1.2.1.105: 2-oxoglutarate dehydrogenase system

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For detailed information about 2-oxoglutarate dehydrogenase system, go to the full flat file.

Word Map on EC 1.2.1.105

1.2.1.105

kgdhc

dihydrolipoamide

thiamin

alpha-ketoacids

2-oxoadipate

transsuccinylase

charcot-marie-tooth

2-aminoadipic

medicine

thiokinase

glutaryl-coa

analysis

Reaction

Synonyms

2-OGDH2, 2-oxoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase complex, alpha-KDE2, alpha-ketoglutarate dehydrogenase, alpha-ketoglutarate dehydrogenase complex, alpha-KGDH, At3g55410, At5g65750, DHTKD1, dihydrolipoyl succinyltransferase E2, E1a, E1k, E1o, E2, KGDH, KGDHC, More, MPA24.10, ODGH, ODGH1, ODGH2, ODH, OGDC, OGDH, OGDHC, OGDHL, OGHDC-E2, PDHC, SucA, SucB

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.105 2-oxoglutarate dehydrogenase system

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Results	in table
36	Activating Compound
7	AA Sequence
15	Application
7	Cloned(Commentary)
56	Cofactor
3	Crystallization (Commentary)
17	General Information
4	General Stability
5	IC50 Value
133	Inhibitors
19	kcat/KM [mM/s]
13	Ki Value [mM]
84	KM Value [mM]
53	Localization
30	Metals/Ions
14	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
132	Organism
9	Pathway
19	pH Optimum
6	pH Range
2	Posttranslational Modification
17	Protein Variants
18	Purification (Commentary)
69	Reaction
127	Reference
1	Renatured (Commentary)
110	Source Tissue
16	Specific Activity [micromol/min/mg]
1	Storage Stability
124	Substrates and Products (Substrate)
18	Subunits
143	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
17	Turnover Number [1/s]

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Cloned on EC 1.2.1.105 - 2-oxoglutarate dehydrogenase system

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assembly of the complex from the individually expressed components in vitro

Homo sapiens

A0A024R713; A0A024R6C9

758854

expressed in 293 T cells

Homo sapiens

763003

expressed in Corynebacterium glutamicum

Corynebacterium glutamicum

687856

expressed in PC-12 cells

Homo sapiens

656174

expression in Escherichia coli

2 entries

FLAG-tagged enzyme expression in siah2-/- cells and siah2+/+ cells in mitochondria and, by disruption of the mitochondrial targeting sequence, in cytoplasm, in the cytoplasm the enzyme is rapidly proteasome-dependently degraded, overvexpression of hemagglutinin-labeled enzyme E2 in 293T cells

Homo sapiens

656265