1.2.1.24: succinate-semialdehyde dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase (NAD+), go to the full flat file.
Word Map on EC 1.2.1.24
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1.2.1.24
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aldhs
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gamma-hydroxybutyric
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ssadhd
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4-hydroxybutyric
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propionaldehyde
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trans-4-hydroxy-2-nonenal
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aldh4a1
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akr7a2
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ssadh-deficient
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medicine
- 1.2.1.24
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aldhs
-
gamma-hydroxybutyric
-
ssadhd
-
4-hydroxybutyric
- propionaldehyde
- trans-4-hydroxy-2-nonenal
- aldh4a1
-
akr7a2
-
ssadh-deficient
- medicine
Reaction
Synonyms
aldehyde dehydrogenase 5a1, ALDH5A, ALDH5A1, alphaKGSA dehydrogenase, dehydrogenase, succinate semialdehyde, NAD(+)-dependent succinic semialdehyde dehydrogenase, SSADH, SSADH-I, SSADH/ALDH5A1, SSALDH, SSO1629, succinate semialdehyde dehydrogenase, succinate semialdehyde:NAD+ oxidoreductase, succinic semialdehyde dehydrogenase, succinyl semialdehyde dehydrogenase, YneI dehydrogenase
ECTree
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Substrates Products
Substrates Products on EC 1.2.1.24 - succinate-semialdehyde dehydrogenase (NAD+)
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REACTION DIAGRAM
2,5-dioxopentanoate + NAD+ + H2O
?
no activity in presence of NADP+
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-
?
2-carboxybenzaldehyde + NAD+ + H2O
2-carboxybenzoate + NADH + H+
about 1% activity compared to succinate semialdehyde
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-
?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
about 1% activity compared to succinate semialdehyde
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-
?
2-nitrobenzaldehyde + NAD+ + H2O
2-nitrobenzoate + NADH + H+
about 3% activity compared to succinate semialdehyde
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-
?
2-phenylacetaldehyde + NAD+ + H2O
2-phenylbenzoate + NADH + H+
about 5% activity compared to succinate semialdehyde
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-
?
2-tolualdehyde + NAD+ + H2O
2-carboxytoluene + NADH + H+
about 1% activity compared to succinate semialdehyde
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-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
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low activity
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-
?
4-hydroxy-trans-2-nonenal + NAD+
?
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elevated levels of 4-hydroxy-trans-2-nonenal are implicated in the pathogenesis of numerous neurodegenerative disorders. Succinate-semialdehyde dehydrogenase is the predominant oxidizing enzyme for 4-hydroxy-trans-2-nonenal but only contributes a portion of the total oxidizing activity in liver mitochondria
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-
?
alpha-ketoglutaric semialdehyde + NAD+ + H2O
alpha-ketoglutarate + NADH
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-
-
?
alpha-ketoglutaric semialdehyde + NADP+ + H2O
alpha-ketoglutarate + NADPH
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-
-
?
betaine aldehyde + NAD+ + H2O
2-trimethylammonioacetate + NADH
-
-
-
?
glyoxylic acid + NAD+ + H2O
2-phenylbenzoate + NADH + H+
about 1% activity compared to succinate semialdehyde
-
-
?
iso-butanal + NAD+ + H2O
? + NADH + H+
less than 10% activity compared to succinate semialdehyde
-
-
?
iso-butanal + NAD+ + H2O
isobutanoate + NADH + H+
-
less than 10% activity compared to succinate semialdehyde
-
-
?
iso-pentanal + NAD+ + H2O
? + NADH + H+
about 2% activity compared to succinate semialdehyde
-
-
?
iso-pentanal + NAD+ + H2O
isopentanoate + NADH + H+
-
less than 5% activity compared to succinate semialdehyde
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-
?
m-carboxybenzaldehyde + NAD+ + H2O
m-carboxybenzoate + NADH + H+
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-
-
?
m-methylcarboxybenzaldehyde + NAD+ + H2O
m-methylcarboxybenzoate + NADH + H+
-
-
-
?
m-nitrobenzaldehyde + NAD+ + H2O
m-nitrobenzoate + NADH
-
4.3% of the activity with succinate semialdehyde
-
-
?
malonate semialdehyde + NAD+ + H2O
malonate + NADH + 2 H+
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3.8% of the activity with succinate semialdehyde
-
-
?
n-butanal + NAD+ + H2O
butanoic acid + NADH + 2 H+
-
about 11% of the rate with succinic semialdehyde
-
-
?
succinate semialdehyde + 3-acetylpyridine adenine dinucleotide + H2O
succinate + reduced 3-acetylpyridine adenine dinucleotide + H+
-
-
-
-
r
3-carboxybenzoate + NAD(P)H + H+
-
-
-
-
?
3-carboxybenzaldehyde + NAD(P)+ + H2O
3-carboxybenzoate + NAD(P)H + H+
-
-
-
?
