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1.2.1.48: long-chain-aldehyde dehydrogenase

This is an abbreviated version!
For detailed information about long-chain-aldehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.48

Reaction

a long-chain aldehyde
+
NAD+
+
H2O
=
a long-chain carboxylate
+
NADH
+
H+

Synonyms

ALDH, ALDH10, ALDH3A2, Aldh3b1, ALDH3B2, ALDH3B3, Bt-Aldh, dehydrogenase, long-chain aliphatic aldehyde, FAldDH, FALDH, fatty aldehyde dehydrogenase, fatty aldehyde:NAD+ oxidoreductase, long-chain aldehyde dehydrogenase, long-chain fatty aldehyde dehydrogenase, long-chain-aldehyde dehydrogenase, membrane-bound fatty aldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.48 long-chain-aldehyde dehydrogenase

Reference

Reference on EC 1.2.1.48 - long-chain-aldehyde dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Moreau, R.A.; Huang, A.H.C.
Enzymes of wax ester catabolism in jojoba
Methods Enzymol.
71
804-813
1981
Simmondsia chinensis
-
Manually annotated by BRENDA team
Yamada, T.; Nawa, H.; Kawamoto, S.; Tanaka, A.; Fukui, S.
Subcellular localization of long-chain alcohol dehydrogenase and aldehyde dehydrogenase in n-alkane-grown Candida tropicalis
Arch. Microbiol.
128
145-151
1980
Candida tropicalis
Manually annotated by BRENDA team
Moreau, R.A.; Huang, A.H.C.
Oxidation of fatty alcohol in the cotyledons of jojoba seedlings
Arch. Biochem. Biophys.
194
422-430
1979
Simmondsia chinensis
Manually annotated by BRENDA team
Jenkins, R.O.; Cartledge, T.G.; Lloyd, D.
Subcellular fractionation of Candida stellatoidea after growth with glucose or n-hexadecane
J. Gen. Microbiol.
129
1171-1185
1983
Candida albicans
-
Manually annotated by BRENDA team
Meighen, E.A.; Bogacki, I.G.; Bognar, A.; Michaliszyn, G.A.
Induction of fatty aldehyde dehydrogenase activity during the development of bioluminescence in Beneckea harveyi
Biochem. Biophys. Res. Commun.
69
423-430
1976
Vibrio harveyi
Manually annotated by BRENDA team
Ueda, M.; Tanaka, A.
Long-chain aldehyde dehydrogenase of Candida Yeast
Methods Enzymol.
188
176-178
1990
Yarrowia lipolytica, Candida tropicalis
Manually annotated by BRENDA team
Kelson, T.L.; Secor McVoy, J.R.; Rizzo, W.B.
Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization
Biochim. Biophys. Acta
1335
99-110
1997
Homo sapiens
Manually annotated by BRENDA team
Ishige, T.; Tani, A.; Sakai, Y.; Kato, N.
Long-chain aldehyde dehydrogenase that participates in n-alkane utilization and wax ester synthesis in Acinetobacter sp. strain M-1
Appl. Environ. Microbiol.
66
3481-3486
2000
Acinetobacter sp., Acinetobacter sp. M-1
Manually annotated by BRENDA team
Ahvazi, B.; Coulombe, R.; Delarge, M.; Vedadi, M.; Zhang, L.; Meighen, E.; Vrielink, A.
Crystal structure of the NADP+-dependent aldehyde dehydrogenase from Vibrio harveyi: structural implications for cofactor specificity and affinity
Biochem. J.
349
853-861
2000
Vibrio harveyi
Manually annotated by BRENDA team
Croteau, N.; Vedadi, M.; Delarge, M.; Meighen, E.; Abu-Abed, M.; Howell P.L.; Vrielink, A.
Crystallization and preliminary X-ray analysis of aldehyde dehydrogenase from Vibrio harveyi
Protein Sci.
5
2130-2132
1996
Vibrio harveyi
Manually annotated by BRENDA team
Carney, G.; Wei, S.; Rizzo, W.B.
Sjogren-Larsson syndrome: seven novel mutations in the fatty aldehyde dehydrogenase gene ALDH3A2
Hum. Mutat.
24
186
2004
Homo sapiens
Manually annotated by BRENDA team
Demozay, D.; Rocchi, S.; Mas, J.C.; Grillo, S.; Pirola, L.; Chavey, C.; Van Obberghen, E.
Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin
