1.2.1.19: aminobutyraldehyde dehydrogenase

This is an abbreviated version!
For detailed information about aminobutyraldehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

4-aminobutanal dehydrogenase, 4-aminobutyraldehyde dehydrogenase, ABAL dehydrogenase, ABALDH, ALDH10A8, ALDH10A9, AMADH, AMADH1, AMADH2, aminoaldehyde dehydrogenase, BADH, betaine aldehyde dehydrogenase, dehydrogenase, aminobutyraldehyde, EC 1.5.1.35, gadbh, gamma-aminobutanal dehydrogenase, gamma-aminobutyraldehyde dehydroganase, gamma-aminobutyraldehyde dehydrogenase, gamma-guanidinobutyraldehyde dehydrogenase, MdAMADH1, MdAMADH2, More, NAD+-aminoaldehyde dehydrogenase, NAD+-dependent aminoaldehyde dehydrogenase, PatD, PsAMADH 1, PsAMADH 2, SlAMADH1, SlAMADH2, YdcW, ZmAMADH1a, ZmAMADH1b, ZmAMADH2

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.19 aminobutyraldehyde dehydrogenase

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Results	in table
2	Activating Compound
3602	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
42	Cofactor
4	Crystallization (Commentary)
25	Disease/ Diagnostics
7	Expression
22	General Information
3	General Stability
36	Inhibitors
37	kcat/KM [mM/s]
7	Ki Value [mM]
150	KM Value [mM]
19	Localization
4	Metals/Ions
19	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
63	Organism
12	Pathway
62	PDB ID
26	pH Optimum
10	pH Range
1	pH Stability
2	pI Value
4	Protein Variants
19	Purification (Commentary)
2	Reaction
3	Reaction Type
49	Reference
41	Source Tissue
38	Specific Activity [micromol/min/mg]
5	Storage Stability
199	Substrates and Products (Substrate)
18	Subunits
83	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
23	Temperature Stability [°C]
69	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 1.2.1.19 - aminobutyraldehyde dehydrogenase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

-15

Pseudomonas fluorescens

-

retains 70% of activity when stored for 2 weeks

288041

-20

Rattus norvegicus

-

stable over several months

288064

0 - 35

Escherichia coli

-

up to 5 min, stable

288063

2

Pseudomonas fluorescens

-

80% loss of activity after overnight storage

288041, 288066

28

Rattus norvegicus

-

temperature higher than 28°C promotes slow activation

288081

30

4 entries

35

Escherichia coli

-

unstable above

288063

40

Arthrobacter sp.

-

64% loss of activity after 10 min

655946

50

3 entries

50 - 60

Glycine max

U5ILS4

purified enzyme, pH 8.0, rapid inactivation above 50°C, loss of almost 50% activity at 60°C

742430

60

5 entries

70

2 entries

30

Pseudomonas putida

-

30 min, pH 5.0-8.0, stable

288069

30

Pseudomonas putida

-

for 30 min, in 100 mM Na-acetate buffer, pH 5, allmost all activity retained

288069

30

Pseudomonas putida

-

for 30 min, in 100 mM K-phosphate buffer, pH 7, allmost all activity retained

288069

30

Pseudomonas putida

-

for 30 min, in 100 mM Na-bicine buffer, pH 8, allmost all activity retained

288069

50

Pseudomonas aeruginosa

-

for 5 min, thermal denaturation of both 4-aminobutyraldehyde dehydrogenase and 4-guanidinobutyraldehyde dehydrogenase activities observed

2168

50

Pseudomonas fluorescens

-

for 5 min, 63% activity recovered

288066

50

Pseudomonas fluorescens

-

for 5 min, NAD+ present during heating, 100% activity recovered

288066

60

Pseudomonas aeruginosa

-

for 5 min, thermal denaturation of both 4-aminobutyraldehyde dehydrogenase and 4-guanidinobutyraldehyde dehydrogenase activities observed

2168

60

Pseudomonas fluorescens

-

for 5 min, 33% activity recovered

288066

60

Pseudomonas fluorescens

-

for 5 min, NAD+ present during heating, 53% activity recovered

288066

60

Pseudomonas putida

-

pH 7.0, 15 min, 35% loss of activity

288069

60

Pseudomonas putida

-

for 15 min, in 100 mM K-phosphate buffer, pH 7, 35% of activity lost

288069

70

Pseudomonas fluorescens

-

for 5 min, 3% activity recovered

288066

70

Pseudomonas fluorescens

-

for 5 min, NAD+ present during heating, 16% activity recovered

288066