3-carboxybenzoate + NADH + H+
about 20% activity compared to succinate semialdehyde
-
-
?
3-carboxybenzaldehyde + NAD+ + H2O
3-carboxybenzoate + NADH + H+
-
about 35% activity compared to succinate semialdehyde
-
-
?
3-hydroxybenzoate + NADH + H+
about 1% activity compared to succinate semialdehyde
-
-
?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
about 2% activity compared to succinate semialdehyde
-
-
?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
-
about 3% activity compared to succinate semialdehyde
-
-
?
3-methoxy-benzoate + NADH + H+
about 5% activity compared to succinate semialdehyde
-
-
?
3-methoxy-benzaldehyde + NAD+ + H2O
3-methoxy-benzoate + NADH + H+
-
about 10% activity compared to succinate semialdehyde
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-
?
3-methylbenzoate + NADH + H+
about 3% activity compared to succinate semialdehyde
-
-
?
3-methylbenzaldehyde + NAD+ + H2O
3-methylbenzoate + NADH + H+
-
about 10% activity compared to succinate semialdehyde
-
-
?
3-nitrobenzoate + NADH + H+
about 20% activity compared to succinate semialdehyde
-
-
?
3-nitrobenzaldehyde + NAD+ + H2O
3-nitrobenzoate + NADH + H+
-
about 15% activity compared to succinate semialdehyde
-
-
?
4-carboxybenzoate + NAD(P)H + H+
-
-
-
-
?
4-carboxybenzaldehyde + NAD(P)+ + H2O
4-carboxybenzoate + NAD(P)H + H+
-
-
-
?
4-carboxybenzoate + NADH + H+
about 10% activity compared to succinate semialdehyde
-
-
?
4-carboxybenzaldehyde + NAD+ + H2O
4-carboxybenzoate + NADH + H+
-
about 65% activity compared to succinate semialdehyde
-
-
?
4-hydroxy-trans-2-nonenoate + NADH + H+
-
-
-
?
4-hydroxy-trans-2-nonenal + NAD+ + H2O
4-hydroxy-trans-2-nonenoate + NADH + H+
-
-
-
-
?
4-hydroxy-trans-2-nonenal + NAD+ + H2O
4-hydroxy-trans-2-nonenoate + NADH + H+
-
-
-
-
?
4-methoxy-benzoate + NADH + H+
about 1% activity compared to succinate semialdehyde
-
-
?
4-methoxy-benzaldehyde + NAD+ + H2O
4-methoxy-benzoate + NADH + H+
-
about 5% activity compared to succinate semialdehyde
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-
?
4-nitrobenzoate + NADH + H+
about 15% activity compared to succinate semialdehyde
-
-
?
4-nitrobenzaldehyde + NAD+ + H2O
4-nitrobenzoate + NADH + H+
-
about 30% activity compared to succinate semialdehyde
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
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2.3% of the activity with succinate semialdehyde
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
about 5% activity compared to succinate semialdehyde
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
-
about 10% activity compared to succinate semialdehyde
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-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
about 5% activity compared to succinate semialdehyde
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
about 30% activity compared to succinate semialdehyde
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-
?
glutarate + NADH
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13% of the activity with succinate semialdehyde
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-
?
glutaric semialdehyde + NAD+ + H2O
glutarate + NADH
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25% of the activity with succinate semialdehyde
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-
?
3-(methoxycarbonyl)benzoate + NADH + H+
about 20% activity compared to succinate semialdehyde
-
-
?
methyl 3-formylbenzoate + NAD+ + H2O
3-(methoxycarbonyl)benzoate + NADH + H+
-
about 45% activity compared to succinate semialdehyde
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-
?
4-(methoxycarbonyl)benzoate + NADH + H+
about 15% activity compared to succinate semialdehyde
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-
?
methyl 4-formylbenzoate + NAD+ + H2O
4-(methoxycarbonyl)benzoate + NADH + H+
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about 30% activity compared to succinate semialdehyde
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-
?
n-butanal + NAD+ + H2O
butanoate + NADH + H+
about 10% activity compared to succinate semialdehyde
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-
?
n-butanal + NAD+ + H2O
butanoate + NADH + H+
-
less than 60% activity compared to succinate semialdehyde
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-
?
n-hexanal + NAD+ + H2O
hexanoate + NADH + H+
less than 10% activity compared to succinate semialdehyde
-
-
?
n-hexanal + NAD+ + H2O
hexanoate + NADH + H+
-
about 110% activity compared to succinate semialdehyde
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-
?
n-octanal + NAD+ + H2O
n-octanoate + NADH + H+
less than 10% activity compared to succinate semialdehyde
-
-
?
n-octanal + NAD+ + H2O
n-octanoate + NADH + H+
-
less than 80% activity compared to succinate semialdehyde
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-
?
