1.2.1.39: phenylacetaldehyde dehydrogenase

This is an abbreviated version, for detailed information about phenylacetaldehyde dehydrogenase, go to the full flat file.

Reaction

phenylacetaldehyde
+
NAD+
+
H2O
=
phenylacetate
+
NADH
+ 2 H+

Synonyms

dehydrogenase, phenylacetaldehyde, ebA4954, feaB, NPADH, PAAL dehydrogenase, PAD, PadA, PADH, PDH, PeaE, PeaE protein, phenylacetaldehyde dehydrogenase, styD

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.39 phenylacetaldehyde dehydrogenase

Inhibitors

Inhibitors on EC 1.2.1.39 - phenylacetaldehyde dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3,4-dihydroxyphenylacetaldehyde
-
above 0.01 mM
4-hydroxyphenylacetaldehyde
-
above 0.01 mM
8-Quinolinol
-
34% inhibition in the presence of 1 mM
Ba2+
-
19% inhibition in the presence of 1 mM
Cu2+
-
44% inhibition in the presence of 1 mM
EDTA
-
18% inhibition in the presence of 1 mM
Hg2+
-
77% inhibition in the presence of 1 mM
hydrozine
-
51% inhibition in the presence of 1 mM
iodoacetamide
-
completely inhibits in the presence of 1 mM
iodoacetate
-
18% inhibition in the presence of 1 mM
K+
Achromobacter eurydice
-
above 1 M
Mn2+
inhibits and activates
N-ethylmaleimide
Achromobacter eurydice
-
-
N-ethylmaleinimide
-
completely inhibits in the presence of 1 mM
NADH
product inhibition, competitive binding of NAD+. For many aldehyde dehydrogenases, NADH binds competitively with NAD+ and forms a nonproductive dead-end complex during catalysis. In the absence of styrene monooxygenase reductase, which regenerates NAD+ from NADH in the first step of styrene catabolism, NPADH is inhibited by a ternary complex involving NADH, product, and phenylacetaldehyde, substrate
NADP+
cooperative substrate inhibition
NaN3
-
25% inhibition in the presence of 1 mM
Ni2+
-
12% inhibition in the presence of 1 mM
p-chloromercuribenzoate
phenylacetaldehyde
PMSF
inactivates NPADH, presumably by modifying the active site cysteine
Pyridine nucleotides
titrations of NPADH with NADþ and NADH are evaluated to estimate the binding affinities of the oxidized and reduced pyridine nucleotides under equilibrium conditions. Mg2+ is included in these studies
-
Zn2+
-
41% inhibition in the presence of 1 mM