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1.2.1.65: salicylaldehyde dehydrogenase

This is an abbreviated version!
For detailed information about salicylaldehyde dehydrogenase, go to the full flat file.

Wordmap for 1.2.1.65

Word Map on EC 1.2.1.65 Wordmap for 1.2.1.65

Reaction

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Salicylaldehyde
+
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NAD+
+
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H2O
=
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salicylate
+
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NADH
+ 2 H+

Synonyms

NAD+-dependent salicylaldehyde dehydrogenase, NahF, NahV, SAL dehydrogenase, SALD, SALDan, sALDH, salicylaldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                EC 1.2.1.651.2.1.65 salicylaldehyde dehydrogenase

Engineering

Engineering on EC 1.2.1.65 - salicylaldehyde dehydrogenase

for references in articles please use BRENDA:EC1.2.1.65

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E175A
site-directed mutagenesis, the apparent Km value of the mutant enzyme to NAD+ is increased by about 2times and the kcat/Km toward the cofactor decreased by 4times. The Km value of the mutant toward salicylaldehyde also increases and the catalytic efficiency decreases by 6times compared to the wild-type enzyme
N149A
site-directed mutagenesis, the catalyic efficiency of the mutant is decreased compared to the wild-type enzyme
V153A
site-directed mutagenesis, the mutation has no significant effect on the kinetic parameters for either NAD+ or salicylaldehyde compared to the wild-type enzyme
additional information