1.2.1.10: acetaldehyde dehydrogenase (acetylating)

This is an abbreviated version!
For detailed information about acetaldehyde dehydrogenase (acetylating), go to the full flat file.

Reaction

Synonyms

4-hydroxy-2-ketovalerate aldolase/acylating acetaldehyde dehydrogenase, ACDH, acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating], acetaldehyde-alcohol dehydrogenase, acetyl-CoA reductase, acylating acetaldehyde dehydrogenase, AdhE, ADHES77, aldehyde dehydrogenase, aldehyde dehydrogenase (acylating), aldehyde/alcohol dehydrogenase, ALDH, BAD, bi-functional alcohol/aldehyde dehydrogenase, bifunctional acetaldehyde-alcohol dehydrogenase, BphJ, CoA-acylating aldehyde dehydrogenase, CoA-dependent aldehyde dehydrogenase, coenzyme A linked aldehyde dehydrogenase, coenzyme A-acylating aldehyde dehydrogenase, DmpF, DmpFG, MhpF, More, NAD+/CoA-dependent aldehyde dehydrogenase, nonphosphorylating acylating aldehyde dehydrogenase, PduP, Teth514_0627, Teth514_1942, Tsac_0416, TTHB247

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.10 acetaldehyde dehydrogenase (acetylating)

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Results	in table
8	Activating Compound
8247	AA Sequence
9	Application
1	CAS Registry Number
18	Cloned(Commentary)
69	Cofactor
3	Crystallization (Commentary)
3	Expression
21	General Information
7	General Stability
25	Inhibitors
39	kcat/KM [mM/s]
4	Ki Value [mM]
94	KM Value [mM]
13	Localization
3	Metals/Ions
33	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
256	Organism
1	Oxidation Stability
31	Pathway
36	PDB ID
17	pH Optimum
10	pH Range
2	pH Stability
1	pI Value
16	Protein Variants
19	Purification (Commentary)
8	Reaction
4	Reaction Type
55	Reference
3	Source Tissue
31	Specific Activity [micromol/min/mg]
10	Storage Stability
151	Substrates and Products (Substrate)
29	Subunits
65	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
4	Temperature Range [°C]
8	Temperature Stability [°C]
26	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.2.1.10 - acetaldehyde dehydrogenase (acetylating)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

21 entries

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH + H+

4 entries

acetyl-CoA + NADH + H+

acetaldehyde + CoA + NAD+

3 entries

butanoyl-CoA + NADH + H+

butanal + CoA + NAD+

Aeromonas hydrophila

-

-

742372

-

-

r

formaldehyde + CoA + NAD+

formyl-CoA + NADH + H+

Acinetobacter sp. HBS-2

A5JT11

-

695594

-

-

?

propanal + CoA + NAD+

propionyl-CoA + NADH

3 entries

propanoyl-CoA + NADH + H+

propanal + CoA + NAD+

Aeromonas hydrophila

-

-

742372

-

-

r

propionaldehyde + CoA + NAD+

propionyl-CoA + NADH + H+

Acinetobacter sp. HBS-2

A5JT11

-

695594

-

-

?

additional information

?

-

5 entries

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Clostridium beijerinckii

-

-

390174

-

390174

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Clostridium beijerinckii NRRL B592

-

-

390174

-

390174

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Clostridium kluyveri

-

-

286052

-

286052

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Clostridium kluyveri

-

-

390168

-

390168

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Clostridium kluyveri

-

during ethanol fermentation

390170

-

390170

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Clostridium kluyveri

-

during ethanol fermentation

390176

-

390176

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Escherichia coli

-

-

390163

-

390163

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Escherichia coli

-

-

390171

-

390171

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Escherichia coli

-

-

390173

-

390173

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Escherichia coli

-

during glucose fermentation

390162

-

390162

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Escherichia coli

-

during glucose fermentation

390164

-

390164

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Escherichia coli B / ATCC 11303

-

during glucose fermentation

390164

-

390164

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Giardia intestinalis

-

-

390177

-

390177

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Giardia intestinalis WB / CC 30957

-

-

390177

-

390177

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Leuconostoc mesenteroides

-

ethanol production in aerobic glucose dissimilation

390167

-

390167

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Propionibacterium freudenreichii

-

-

390166

-

390166

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Pseudomonas sp.

-

-

390175

-

390175

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Pseudomonas sp.

-

involved in degradation of toxic aromatic compounds via the intermediate catechol

657161

-

-

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Pseudomonas sp. CF 600

-

-

390175

-

390175

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Pseudomonas sp. CF 600

-

involved in degradation of toxic aromatic compounds via the intermediate catechol

657161

-

-

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH

Thermoanaerobacter ethanolicus

-

-

286197

-

286197

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH + H+

Acinetobacter sp. HBS-2

A5JT11

-

695594

-

-

r

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH + H+

Citrobacter sp. S-77

-

-

742936

-

-

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH + H+

Escherichia coli

-

-

724721

-

-

?

acetaldehyde + CoA + NAD+

acetyl-CoA + NADH + H+

Paraburkholderia xenovorans

Q79AF6

-

724341

-

-

?

acetyl-CoA + NADH + H+

acetaldehyde + CoA + NAD+

Aeromonas hydrophila

-

best substrate

742372

-

-

r

acetyl-CoA + NADH + H+

acetaldehyde + CoA + NAD+

Chlamydomonas reinhardtii

Q1RS84

-

763253

-

-

r

acetyl-CoA + NADH + H+

acetaldehyde + CoA + NAD+

Escherichia coli

P0A9Q7

-

763497

-

-

r

propanal + CoA + NAD+

propionyl-CoA + NADH

Giardia intestinalis

-

is used 63% as efficiently as acetaldehyde

390177

-

390177

r

propanal + CoA + NAD+

propionyl-CoA + NADH

Giardia intestinalis WB / CC 30957

-

is used 63% as efficiently as acetaldehyde

390177

-

390177

r

propanal + CoA + NAD+

propionyl-CoA + NADH

Propionibacterium freudenreichii

-

fermentation of 1,2-propanediol

390166

-

390166

r

additional information

?

-

Chlamydomonas reinhardtii

Q1RS84

the bifunctional enzymes commonly produce ethanol from acetyl-CoA with acetaldehyde as intermediate

763253

-

-

-

additional information

?

-

Chlamydomonas reinhardtii CC-124

Q1RS84

the bifunctional enzymes commonly produce ethanol from acetyl-CoA with acetaldehyde as intermediate

763253

-

-

-

additional information

?

-

Escherichia coli

P0A9Q7

the bifunctional enzymes commonly produce ethanol from acetyl-CoA with acetaldehyde as intermediate

763497

-

-

-

additional information

?

-

Pseudomonas sp.

Q52060

DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview

727173

-

-

?

additional information

?

-

Pseudomonas sp. CF 600

Q52060

DmpFG is a bifunctional enzyme comprised of an aldolase subunit, DmpG, and a dehydrogenase subunit, DmpF. The aldehyde intermediate produced by the aldolase is channeled directly through a buried molecular channel in the protein structure from the aldolase to the dehydrogenase active site. Binding and channeling of alternative substrates in the enzyme DmpFG, molecular dynamics, overview

727173

-

-

?