n-pentanal + NAD+ + H2O
n-pentanoate + NADH + H+
less than 20% activity compared to succinate semialdehyde
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-
?
n-pentanal + NAD+ + H2O
n-pentanoate + NADH + H+
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100% activity
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-
?
p-nitrobenzoate + NADH
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6.5% of the activity with succinate semialdehyde
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-
?
propanoate + NADH + H+
less than 10% activity compared to succinate semialdehyde
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-
?
propanal + NAD+ + H2O
propanoate + NADH + H+
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less than 20% activity compared to succinate semialdehyde
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?
propionate + NADH
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5% of the activity with succinate semialdehyde
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?
succinate + NAD(P)H + H+
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?
succinate semialdehyde + NAD(P)+ + H2O
succinate + NAD(P)H + H+
cysteine 311 and glutamic acid 277 are likely candidates for the active site residues directly involved in catalysis
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?
succinate semialdehyde + NAD(P)+ + H2O
succinate + NAD(P)H + H+
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-
-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme is induced by growth on gamma-aminobutyrate
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-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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-
-
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
last enzyme in catabolism of 4-aminobutyric acid. Human SSADH deficiency results in 4-hydroxybutyric aciduria, an autosomal recessive disorder due to an accumulation of 4-aminobutyric acid and 4-hydroxybutyric acid in the CNS
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ir
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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-
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-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme of agmatine degradation
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme is induced by growth on gamma-aminobutyrate
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme is induced by succinate semialdehyde, functions in the oxidation of succinate semialdehyde during growth on both 4-hydroxyphenylacetate and 4-aminobutyrate
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme is induced by succinate semialdehyde, functions in the oxidation of succinate semialdehyde during growth on both 4-hydroxyphenylacetate and 4-aminobutyrate
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme may play an important role, not only in metabolizing succinate semialdehyde but also in oxidation of aromatic aldehydes in the soil environment
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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induced by pyridine, the enzyme is involved in the degradation of pyridine
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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reverse reaction proceeds at 1/1230 of the rate of the forward eaction
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ir
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme is involved in the catabolism of the neurotransmitter 4-aminobutyrate
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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ir
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
the enzyme is specific for the substrates
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
the enzyme is specific for the substrates
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-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
-
-
-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
-
-
-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
no activity in presence of NADP+
-
-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + H+
-
enzyme of the gamma-aminobutyrate shunt required to restrict levels of reactive oxygen intermediates in plants
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + H+
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-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + H+
-
-
-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + H+
100% activity with succinate semialdehyde
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-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + H+
-
-
-
-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + H+
-
100% activity with succinate semialdehyde
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?
succinate + NADPH
-
20% of the activity with NAD+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH
-
reduction rate is only a few percent of that of NAD+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH
-
activity with NAD+ is 10times higher than with NADP+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH
-
activity with NAD+ is 10times higher than with NADP+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH
-
reaction with NADP+ is 13% of the activity with NAD+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH
-
activity with NAD+ is about 7fold higher than activity with NADP+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH
-
activity with NAD+ is about 7fold higher than activity with NADP+
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ir
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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-
-
-
?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
NAD+ is the more efficient coenzyme compared to NADP+, but the preference is not exclusive
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?
?
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no activity with formaldehyde, o-nitrobenzaldehyde, o-carboxybenzaldehyde, o-tolualdehyde, p-tolualdehyde, o-methoxybenzaldehyde, p-methoxybenzaldehyde o-hydroxybenzaldehyde, m-hydroxybenzaldehyde, phenylacetaldehyde and glyoxylic acid
-
-
?
additional information
?
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no substrate: formaldehyde, acetaldehyde, glyoxal, glyoxalate, propanal, glutaraldehyde, benzaldehyde, and anisaldehyde
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?
additional information
?
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no substrate: glyoxylic acid, formic acid, formaldehyde, acetaldehyde, glyoxal, furfural and acrolein
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?
additional information
?
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deficiency of succinate semialdehyde dehydrogenase is a rare autosomal recessively inherited metabolic disorder that results in acumulation of 4-hydroxybutyrate. Functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency
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?
additional information
?
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ALDH5A1 plays an important role as a gamma-aminobutyric acid catabolic enzyme and potentially as a detoxifying enzyme involved in aldehyde scavenging
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?
additional information
?
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no activity towards 2-methoxybenzaldehyde, and 4-tolualdehyde
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?
additional information
?
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no activity towards 2-methoxybenzaldehyde, 2-nitrobenzaldehyde, 2-carboxybenzaldehyde, 2-tolualdehyde, 4-tolualdehyde, 2-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, 2-phenylacetaldedyde, and glyoxylic acid
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?
additional information
?
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formaldehyde, betaine aldehyde and benzaldehyde can not serve as substrates
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?
additional information
?
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formaldehyde, betaine aldehyde and benzaldehyde can not serve as substrates
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?