1.2.1.42: hexadecanal dehydrogenase (acylating)
This is an abbreviated version!
For detailed information about hexadecanal dehydrogenase (acylating), go to the full flat file.
Word Map on EC 1.2.1.42
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1.2.1.42
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acyl-coas
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photobacterium
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harveyi
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phosphoreum
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fischeri
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tetradecanoic
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marinobacter
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luxcde
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1-hexadecanol
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luxab
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leiognathi
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luciferase-catalyzed
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jojoba
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acyl-protein
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aquaeolei
- 1.2.1.42
- acyl-coas
- photobacterium
- harveyi
- phosphoreum
- fischeri
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tetradecanoic
- marinobacter
-
luxcde
- 1-hexadecanol
- luxab
- leiognathi
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luciferase-catalyzed
- jojoba
-
acyl-protein
- aquaeolei
Reaction
Synonyms
ACIAD3383, Acr1, AtFAR2, CoA-acylating aldehyde dehydrogenase, coenzyme A-acylating aldehyde dehydrogenase, dehydrogenase, hexadecanal (acylating), FACoAR, FAR, FAR1, FAR2, FAR6, fatty acid reductase, fatty acyl-CoA reductase, MS2, PduP
ECTree
1.2.1.42 hexadecanal dehydrogenase (acylating)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.2.1.42 - hexadecanal dehydrogenase (acylating)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
a fatty acyl-CoA + 2 NADPH + 2 H+
a fatty aldehyde + CoA + 2 NADP+
-
-
-
?
arachidonoyl-CoA + NADPH + H+
arachidonic aldehyde + CoA + NADP+
Marinobacter nauticus
-
86% activity compared to hexadecanoyl-CoA
-
-
?
cis-11-hexadecenal + CoA + NADP+
(E)-hexadec-11-enoyl-CoA + NADPh + H+
Marinobacter nauticus
-
-
-
-
?
decanoyl-CoA + NAD(P)H
decanal + NAD(P)+
-
2.5% of activity with tetradecanoyl-CoA
-
?
dodecanoyl-CoA + NAD(P)H
dodecanal + NAD(P)+
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33% of activity with tetradecanoyl-CoA
-
?
dodecanoyl-CoA + NADPH + H+
dodecanal + CoA + NADP+
Marinobacter nauticus
-
26% activity compared to hexadecanoyl-CoA
-
-
?
eicosanoyl-CoA + NAD(P)H
eicosanal + NAD(P)+
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2.5% of activity with tetradecanoyl-CoA
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?
hexadecanoyl-CoA + NADH
hexadecanal + NAD+ + CoA
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reduction of NAD+ is at most 5% of the rate of NADH oxidoreduction, the enzyme is primarily a reductase and not an aldehyde dehydrogenase
-
?
octadecanoyl-CoA + NAD(P)H
octadecanal + NAD(P)+
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44% of activity with tetradecanoyl-CoA
-
?
octadecanoyl-CoA + NADH
octadecanal + NAD+ + CoA
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slowly, octadecanoyl-CoA is identical with stearoyl-CoA
-
-
?
octanoyl-CoA + NADPH + H+
octanal + CoA + NADP+
Marinobacter nauticus
-
9% activity compared to hexadecanoyl-CoA
-
-
?
oleoyl-CoA + NADPH + H+
oleic aldehyde + CoA + NADP+
Marinobacter nauticus
-
78% activity compared to hexadecanoyl-CoA
-
-
?
palmitoleoyl-CoA + NADPH + H+
palmitoleic aldehyde + CoA + NADP+
Marinobacter nauticus
-
99% activity compared to hexadecanoyl-CoA
-
-
?
[hexadecanoyl]-acyl carrier protein + NADPH + H+
?
-
preferred substrate
-
-
?
2-methyl-1-hexadecanoyl-CoA + NADPH + H+
2-methyl-1-hexadecanal + CoA + NADP+
-
-
-
-
?
2-methyl-1-hexadecanoyl-CoA + NADPH + H+
2-methyl-1-hexadecanal + CoA + NADP+
-
-
-
-
?
2-methyl-1-hexadecanoyl-CoA + NADPH + H+
2-methyl-1-hexadecanal + CoA + NADP+
-
-
-
-
?
docosanoyl-CoA + NADPH
docosanal + NADP+
-
12.7% of activity with hexadecanoyl-CoA
-
?
docosanoyl-CoA + NADPH
docosanal + NADP+
-
12.7% of activity with hexadecanoyl-CoA
-
?
eicosanoyl-CoA + NADPH
eicosanal + NADP+
-
7.8% of activity with hexadecanoyl-CoA
-
?
eicosanoyl-CoA + NADPH
eicosanal + NADP+
-
7.8% of activity with hexadecanoyl-CoA
-
?
