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1.2.1.24: succinate-semialdehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.2.1.24

Reaction

succinate semialdehyde
+
NAD+
+
H2O
=
succinate
+
NADH
+
H+

Synonyms

aldehyde dehydrogenase 5a1, ALDH5A, ALDH5A1, alphaKGSA dehydrogenase, dehydrogenase, succinate semialdehyde, NAD(+)-dependent succinic semialdehyde dehydrogenase, SSADH, SSADH-I, SSADH/ALDH5A1, SSALDH, SSO1629, succinate semialdehyde dehydrogenase, succinate semialdehyde:NAD+ oxidoreductase, succinic semialdehyde dehydrogenase, succinyl semialdehyde dehydrogenase, YneI dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)

Substrates Products

Substrates Products on EC 1.2.1.24 - succinate-semialdehyde dehydrogenase (NAD+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,5-dioxopentanoate + NAD+ + H2O
?
show the reaction diagram
no activity in presence of NADP+
-
-
?
2-carboxybenzaldehyde + NAD+ + H2O
2-carboxybenzoate + NADH + H+
show the reaction diagram
about 1% activity compared to succinate semialdehyde
-
-
?
2-hydroxybenzaldehyde + NAD+ + H2O
2-hydroxybenzoate + NADH + H+
show the reaction diagram
about 1% activity compared to succinate semialdehyde
-
-
?
2-nitrobenzaldehyde + NAD+ + H2O
2-nitrobenzoate + NADH + H+
show the reaction diagram
about 3% activity compared to succinate semialdehyde
-
-
?
2-phenylacetaldehyde + NAD+ + H2O
2-phenylbenzoate + NADH + H+
show the reaction diagram
about 5% activity compared to succinate semialdehyde
-
-
?
2-tolualdehyde + NAD+ + H2O
2-carboxytoluene + NADH + H+
show the reaction diagram
about 1% activity compared to succinate semialdehyde
-
-
?
3-aminopropanal + NAD+ + H2O
3-aminopropanoate + NADH + H+
show the reaction diagram
-
low activity
-
-
?
3-carboxybenzaldehyde + NAD(P)+ + H2O
3-carboxybenzoate + NAD(P)H + H+
show the reaction diagram
3-carboxybenzaldehyde + NAD+ + H2O
3-carboxybenzoate + NADH + H+
show the reaction diagram
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
show the reaction diagram
3-methoxy-benzaldehyde + NAD+ + H2O
3-methoxy-benzoate + NADH + H+
show the reaction diagram
3-methylbenzaldehyde + NAD+ + H2O
3-methylbenzoate + NADH + H+
show the reaction diagram
3-nitrobenzaldehyde + NAD+ + H2O
3-nitrobenzoate + NADH + H+
show the reaction diagram
4-aminobutanal + NAD+ + H2O
4-aminobutanoate + NADH
show the reaction diagram
-
low activity
-
-
?
4-carboxybenzaldehyde + NAD(P)+ + H2O
4-carboxybenzoate + NAD(P)H + H+
show the reaction diagram
4-carboxybenzaldehyde + NAD+ + H2O
4-carboxybenzoate + NADH + H+
show the reaction diagram
4-hydroxy-trans-2-nonenal + NAD+
?
show the reaction diagram
-
elevated levels of 4-hydroxy-trans-2-nonenal are implicated in the pathogenesis of numerous neurodegenerative disorders. Succinate-semialdehyde dehydrogenase is the predominant oxidizing enzyme for 4-hydroxy-trans-2-nonenal but only contributes a portion of the total oxidizing activity in liver mitochondria
-
-
?
4-hydroxy-trans-2-nonenal + NAD+ + H2O
4-hydroxy-trans-2-nonenoate + NADH + H+
show the reaction diagram
4-methoxy-benzaldehyde + NAD+ + H2O
4-methoxy-benzoate + NADH + H+
show the reaction diagram
4-nitrobenzaldehyde + NAD+ + H2O
4-nitrobenzoate + NADH + H+
show the reaction diagram
acetaldehyde + NAD(P)+ + H2O
acetate + NAD(P)H + H+
show the reaction diagram
-
-
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
show the reaction diagram
alpha-ketoglutaric semialdehyde + NAD+ + H2O
alpha-ketoglutarate + NADH
show the reaction diagram
-
-
-
?
alpha-ketoglutaric semialdehyde + NADP+ + H2O
alpha-ketoglutarate + NADPH
show the reaction diagram
-
-
-
?
benzaldehyde + NAD(P)+ + H2O
benzoate + NAD(P)H + H+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
show the reaction diagram
betaine aldehyde + NAD+ + H2O
2-trimethylammonioacetate + NADH
show the reaction diagram
-
-
-
?
butanal + NAD(P)+ + H2O
butanoate + NAD(P)H + H+
show the reaction diagram
-
-
-
-
?
butanaldehyde + NAD+ + H2O
butanoate + NADH
