1.14.20.4: anthocyanidin synthase

This is an abbreviated version!
For detailed information about anthocyanidin synthase, go to the full flat file.

Word Map on EC 1.14.20.4

Reaction

a (2R,3S,4S)-leucoanthocyanidin
+
2-oxoglutarate
+
O2
=
an anthocyanidin
+
succinate
+
CO2
+ 2 H2O

Synonyms

anthocyanidin synthase, anthocyanin synthase, leucocyanidin dioxygenase, ANS, leucoanthocyanidin dioxygenase, LDOX, leucoanthocyanidin oxygenase, GbANS, MdANS, IbANS, anthocyanidine synthase, leucocyanidin oxygenase, leucocyanidin,2-oxoglutarate:oxygen oxidoreductase, RtLDOX, McANS-1, anthocyanidin synthase 1, FcANS1, McANS-2, ANS-1, ANS-2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
                1.14.20.4 anthocyanidin synthase

Systematic Name

Systematic Name on EC 1.14.20.4 - anthocyanidin synthase

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SYSTEMATIC NAME
IUBMB Comments
(2R,3S,4S)-leucoanthocyanidin,2-oxoglutarate:oxygen oxidoreductase
The enzyme requires Fe(II) and ascorbate. It is involved in the pathway by which many flowering plants make anthocyanin flower pigments (glycosylated anthocyandins). The enzyme hydroxylates the C-3 carbon, followed by a trans diaxial elimination, forming a C-2,C-3 enol. The product loses a second water molecule to form anthocyanidins. When assayed in vitro, non-enzymic epimerization of the product can lead to formation of dihydroflavanols. Thus when the substrate is leucocyanidin, a mixture of (+)-taxifolin and (+)-epitaxifolin are formed. The enzyme can also oxidize the formed (+)-taxifolin to quercetin (cf. EC 1.14.20.6, flavonol synthase) [2,3].