1.2.1.61: 4-hydroxymuconic-semialdehyde dehydrogenase
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For detailed information about 4-hydroxymuconic-semialdehyde dehydrogenase, go to the full flat file.
Reaction
Synonyms
4-HS dehydrogenase, 4-hydroxymuconic semialdehyde dehydrogenase, gamma-hydroxymuconic semialdehyde dehydrogenase, hAPE, HqdC, NAD dependent gamma-hydroxymuconic semialdehyde dehydrogenase, PdcG, pnpE
ECTree
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Subunits
Subunits on EC 1.2.1.61 - 4-hydroxymuconic-semialdehyde dehydrogenase
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additional information
the monomer of PnpE has the typical structural organization betaalphabeta of the ALDH family, with 17 beta-strands and 14 alpha-helices, the secondary structures belong to three domains: a substrate binding domain, a cofactor binding domain, and an oligomerization domain mediating protein dimerization. The substrate binding domain consists of a central six-stranded beta-sheet and six alpha-helices, while the cofactor binding domain contains a nine-stranded beta-sheet and seven alpha-helices, structure, overview