1.2.1.105: 2-oxoglutarate dehydrogenase system
This is an abbreviated version!
For detailed information about 2-oxoglutarate dehydrogenase system, go to the full flat file.
Word Map on EC 1.2.1.105
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1.2.1.105
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kgdhc
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dihydrolipoamide
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thiamin
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alpha-ketoacids
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2-oxoadipate
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transsuccinylase
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charcot-marie-tooth
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2-aminoadipic
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medicine
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thiokinase
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glutaryl-coa
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analysis
- 1.2.1.105
- kgdhc
- dihydrolipoamide
- thiamin
- alpha-ketoacids
- 2-oxoadipate
-
transsuccinylase
- charcot-marie-tooth
-
2-aminoadipic
- medicine
- thiokinase
- glutaryl-coa
- analysis
Reaction
Synonyms
2-OGDH2, 2-oxoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase complex, alpha-KDE2, alpha-ketoglutarate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, alpha-KGDH, At3g55410, At5g65750, DHTKD1, dihydrolipoyl succinyltransferase E2, E1a, E1k, E1o, E2, KGDH, KGDHC, More, MPA24.10, ODGH, ODGH1, ODGH2, ODH, OGDC, OGDH, OGDHC, OGDHL, OGHDC-E2, PDHC, SucA, SucB
ECTree
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Cofactor
Cofactor on EC 1.2.1.105 - 2-oxoglutarate dehydrogenase system
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3-acetylpyridine adenine dinucleotide
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3-acetylpyridine adenine dinucleotide can be used instead of NAD+ to avoid concomitant oxidase activity that would degrade NADH produced by the ODH reaction
lipoic acid
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leads to a stabilization of cognitive functions in Alzheimer's disease patients
thiamine diphosphate
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required , 2-oxoglutarate dehydrogenase complex
thiamine diphosphate
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required , 2-oxoglutarate dehydrogenase complex
thiamine diphosphate
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required , 2-oxoglutarate dehydrogenase complex
thiamine diphosphate
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2-oxoglotarate dehydrogenase component of the 2-oxoglutarate dehydrogenase complex is dependent on thiamine diphosphate. Thiamine diphosphate attacks the alpha-carbon of 2-oxoglutarate and decarboxylates the substrate. The thiamine diphosphate reaction adduct then reductively acylates the lipoyl moiety of EC 2.3.1.61
thiamine diphosphate
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thiamine diphosphate is tightly but not covalently bound to the 2-oxoglutarate dehydrogenase component
thiamine diphosphate
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2-oxoglutarate dehydrogenase complex contains thiamine diphosphate
thiamine diphosphate
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formation of a precatalytic complex SE between the substrate and the 2-oxoglutarate dehydrogenase component before the catalytic complex ES, in which the substrate is added to the thiamin diphosphate cofactor
thiamine diphosphate
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activates the 2-oxoglutarate dehydrogenase complex activity, involved in conformational changes
thiamine diphosphate
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thiamine deficiency results in decreased enzyme complex activity and selective neuronal loss
additional information
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2-oxoglutarate dehydrogenase complex contains protein-bound lipoic acid
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additional information
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EC 1.8.1.4, dihydrolipoyl dehydrogenase component of the 2-oxoglutarate dehydrogenase complex is a flavin protein
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additional information
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the complex contains 12.1 mol FAD per mol of enzyme complex
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additional information
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EC 2.3.1.61, dihydrolipoamide succinyltransferase component of the 2-oxoglutarate dehydrogenase enzyme complex contains a lipoate moiety that is covalently bound to Lys110 through an epsilon-amide linkage. The thiamine diphosphate reaction adduct then reductively acylates the lipoyl moiety of EC 2.3.1.61
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additional information
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lipoyl moiety, LipS2, is bound in amide linkage to the epsilon amino group of a lysine residue
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