1.2.1.58: phenylglyoxylate dehydrogenase (acylating)

This is an abbreviated version!
For detailed information about phenylglyoxylate dehydrogenase (acylating), go to the full flat file.

Reaction

Synonyms

Dehydrogenase, phenylglyoxylate (CoA-benzoylating), Phenylglyoxal:NAD+ oxidoreductase (CoA benzoylating), Phenylglyoxylate dehydrogenase (CoA benzoylating), Phenylglyoxylate-acceptor oxidoreductase, Phenylglyoxylate:acceptor oxidoreductase

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.58 phenylglyoxylate dehydrogenase (acylating)

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Results	in table
504	AA Sequence
1	CAS Registry Number
2	Cofactor
3	KM Value [mM]
1	Metals/Ions
6	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
2	Organism
3	Pathway
1	pH Optimum
1	Purification (Commentary)
1	Reaction
2	Reaction Type
2	Reference
2	Specific Activity [micromol/min/mg]
3	Storage Stability
12	Substrates and Products (Substrate)
1	Subunits
5	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.2.1.58 - phenylglyoxylate dehydrogenase (acylating)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-oxoisovalerate + NAD+ + CoA-SH

?

Aromatoleum evansii

-

at 15% of the activity relative to phenylglyoxylate

11535

-

-

?

phenylglyoxylate + benzyl viologen + CoA-SH

benzoyl-S-CoA + CO2 + reduced benzyl viologen

2 entries

phenylglyoxylate + FAD + CoA-SH

benzoyl-S-CoA + CO2 + FADH2

Aromatoleum evansii

-

-

11535

-

-

?

phenylglyoxylate + FMN + CoA-SH

benzoyl-S-CoA + CO2 + FMNH

Aromatoleum evansii

-

-

11535

-

-

?

phenylglyoxylate + methyl viologen + CoA-SH

benzoyl-S-CoA + CO2 + reduced methyl viologen

Aromatoleum evansii

-

-

11535

-

-

?

phenylglyoxylate + NAD+ + CoA-SH

benzoyl-S-CoA + CO2 + NADH

5 entries

additional information

?

-

Aromatoleum evansii

-

enzyme catalyzes a NAD(H):viologen dye transhydrogenation

11535

-

-

?

phenylglyoxylate + benzyl viologen + CoA-SH

benzoyl-S-CoA + CO2 + reduced benzyl viologen

Aromatoleum evansii

-

-

11535

-

11535

?

phenylglyoxylate + benzyl viologen + CoA-SH

benzoyl-S-CoA + CO2 + reduced benzyl viologen

Thauera aromatica

-

-

718

-

718

?

phenylglyoxylate + NAD+ + CoA-SH

benzoyl-S-CoA + CO2 + NADH

Aromatoleum evansii

-

reaction is strictly dependent on CoA

11535

-

11535

?

phenylglyoxylate + NAD+ + CoA-SH

benzoyl-S-CoA + CO2 + NADH

Aromatoleum evansii

-

enzyme activity is induced during anaerobic growth with Phe, phenylacetate and phenylglyoxylate, but not with benzoate

11535

-

-

?

phenylglyoxylate + NAD+ + CoA-SH

benzoyl-S-CoA + CO2 + NADH

Aromatoleum evansii

-

enzyme of anaerobic Phe metabolism

11535

-

-

?

phenylglyoxylate + NAD+ + CoA-SH

benzoyl-S-CoA + CO2 + NADH

Thauera aromatica

-

NADP+ can substitute for NAD+

718

-

718

?

phenylglyoxylate + NAD+ + CoA-SH

benzoyl-S-CoA + CO2 + NADH

Thauera aromatica

-

enzyme of anaerobic Phe metabolism

718

-

-

?