show the reaction diagram
-
-
-
?
formaldehyde + NAD+ + H2O
formate + NADH
show the reaction diagram
-
-
-
?
glutaraldehyde + NAD+ + H2O
glutarate + NADH
show the reaction diagram
-
-
-
?
glutaric semialdehyde + NAD+ + H2O
glutarate + NADH
show the reaction diagram
glyceraldehyde + NAD+ + H2O
glycerate + NADH
show the reaction diagram
-
-
-
?
glycoaldehyde + NAD+ + H2O
glycolate + NADH
show the reaction diagram
-
-
-
?
glyoxylic acid + NAD+ + H2O
2-phenylbenzoate + NADH + H+
show the reaction diagram
about 1% activity compared to succinate semialdehyde
-
-
?
heptanaldehyde + NAD+ + H2O
heptanoate + NADH
show the reaction diagram
-
-
-
?
hexanaldehyde + NAD+ + H2O
hexanoate + NADH
show the reaction diagram
-
-
-
?
iso-butanal + NAD+ + H2O
? + NADH + H+
show the reaction diagram
less than 10% activity compared to succinate semialdehyde
-
-
?
iso-butanal + NAD+ + H2O
isobutanoate + NADH + H+
show the reaction diagram
-
less than 10% activity compared to succinate semialdehyde
-
-
?
iso-pentanal + NAD+ + H2O
? + NADH + H+
show the reaction diagram
about 2% activity compared to succinate semialdehyde
-
-
?
iso-pentanal + NAD+ + H2O
isopentanoate + NADH + H+
show the reaction diagram
-
less than 5% activity compared to succinate semialdehyde
-
-
?
isobutyraldehyde + NAD+ + H2O
isobutyrate + NADH + H+
show the reaction diagram
-
-
-
?
m-carboxybenzaldehyde + NAD+ + H2O
m-carboxybenzoate + NADH + H+
show the reaction diagram
-
-
-
?
m-methylcarboxybenzaldehyde + NAD+ + H2O
m-methylcarboxybenzoate + NADH + H+
show the reaction diagram
-
-
-
?
m-nitrobenzaldehyde + NAD+ + H2O
m-nitrobenzoate + NADH
show the reaction diagram
-
4.3% of the activity with succinate semialdehyde
-
-
?
malonate semialdehyde + NAD+ + H2O
malonate + NADH + 2 H+
show the reaction diagram
-
3.8% of the activity with succinate semialdehyde
-
-
?
methyl 3-formylbenzoate + NAD+ + H2O
3-(methoxycarbonyl)benzoate + NADH + H+
show the reaction diagram
methyl 4-formylbenzoate + NAD+ + H2O
4-(methoxycarbonyl)benzoate + NADH + H+
show the reaction diagram
n-butanal + NAD+ + H2O
butanoate + NADH + H+
show the reaction diagram
n-butanal + NAD+ + H2O
butanoic acid + NADH + 2 H+
show the reaction diagram
-
about 11% of the rate with succinic semialdehyde
-
-
?
n-hexanal + NAD+ + H2O
hexanoate + NADH + H+
show the reaction diagram
n-octanal + NAD+ + H2O
n-octanoate + NADH + H+
show the reaction diagram
n-pentanal + NAD+ + H2O
n-pentanoate + NADH + H+
show the reaction diagram
octanaldehyde + NAD+ + H2O
octanoate + NADH
show the reaction diagram
-
-
-
?
p-nitrobenzaldehyde + NAD+ + H2O
p-nitrobenzoate + NADH
show the reaction diagram
pentanal + NAD(P)+ + H2O
pentanoate + NAD(P)H + H+
show the reaction diagram
pentanaldehyde + NAD+ + H2O
pentanoate + NADH
show the reaction diagram
-
-
-
?
propanal + NAD(P)+ + H2O
propanoate + NAD(P)H + H+
show the reaction diagram
-
-
-
-
?
propanal + NAD+ + H2O
propanoate + NADH + H+
show the reaction diagram
propanaldehyde + NAD+ + H2O
propanoate + NADH
show the reaction diagram
-
-
-
?
propionaldehyde + NAD+ + H2O
propionate + NADH
show the reaction diagram
succinate semialdehyde + 3-acetylpyridine adenine dinucleotide + H2O
succinate + reduced 3-acetylpyridine adenine dinucleotide + H+
show the reaction diagram
-
-
-
-
r
succinate semialdehyde + NAD(P)+ + H2O
succinate + NAD(P)H + H+
show the reaction diagram
succinate semialdehyde + NAD+
succinate + NADH + H+
show the reaction diagram
-
-
-
-
?
succinate semialdehyde + NAD+ + H2O
succinate + NADH
show the reaction diagram
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
show the reaction diagram
succinate semialdehyde + NAD+ + H2O
succinate + NADH + H+
show the reaction diagram
succinate semialdehyde + NADP+ + H2O
succinate + NADPH
show the reaction diagram
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
show the reaction diagram
trans-2-hexenal + NAD+ + H2O
trans-2-hexenoate + NADH + H+
show the reaction diagram
-
-
-
-
?
additional information
?
-