1.2.1.32: aminomuconate-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about aminomuconate-semialdehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-aminomuconate semialdehyde dehydrogenase, 2-aminomuconate-6-semialdehyde dehydrogenase, 2-aminomuconic 6-semialdehyde dehydrogenase, 2-AMS dehydrogenase, 2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, 2-hydroxymuconic 6-semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, aldehyde dehydrogenase, ALDH12, Aldh8a1, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, AMDH, aminomuconate semialdehyde dehydrogenase, aminomuconate-semialdehyde dehydrogenase, AMSDH, dehydrogenase, 2-hydroxymuconate semialdehyde, dehydrogenase, aminomuconate semialdehyde, HMSD-2, nbaE

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.32 aminomuconate-semialdehyde dehydrogenase

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Results	in table
1	Activating Compound
339	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
21	Cofactor
1	Crystallization (Commentary)
7	General Information
22	Inhibitors
2	kcat/KM [mM/s]
2	Ki Value [mM]
38	KM Value [mM]
12	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
152	Organism
9	Pathway
2	PDB ID
6	pH Optimum
2	pH Range
1	pI Value
10	Protein Variants
14	Purification (Commentary)
3	Reaction
7	Reaction Type
42	Reference
4	Source Tissue
11	Specific Activity [micromol/min/mg]
1	Storage Stability
127	Substrates and Products (Substrate)
12	Subunits
34	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.2.1.32 - aminomuconate-semialdehyde dehydrogenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2-aminomuconate 6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + 2 H+

3 entries

2-aminomuconate 6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + H+

3 entries

2-aminomuconate-6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH

4 entries

2-hydroxymuconate-6-semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH

Bordetella sp.

-

-

672682

-

-

?

2-hydroxymuconate-6-semialdehyde + NAD+ + H2O

4-oxalocrotonate + NADH + H+

2 entries

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

12 entries

2-aminomuconate 6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + 2 H+

Homo sapiens

Q9H2A2

-

763259

-

-

?

2-aminomuconate 6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + 2 H+

Pseudomonas fluorescens

Q83V33

-

743338

-

-

?

2-aminomuconate 6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + 2 H+

Pseudomonas fluorescens KU-7

Q83V33

-

743338

-

-

?

2-aminomuconate 6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + H+

Bordetella sp.

-

-

672682

-

-

?

2-aminomuconate 6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + H+

Burkholderia cepacia

-

-

669112

-

-

?

2-aminomuconate 6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH + H+

Burkholderia cepacia J2315

-

-

669112

-

-

?

2-aminomuconate-6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH

Felis catus

-

metabolism of benzene ring of tryptophan in mammalian tissues

4568

-

4568

?

2-aminomuconate-6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH

Pseudomonas oleovorans

-

catabolism of nitrobenzene as sole source of carbon, nitrogen and energy

172187

-

172187

?

2-aminomuconate-6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH

Pseudomonas oleovorans

-

catabolism of nitrobenzene as sole source of carbon, nitrogen and energy

390254

-

390254

?

2-aminomuconate-6-semialdehyde + NAD+ + H2O

2-aminomuconate + NADH

Pseudomonas oleovorans JS45

-

catabolism of nitrobenzene as sole source of carbon, nitrogen and energy

172187

-

172187

?

2-hydroxymuconate-6-semialdehyde + NAD+ + H2O

4-oxalocrotonate + NADH + H+

Burkholderia cepacia

Q83XU8

involved in meta cleavage pathway of aromatic hydrocarbons

654394

-

-

?

2-hydroxymuconate-6-semialdehyde + NAD+ + H2O

4-oxalocrotonate + NADH + H+

Burkholderia cepacia G4

Q83XU8

involved in meta cleavage pathway of aromatic hydrocarbons

654394

-

-

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Cupriavidus necator

-

dissimilatory meta-cleavage of catechols

4834

-

4834

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Cupriavidus necator 345

-

dissimilatory meta-cleavage of catechols

4834

-

4834

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Cupriavidus necator RA1012

-

dissimilatory meta-cleavage of catechols

4834

-

4834

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Pseudomonas putida

-

-

390225

-

390225

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Pseudomonas putida

-

dissimilatory meta-cleavage of catechols

390246

-

390246

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Pseudomonas putida

-

dissimilatory meta-cleavage of catechols

390247

-

390247

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Pseudomonas putida

-

dissimilatory meta-cleavage of catechols

390249

-

390249

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182

-

dissimilatory meta-cleavage of catechols

390247

-

390247

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182

-

dissimilatory meta-cleavage of catechols

390249

-

390249

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Pseudomonas putida NCIB 10015

-

dissimilatory meta-cleavage of catechols

390246

-

390246

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Pseudomonas sp.

-

-

390256

-

390256

?

2-hydroxymuconic acid semialdehyde + NAD+ + H2O

2-hydroxymuconate + NADH + H+

Pseudomonas sp.

-

dissimilatory meta-cleavage of catechols

390250

-

390250

?