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1.2.1.21: glycolaldehyde dehydrogenase

This is an abbreviated version!
For detailed information about glycolaldehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.21

Reaction

glycolaldehyde
+
NAD+
 +
H2O
=
glycolate
 +
NADH
 +
H+

Synonyms

ALDH, ALDH3I1, ALDH7B4, dehydrogenase, glycol aldehyde

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.21 glycolaldehyde dehydrogenase

Inhibitors

Inhibitors on EC 1.2.1.21 - glycolaldehyde dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Al3+
-
1 mM, isozyme A, 26% inhibition
As3+
-
1 mM, isozyme A, 42% inhibition, isozyme B, 11% inhibition, isozyme C, 55% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3
Ca2+
-
1 mM, isozyme A, 42% inhibition, isozyme B, 32% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3
Co2+
-
1 mM, isozyme A, 71% inhibition, isozyme B, 51% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3
glycolaldehyde
-
substrate inhibition
glycolate
-
substrate inhibition
HgCl2
KCN
-
isozymes A and C
Mg2+
-
1 mM, isozyme A, 33% inhibition, isozyme B, 54% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3
Mn2+
-
1 mM, isozyme A, 20% inhibition, isozyme C, 44% inhibition
monoiodoacetate
-
1 mM, isozymes A, 83% inhibition, isozyme C, 100% inhibition
MoO22-
-
1 mM, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3
p-chloromercuribenzoate
-
0.1 mM, 36% inhibition
pyridoxal
-
0.01 mM, 40% inhibition of total enzyme activity in cell extracts
pyridoxamine
-
approx. 0.1 mM, 22% inhibition of isozyme A
pyridoxamine phosphate
-
approx. 0.1 mM, 23% inhibition of isozyme A
pyridoxine
-
approx. 0.1 mM, 33% inhibition of isozyme C, 0.39 mM, 50% inhibition
pyridoxine phosphate
-
approx. 0.1 mM, 23% inhibition of isozyme C
Zn2+
-
1 mM, isozyme A, 30% inhibition