J. Biol. Chem.
279
6261-6270
2004
Rattus norvegicus
Manually annotated by BRENDA team
van den Brink, D.M.; van Miert, J.N.; Dacremont, G.; Rontani, J.F.; Jansen, G.A.; Wanders, R.J.
Identification of fatty aldehyde dehydrogenase in the breakdown of phytol to phytanic acid
Mol. Genet. Metab.
82
33-37
2004
Homo sapiens
Manually annotated by BRENDA team
Rizzo, W.B.; Carney, G.
Sjoegren-Larsson syndrome: diversity of mutations and polymorphisms in the fatty aldehyde dehydrogenase gene (ALDH3A2)
Hum. Mutat.
26
1-10
2005
Homo sapiens
Manually annotated by BRENDA team
Gloerich, J.; Ijlst, L.; Wanders, R.J.; Ferdinandusse, S.
Bezafibrate induces FALDH in human fibroblasts; implications for Sjoegren-Larsson syndrome
Mol. Genet. Metab.
89
111-115
2006
Homo sapiens
Manually annotated by BRENDA team
Rizzo, W.B.
Sjoegren-Larsson syndrome: Molecular genetics and biochemical pathogenesis of fatty aldehyde dehydrogenase deficiency
Mol. Genet. Metab.
90
1-9
2007
Homo sapiens
Manually annotated by BRENDA team
Lloyd, M.D.; Boardman, K.D.; Smith, A.; van den Brink, D.M.; Wanders, R.J.; Threadgill, M.D.
Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjoegren-Larsson syndrome
J. Enzyme Inhib. Med. Chem.
22
584-590
2007
Homo sapiens
Manually annotated by BRENDA team
Kato, T.; Miyanaga, A.; Kanaya, S.; Morikawa, M.
Gene cloning and characterization of an aldehyde dehydrogenase from long-chain alkane-degrading Geobacillus thermoleovorans B23
Extremophiles
14
33-39
2009
Geobacillus thermoleovorans (Q9FAB1), Geobacillus thermoleovorans B23 (Q9FAB1)
Manually annotated by BRENDA team
Kitamura, T.; Naganuma, T.; Abe, K.; Nakahara, K.; Ohno, Y.; Kihara, A.
Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1
Biochim. Biophys. Acta
1831
1395-1401
2013
Homo sapiens
Manually annotated by BRENDA team
Keller, M.; Watschinger, K.; Golderer, G.; Maglione, M.; Sarg, B.; Lindner, H.; Werner-Felmayer, G.; Terrinoni, A.; Wanders, R.; Werner, E.
Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal
J. Lipid Res.
51
1554-1559
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kitamura, T.; Takagi, S.; Naganuma, T.; Kihara, A.
Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification
Biochem. J.
465
79-87
2015
Mus musculus (E9Q3E1), Mus musculus (J3QMK6), Mus musculus
Manually annotated by BRENDA team
Keller, M.A.; Zander, U.; Fuchs, J.E.; Kreutz, C.; Watschinger, K.; Mueller, T.; Golderer, G.; Liedl, K.R.; Ralser, M.; Kraeutler, B.; Werner, E.R.; Marquez, J.A.
A gatekeeper helix determines the substrate specificity of Sjoegren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase
Nat. Commun.
5
4439
2014
Homo sapiens (P51648), Homo sapiens
Manually annotated by BRENDA team
Bertram, J.H.; Mulliner, K.M.; Shi, K.; Plunkett, M.H.; Nixon, P.; Serratore, N.A.; Douglas, C.J.; Aihara, H.; Barney, B.M.
Five fatty aldehyde dehydrogenase enzymes from Marinobacter and Acinetobacter spp. and structural insights into the aldehyde binding pocket
Appl. Environ. Microbiol.
83
e00018-17
2017
Marinobacter nauticus
Manually annotated by BRENDA team
Tao, X.; Zhang, Z.; Zhang, X.; Li, H.; Sun, H.; Mao, Z.; Xia, W.
Structural insight into the substrate gating mechanism by Staphylococcus aureus aldehyde dehydrogenase
CCS Chem.
2
946-954
2020
Staphylococcus aureus
-
Manually annotated by BRENDA team
Kitamura, T.; Seki, N.; Kihara, A.
Phytosphingosine degradation pathway includes fatty acid alpha-oxidation reactions in the endoplasmic reticulum
Proc. Natl. Acad. Sci. USA
114
E2616-E2623
2017
Cricetulus griseus
Manually annotated by BRENDA team