1.14.20.4: anthocyanidin synthase

This is an abbreviated version!
For detailed information about anthocyanidin synthase, go to the full flat file.

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Synonyms

ANS, ANS-1, ANS-2, anthocyanidin synthase, anthocyanidin synthase 1, anthocyanidine synthase, anthocyanin synthase, FcANS1, GbANS, IbANS, LDOX, leucoanthocyanidin dioxygenase, leucoanthocyanidin oxygenase, leucocyanidin dioxygenase, leucocyanidin oxygenase, leucocyanidin,2-oxoglutarate:oxygen oxidoreductase, McANS-1, McANS-2, MdANS, RtLDOX

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated

                1.14.20.4 anthocyanidin synthase

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Results	in table
7	Activating Compound
126	AA Sequence
3	Application
1	CAS Registry Number
23	Cloned(Commentary)
3	Crystallization (Commentary)
9	Expression
21	General Information
3	KM Value [mM]
6	Localization
6	Metals/Ions
6	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
49	Organism
6	Pathway
5	pI Value
9	Protein Variants
9	Purification (Commentary)
5	Reaction
3	Reaction Type
46	Reference
56	Source Tissue
1	Specific Activity [micromol/min/mg]
34	Substrates and Products (Substrate)
5	Subunits
47	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.20.4 - anthocyanidin synthase

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SYSTEMATIC NAME

IUBMB Comments

(2R,3S,4S)-leucoanthocyanidin,2-oxoglutarate:oxygen oxidoreductase

The enzyme requires Fe(II) and ascorbate. It is involved in the pathway by which many flowering plants make anthocyanin flower pigments (glycosylated anthocyandins). The enzyme hydroxylates the C-3 carbon, followed by a trans diaxial elimination, forming a C-2,C-3 enol. The product loses a second water molecule to form anthocyanidins. When assayed in vitro, non-enzymic epimerization of the product can lead to formation of dihydroflavanols. Thus when the substrate is leucocyanidin, a mixture of (+)-taxifolin and (+)-epitaxifolin are formed. The enzyme can also oxidize the formed (+)-taxifolin to quercetin (cf. EC 1.14.20.6, flavonol synthase) [2,3].