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1.2.1.65: salicylaldehyde dehydrogenase

This is an abbreviated version!
For detailed information about salicylaldehyde dehydrogenase, go to the full flat file.

Wordmap for 1.2.1.65

Word Map on EC 1.2.1.65 Wordmap for 1.2.1.65

Reaction

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Salicylaldehyde
+
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NAD+
+
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H2O
=
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salicylate
+
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NADH
+ 2 H+

Synonyms

NAD+-dependent salicylaldehyde dehydrogenase, NahF, NahV, SAL dehydrogenase, SALD, SALDan, sALDH, salicylaldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                EC 1.2.1.651.2.1.65 salicylaldehyde dehydrogenase

General Information

General Information on EC 1.2.1.65 - salicylaldehyde dehydrogenase

for references in articles please use BRENDA:EC1.2.1.65

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
network and phylogenetic analyses indicated that salicylaldehyde dehydrogenases (SALDs) and the homologues are present in bacteria and fungi, phylogenetic tree, distribution, and evolution of SALD, overview. Key residues in SALDs are analyzed by evolutionary methods and a molecular simulation analysis. The catalytic residue is most highly conserved, followed by the residues binding NAD+ and then the residues binding salicylaldehyde, molecular simulation analysis
malfunction
site-directed mutagenesis of selected residues binding NAD+ and/or SAL affects the enzyme's catalytic efficiency, but does not eliminate catalysis. Cys284 is positioned close to both NAD+ and SAL, implicating it as a potentially important residue
metabolism
physiological function
additional information