hexadecanoyl-CoA + NAD(P)H
hexadecanal + NAD(P)+
-
90% of activity with tetradecanoyl-CoA
-
?
hexadecanoyl-CoA + NAD(P)H
hexadecanal + NAD(P)+
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NADH gives almost 60% of the activity obtained with NADPH, after palmitoyl-CoA affinity column purification enzyme is absolutely dependent on NADPH as cofactor
-
?
hexadecanoyl-CoA + NADPH + H+
1-hexadecanal + CoA + NADP+
-
preferred substrate
-
-
?
hexadecanoyl-CoA + NADPH + H+
1-hexadecanal + CoA + NADP+
-
preferred substrate
-
-
?
hexadecanoyl-CoA + NADPH + H+
1-hexadecanal + CoA + NADP+
Marinobacter nauticus
-
100% activity
-
-
?
hexadecanoyl-CoA + NADPH + H+
1-hexadecanal + CoA + NADP+
-
preferred substrate
-
-
?
hexadecanoyl-CoA + NADPH + H+
hexadecanal + CoA + NADP+
-
-
-
?
hexadecanoyl-CoA + NADPH + H+
hexadecanal + CoA + NADP+
-
-
-
?
hexadecanoyl-CoA + NADPH + H+
hexadecanal + CoA + NADP+
highest activity
-
-
?
hexadecanoyl-CoA + NADPH + H+
hexadecanal + CoA + NADP+
-
preferred substrate
-
-
?
hexadecanoyl-CoA + NADPH + H+
hexadecanal + CoA + NADP+
-
24% conversion efficiency
-
-
?
octadecanoyl-CoA + NADPH + H+
octadecanal + CoA + NADP+
-
77.2% of activity with hexadecanoyl-CoA
-
?
octadecanoyl-CoA + NADPH + H+
octadecanal + CoA + NADP+
-
77.2% of activity with hexadecanoyl-CoA
-
?
octadecanoyl-CoA + NADPH + H+
octadecanal + CoA + NADP+
-
-
-
?
octadecanoyl-CoA + NADPH + H+
octadecanal + CoA + NADP+
-
low activity
-
-
?
octadecanoyl-CoA + NADPH + H+
octadecanal + CoA + NADP+
Marinobacter nauticus
-
69% activity compared to hexadecanoyl-CoA
-
-
?
tetradecanoyl-CoA + NADPH + H+
tetradecanal + CoA + NADP+
-
65.1% of activity with hexadecanoyl-CoA
-
?
tetradecanoyl-CoA + NADPH + H+
tetradecanal + CoA + NADP+
-
65.1% of activity with hexadecanoyl-CoA
-
?
tetradecanoyl-CoA + NADPH + H+
tetradecanal + CoA + NADP+
-
-
-
?
tetradecanoyl-CoA + NADPH + H+
tetradecanal + CoA + NADP+
-
preferred substrate, 34% conversion efficiency
-
-
?
tetradecanoyl-CoA + NADPH + H+
tetradecanal + CoA + NADP+
Marinobacter nauticus
-
60% activity compared to hexadecanoyl-CoA
-
-
?
additional information
?
-
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the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA
-
-
?
additional information
?
-
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no products are detected when using C18:1-CoA, 2-methyl-16:0-CoA, 2-methyl-18:0-CoA or C16:0 free fatty acid as substrates
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-
?
additional information
?
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Arabidopsis thaliana AtFAR2 has the ability to use both, C16:0-ACP and C16:0-CoA substrates for the production of C16:0- alcohol, purified enzyme AtFAR2 is specific for acyl-ACP substrates, AtFAR2 shows the highest activity towards C16:0-CoA, approximately 11times higher in comparison to the activity towards C18:0-CoA. AtFAR2 displays a very low activity with C18:1-CoA, and application of C14:0-CoA as a substrate generates only aldehyde and free fatty acid
-
-
?
additional information
?
-
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Arabidopsis thaliana AtFAR2 has the ability to use both, C16:0-ACP and C16:0-CoA substrates for the production of C16:0- alcohol, purified enzyme AtFAR2 is specific for acyl-ACP substrates, AtFAR2 shows the highest activity towards C16:0-CoA, approximately 11times higher in comparison to the activity towards C18:0-CoA. AtFAR2 displays a very low activity with C18:1-CoA, and application of C14:0-CoA as a substrate generates only aldehyde and free fatty acid
-
-
?
additional information
?
-
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the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA
-
-
?
additional information
?
-
Marinobacter nauticus
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the enzyme exhibits no detectable reduction with free fatty acids, less than 1% activity with acetaldehyde and propanal
-
-
?
additional information
?
-
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substrate chain length specificity of the enzyme is C2-C12, highest activity with C12 substrate, overview. The overall activity of the enzyme is low compared to other PduP enzymes
-
-
?
