1.2.1.24: succinate-semialdehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.2.1.24

1.2.1.24

aldhs

gamma-hydroxybutyric

ssadhd

4-hydroxybutyric

propionaldehyde

trans-4-hydroxy-2-nonenal

aldh4a1

akr7a2

ssadh-deficient

medicine

Reaction

Synonyms

aldehyde dehydrogenase 5a1, ALDH5A, ALDH5A1, alphaKGSA dehydrogenase, dehydrogenase, succinate semialdehyde, NAD(+)-dependent succinic semialdehyde dehydrogenase, SSADH, SSADH-I, SSADH/ALDH5A1, SSALDH, SSO1629, succinate semialdehyde dehydrogenase, succinate semialdehyde:NAD+ oxidoreductase, succinic semialdehyde dehydrogenase, succinyl semialdehyde dehydrogenase, YneI dehydrogenase

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)

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Results	in table
11	Activating Compound
2490	AA Sequence
8	Application
1	CAS Registry Number
19	Cloned(Commentary)
76	Cofactor
2	Crystallization (Commentary)
122	Disease/ Diagnostics
2	Expression
15	General Information
3	General Stability
6	IC50 Value
103	Inhibitors
3	kcat/KM [mM/s]
10	Ki Value [mM]
119	KM Value [mM]
15	Localization
1	Metals/Ions
42	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
124	Organism
2	Oxidation Stability
11	Pathway
9	PDB ID
20	pH Optimum
9	pH Range
5	pH Stability
1	pI Value
67	Protein Variants
20	Purification (Commentary)
5	Reaction
3	Reaction Type
82	Reference
63	Source Tissue
12	Specific Activity [micromol/min/mg]
8	Storage Stability
197	Substrates and Products (Substrate)
24	Subunits
110	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
6	Temperature Stability [°C]
7	Turnover Number [1/s]

Cloned

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Cloned on EC 1.2.1.24 - succinate-semialdehyde dehydrogenase (NAD+)

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4 entries

expressed in Escherichia coli M15 cells

2 entries

expressed in Escherichia coli Rosetta 2 (DE3) cells

Rattus norvegicus

697282

expression in Escherichia coli

Saccharolobus solfataricus

Q97XS9

722211

expression in Escherichia coli as His-tag fusion protein

2 entries

expression of mutant enzymes is expressed after transfection of HEK293 cells

Homo sapiens

P51649

655701

gene ALDH5A1 gene, located in the 6p22.3 region, genotyping, recombinant epression of wild-type and mutant enzymes in HEK-293 cells, quantitative RT-PCR expression analysis

Homo sapiens

P51649

763472

gene ALDH5A1, screening and genotyping, DNA and amino acid sequence determination and analysis

Homo sapiens

P51649

741570

into vectors pQE30 and into pMalc2x. Expression in Escherichia coli strains M15 and TB1

2 entries

overexpressed as His-tagged YneI

Escherichia coli

692836

PCR product cloned into pCR2.1-Topo. Open reading frame ligated into vector QE30. Overexpressed in Escherichia coli M15. Subcloned into pMALc2x and expressed in Escherichia coli TB1

Drosophila melanogaster

Q9VBP6

692615

transfection of HEK 293 cells

Homo sapiens

Q8N3W7

656808