1.2.1.39: phenylacetaldehyde dehydrogenase

This is an abbreviated version!
For detailed information about phenylacetaldehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.39

Reaction

phenylacetaldehyde
+
NAD+
+
H2O
=
phenylacetate
+
NADH
+ 2 H+

Synonyms

dehydrogenase, phenylacetaldehyde, ebA4954, feaB, NPADH, PAAL dehydrogenase, PAD, PadA, PADH, PDH, PeaE, PeaE protein, phenylacetaldehyde dehydrogenase, styD

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.39 phenylacetaldehyde dehydrogenase

Specific Activity

Specific Activity on EC 1.2.1.39 - phenylacetaldehyde dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.102
purified native enzyme, with cofactor NADP+, pH 8.5, 28°C
0.21
purified recombinant Strep-tagged enzyme, pH 8.5, 28°C
0.261
-
cell-free extract
4.16
-
15.9fold purified enzyme
19
Achromobacter eurydice
-
-
additional information
B1N7H3
Analysis of phenylacetaldehyde dehydrogenase activity in cell-free extracts reveals that although enzymatic activity decreases in the peaE knocked-out mutant (20% with respect to the control), good phenylacetaldehyde dehydrogenase activity is present. Another aldehyde dehydrogenase(s) exist(s) that could replace the role played by PeaE