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1.2.1.30: carboxylate reductase (NADP+)

This is an abbreviated version!
For detailed information about carboxylate reductase (NADP+), go to the full flat file.

Word Map on EC 1.2.1.30

Reaction

an aromatic aldehyde
+
NADP+
+
AMP
+
diphosphate
=
an aromatic acid
+
NADPH
+
H+
+
ATP

Synonyms

aromatic acid reductase, aryl aldehyde:NADP+ oxidoreductase, aryl-aldehyde dehydrogenase (NADP+), aryl-aldehyde oxidoreductase, ATP/NADPH-dependent carboxylic acid reductase, CAR, carboxylate reductase, carboxylate reductases, Carboxylic acid reductase, kaCAR, mab3CAR, maCAR, mmCAR, mpCAR, msCAR, naCAR, NcCAR, niCAR, noCAR, tpCAR, type I CAR, type III CAR

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.30 carboxylate reductase (NADP+)

Engineering

Engineering on EC 1.2.1.30 - carboxylate reductase (NADP+)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E697Q
-
site-directed mutagenesis, the mutant enzyme retains 48.8% of wild-type activity with benzoate substrate
Q637E
-
site-directed mutagenesis, the mutant enzyme retains 47.1% of wild-type activity with benzoate substrate
A922G
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
E337A
E433A
E441A
site-directed mutagenesis, the enzyme shows altered substrate specificity compared to wild-type
F787A
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
G432A
-
site-directed mutagenesis, the mutant shows activity similar to wild-type
G457A
site-directed mutagenesis, the enzyme shows altered substrate specificity compared to wild-type
G592A
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
G691A
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
G694A
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
G697A
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
G755A
site-directed mutagenesis, the mutant has activity similar to wild-type
G843A
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
G882A
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
H237A
K190A
-
site-directed mutagenesis, the mutant shows increased activity compared to wild-type
K848A
N885A
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
P189A
-
site-directed mutagenesis, the mutant shows activity similar to wild-type
P198A
site-directed mutagenesis, the enzyme shows altered substrate specificity compared to wild-type
P234A
P285A
site-directed mutagenesis, the enzyme shows altered substrate specificity compared to wild-type
P904A
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
S595A
site-directed mutagenesis, inactive mutant
T186A
-
site-directed mutagenesis, the mutant shows activity similar to wild-type
Y542A
site-directed mutagenesis, the enzyme shows reduced activity compared to wild-type
Y844A
E433A
-
site-directed mutagenesis, inactive mutant
-
H237A
-
site-directed mutagenesis, inactive mutant
-
P285A
-
site-directed mutagenesis, the enzyme shows altered substrate specificity compared to wild-type
-
S595A
-
site-directed mutagenesis, inactive mutant
-
E433A
-
site-directed mutagenesis, inactive mutant
-
H237A
-
site-directed mutagenesis, inactive mutant
-
P285A
-
site-directed mutagenesis, the enzyme shows altered substrate specificity compared to wild-type
-
S595A
-
site-directed mutagenesis, inactive mutant
-
E433A
-
site-directed mutagenesis, inactive mutant
-
H237A
-
site-directed mutagenesis, inactive mutant
-
P285A
-
site-directed mutagenesis, the enzyme shows altered substrate specificity compared to wild-type
-
S595A
-
site-directed mutagenesis, inactive mutant
-
E433A
-
site-directed mutagenesis, inactive mutant
-
H237A
-
site-directed mutagenesis, inactive mutant
-
P285A
-
site-directed mutagenesis, the enzyme shows altered substrate specificity compared to wild-type
-
S595A
-
site-directed mutagenesis, inactive mutant
-
E433A
-
site-directed mutagenesis, inactive mutant
-
H237A
-
site-directed mutagenesis, inactive mutant
-
P285A
-
site-directed mutagenesis, the enzyme shows altered substrate specificity compared to wild-type
-
S595A
-
site-directed mutagenesis, inactive mutant
-
S689A
-
completely inactive
S691A
-
has 39% of the activity of recombinant car
S694A
-
has 50% of the activity of recombinant car
S696A
-
has 76% of the activity of recombinant car
additional information