2007
Acidithiobacillus ferrooxidans
Lueer, C.; Schauer, S.; Virus, S.; Schubert, W.D.; Heinz, D.W.; Moser, J.; Jahn, D.
Glutamate recognition and hydride transfer by Escherichia coli glutamyl-tRNA reductase
FEBS J.
274
4609-4614
2007
Escherichia coli (P0A6X1), Escherichia coli
Nagai, S.; Koide, M.; Takahashi, S.; Kikuta, A.; Aono, M.; Sasaki-Sekimoto, Y.; Ohta, H.; Takamiya, K.; Masuda, T.
Induction of isoforms of tetrapyrrole biosynthetic enzymes, AtHEMA2 and AtFC1, under stress conditions and their physiological functions in Arabidopsis
Plant Physiol.
144
1039-1051
2007
Arabidopsis thaliana
Demko, V.; Pavlovic, A.; Hudak, J.
Gabaculine alters plastid development and differentially affects abundance of plastid-encoded DPOR and nuclear-encoded GluTR and FLU-like proteins in spruce cotyledons
J. Plant Physiol.
167
693-700
2010
Picea abies (D3JIR5), Picea abies
Demko, V.; Pavlovic, A.; Valkova, D.; Slovakova, L.; Grimm, B.; Hudak, J.
A novel insight into the regulation of light-independent chlorophyll biosynthesis in Larix decidua and Picea abies seedlings
Planta
230
165-176
2009
Larix decidua, Picea abies
Kang, Z.; Wang, Y.; Gu, P.; Wang, Q.; Qi, Q.
Engineering Escherichia coli for efficient production of 5-aminolevulinic acid from glucose
Metab. Eng.
13
492-498
2011
Salmonella enterica subsp. arizonae
de Armas-Ricard, M.; Levican, G.; Katz, A.; Moser, J.; Jahn, D.; Orellana, O.
Cellular levels of heme affect the activity of dimeric glutamyl-tRNA reductase
Biochem. Biophys. Res. Commun.
405
134-139
2011
Acidithiobacillus ferrooxidans
Schmied, J.; Hedtke, B.; Grimm, B.
Overexpression of HEMA1 encoding glutamyl-tRNA reductase
J. Plant Physiol.
168
1372-1379
2011
Arabidopsis thaliana
Czarnecki, O.; Hedtke, B.; Melzer, M.; Rothbart, M.; Richter, A.; Schroeter, Y.; Pfannschmidt, T.; Grimm, B.
An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts
Plant Cell
23
4476-4491
2011
Arabidopsis thaliana
Liu, Z.; Zhao, J.; Liu, M.
Isolation and bioinformatic analysis of glutamyl-tRNA reductase in Chinese jujube
Acta Hortic.
1116
43-48
2016
Ziziphus jujuba
-
Zhang, J.; Weng, H.; Ding, W.; Kang, Z.
N-terminal engineering of glutamyl-tRNA reductase with positive charge arginine to increase 5-aminolevulinic acid biosynthesis
Bioengineered
8
424-427
2017
Escherichia coli
Kars, G.; Alparslan, U.e.
Heterologous expression of glutamyl-tRNA reductase gene in Rhodobacter sphaeroides O.U.001 to enhance 5-aminolevulinic acid production
Biotechnol. Biotechnol. Equip.
28
1034-1041
2014
Rhodospirillum rubrum, Rhodospirillum rubrum DSM 467
Farah, C.; Levican, G.; Ibba, M.; Orellana, O.
Effect of hydrogen peroxide on the biosynthesis of heme and proteins potential implications for the partitioning of Glu-tRNA(Glu) between these pathways
Int. J. Mol. Sci.
15
23011-23023
2014
Acidithiobacillus ferrooxidans (B7J8J0), Acidithiobacillus ferrooxidans
Zhang, M.; Zhang, F.; Fang, Y.; Chen, X.; Chen, Y.; Zhang, W.; Dai, H.E.; Lin, R.; Liu, L.
The non-canonical tetratricopeptide repeat (TPR) domain of fluorescent (FLU) mediates complex formation with glutamyl-tRNA reductase
J. Biol. Chem.
290
17559-17565
2015
Arabidopsis thaliana (P42804)
Czarnecki, O.; Grimm, B.
New insights in the topology of the biosynthesis of 5-aminolevulinic acid
Plant Signal. Behav.
8
e23124
2013
Arabidopsis thaliana
Zhao, A.; Fang, Y.; Chen, X.; Zhao, S.; Dong, W.; Lin, Y.; Gong, W.; Liu, L.
Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein
Proc. Natl. Acad. Sci. USA
111
6630-6635
2014
Arabidopsis thaliana (P42804), Arabidopsis thaliana
Fang, Y.; Zhao, S.; Zhang, F.; Zhao, A.; Zhang, W.; Zhang, M.; Liu, L.
The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex with FLU and GluTR-binding protein
Sci. Rep.
6
19756
2016
Arabidopsis thaliana (P42804)
Richter, A.S.; Banse, C.; Grimm, B.
The GluTR-binding protein is the heme-binding factor for feedback control of glutamyl-tRNA reductase
eLife
8
e46300
2019
Arabidopsis thaliana
Zeng, Z.; Lin, T.; Zhao, J.; Zheng, T.; Xu, L.; Wang, Y.; Liu, L.; Jiang, L.; Chen, S.; Wan, J.
OsHemA gene, encoding glutamyl-tRNA reductase (GluTR) is essential for chlorophyll biosynthesis in rice (Oryza sativa)
J. Integr. Agric.
19
612-623
2020
Oryza sativa
-
Choby, J.E.; Grunenwald, C.M.; Celis, A.I.; Gerdes, S.Y.; DuBois, J.L.; Skaar, E.P.
Staphylococcus aureus HemX modulates glutamyl-tRNA reductase abundance to regulate heme biosynthesis
mBio
9
e02287-17
2018
Staphylococcus aureus, Staphylococcus aureus Newman
Schmied, J.; Hou, Z.; Hedtke, B.; Grimm, B.
Controlled partitioning of glutamyl-tRNA reductase in stroma- and membrane-associated fractions affects the synthesis of 5-aminolevulinic acid
Plant Cell Physiol.
59
2204-2213
2018
Arabidopsis thaliana
Hou, Z.; Yang, Y.; Hedtke, B.; Grimm, B.
Fluorescence in blue light (FLU) is involved in inactivation and localization of glutamyl-tRNA reductase during light exposure
Plant J.
97
517-529
2019
Arabidopsis thaliana
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