1.2.1.16: succinate-semialdehyde dehydrogenase [NAD(P)+]

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For detailed information about succinate-semialdehyde dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

Synonyms

3-sulfopropanal dehydrogenase, ALDH, BADH, BsSSADH, cce4228, cce4228 protein, dehydrogenase, succinate semialdehyde (nicotinamide adenine dinucleotide (phosphate)), gabD, GabD dehydrogenase, GabD1, gapN-2, More, NAD(P)+-coupled 3-sulfopropanal dehydrogenase, NAD(P)+-dependent benzaldehyde dehydrogenase, NAD(P)+-dependent succinate semialdehyde dehydrogenase, NAD(P)+-dependent succinic semialdehyde dehydrogenase, NAD(P)-dependent benzaldehyde dehydrogenase, NAD+/NADP+-dependent benzaldehyde dehydrogenase, NAD+/NADP+-dependent SSADH, SpSSADH, SSA dehydrogenase, SSADH, SSADH-II, SSADHase, SSDH, SSO1842, ST0064, succinate semialdehyde dehydrogenase, succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate)), succinate-semialdehyde dehydrogenase, succinate-semialdehyde dehydrogenase (NAD(P)), succinate-semialdehyde dehydrogenase (NAD(P)+), succinic semialdehyde dehydrogenase, succinic semialdehyde:NAD(P)+ oxidoreductase, sulfopropanal dehydrogenase, YneI

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]

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Results	in table
18	Activating Compound
9051	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
64	Cofactor
4	Crystallization (Commentary)
3	Expression
13	General Information
4	General Stability
31	Inhibitors
80	kcat/KM [mM/s]
9	Ki Value [mM]
123	KM Value [mM]
8	Localization
9	Metals/Ions
21	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
681	Organism
1	Oxidation Stability
9	Pathway
47	PDB ID
16	pH Optimum
8	pH Range
4	pH Stability
48	Protein Variants
21	Purification (Commentary)
4	Reaction
4	Reaction Type
52	Reference
6	Source Tissue
78	Specific Activity [micromol/min/mg]
5	Storage Stability
147	Substrates and Products (Substrate)
18	Subunits
82	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
5	Temperature Stability [°C]
91	Turnover Number [1/s]

General Stability

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General Stability on EC 1.2.1.16 - succinate-semialdehyde dehydrogenase [NAD(P)+]

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

dithiothreitol is necessary both to maintain the activity of BADH and to prevent oligimerization of the enzyme

Pseudomonas putida

-

685387

enzyme is labile (50% loss of activity overnight) but can be largely stabilized (in crude extract only) by the addition of 10 mM dithiothreitol 1.2.1.16

Cupriavidus necator

Q0K2K1

698627

ethyleneglycol, 30%, stabilizes

Euglena gracilis

-

288042

glycerol, 30%, stabilizes

Euglena gracilis

-

288042