1.14.19.8: pentalenolactone synthase
This is an abbreviated version!
For detailed information about pentalenolactone synthase, go to the full flat file.
Reaction
+ + 2 reduced ferredoxin + 2 H+ = + 2 oxidized ferredoxin + 2 H2O
Synonyms
CYP161C2, EC 1.3.7.10, penM, pntM
ECTree
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Substrates Products
Substrates Products on EC 1.14.19.8 - pentalenolactone synthase
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REACTION DIAGRAM
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+
pentalenolactone + 2 oxidized ferredoxin + 2 H2O
pentalenolactone + 2 oxidized ferredoxin + 2 H2O
-
-
-
-
ir
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+
pentalenolactone + 2 oxidized ferredoxin + 2 H2O
apparent ability of PntM to catalyze an exclusive carbocation-based oxidative rearrangement
-
-
?
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+
pentalenolactone + 2 oxidized ferredoxin + 2 H2O
-
-
-
-
ir
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+
pentalenolactone + 2 oxidized ferredoxin + 2 H2O
-
-
-
-
ir
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+
pentalenolactone + 2 oxidized ferredoxin + 2 H2O
-
-
-
-
ir
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+
pentalenolactone + 2 oxidized ferredoxin + 2 H2O
-
-
-
-
ir
pentalenolactone + NADP+ + H2O
-
-
-
-
?
pentalenolactone F + O2 + NADPH + H+
pentalenolactone + NADP+ + H2O
-
-
-
-
?
pentalenolactone F + O2 + NADPH + H+
pentalenolactone + NADP+ + H2O
-
-
-
-
?
pentalenolactone F + O2 + NADPH + H+
pentalenolactone + NADP+ + H2O
-
-
-
-
?
?
-
no activity with substrate analogue 6,7-dihydropentalenolactone, because the C1 carbocation is not anchimerically stabilized by the 6,7-double bond of pentalenolactone F. Enzyme-ligand interaction via three residues, F232, M77, and M81 that are unique to PntM and its orthologues and absent from essentially all other P450s
-
-
?
additional information
?
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-
no activity with substrate analogue 6,7-dihydropentalenolactone, because the C1 carbocation is not anchimerically stabilized by the 6,7-double bond of pentalenolactone F. Enzyme-ligand interaction via three residues, F232, M77, and M81 that are unique to PntM and its orthologues and absent from essentially all other P450s
-
-
?