1.14.19.6: acyl-CoA (9+3)-desaturase
This is an abbreviated version!
For detailed information about acyl-CoA (9+3)-desaturase, go to the full flat file.
Word Map on EC 1.14.19.6
-
1.14.19.6
-
linoleic
-
desaturation
-
oleic
-
polyunsaturated
-
synechocystis
-
alpha-linolenic
-
nutrition
- 1.14.19.6
-
linoleic
-
desaturation
-
oleic
-
polyunsaturated
- synechocystis
-
alpha-linolenic
- nutrition
Reaction
Synonyms
acyl-CoA (9+3)-desaturase, acyl-lipid DELTA12-desaturase, Cofad2-2, CSFAD2A, D12Des, DELTA 12 desaturase, delta 12 fatty acid desaturases, delta-12 fatty acid desaturase, delta-12 fatty acid desaturase 2, DELTA12 acyl-lipid desaturase, DELTA12 desaturase, DELTA12 FAD, DELTA12 fatty acid desaturase, DELTA12 oleate hydroxylase, DELTA12(omega6)-desaturase, DELTA12-acyl-lipid desaturase, DELTA12-desaturase, DELTA12-desaturase system, DELTA12-FAD, DELTA12-fatty acid desaturase, DELTA12-fatty acyl-CoA desaturase, DELTA12des, DELTA12DS, Des12, DesA, egFAD2, FAD-2, FAD2, FAD2-2, FAD2A, FADS1, FADS2, FAH, FAT-2, fatty acid desaturase-2, Fm2, KlFAD2, Le-FAD2, LKFAD15, microsomal Delta-12 fatty acid desaturase, microsomal delta-12 oleate desaturase, microsomal oleate desaturase, microsomal omega-6 fatty acid desaturase, oleoyl coenzyme A desaturase, oleoyl-CoA DELTA12 desaturase, oleoyl-DELTA12 desaturase, oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, omega-6 fatty acid desaturase, PtFAD2, PtFAD6, seed-specific delta-12 fatty acid desaturase 2
ECTree
1.14.19.6 acyl-CoA (9+3)-desaturaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.14.19.6 - acyl-CoA (9+3)-desaturase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(10Z)-nonadec-10-enoic acid + reduced acceptor + O2
(10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
5,8,11,14-eicosatetraenoyl-CoA + reduced acceptor + O2
5,8,11,14,17-eicosadecapentaenoyl-CoA + acceptor + H2O
6,9,12-octadecatrienoyl-CoA + reduced acceptor + O2
6,9,12,15-octadecatetraenoyl-CoA + acceptor + H2O
9,12-octadecadienoyl-CoA + reduced acceptor + O2
9,12,15-octadecatrienoyl-CoA + acceptor + H2O
9-hexadecenoyl-CoA + reduced acceptor + O2
9,12-hexadecadienoyl-CoA + acceptor + H2O
low activity
-
-
?
9-octadecenoyl-CoA + reduced acceptor + O2
9,12-octadecadienoyl-CoA + acceptor + H2O
-
-
-
?
acyl-CoA + reduced acceptor + O2
DELTA12-acyl-CoA + acceptor + H2O
-
-
-
?
cis-7-hexadecenoic acid + reduced acceptor + O2
cis,cis-7,10-hexadecadienoic acid + acceptor + H2O
-
5.2% desaturation
-
-
?
cis-9-heptadecenoic acid + reduced acceptor + O2
cis,cis-9,12-heptadecadienoic acid + acceptor + H2O
-
22.3% desaturation
-
-
?
cis-9-hexadecenoic acid + reduced acceptor + O2
cis,cis-9,12-hexadecadienoic acid + acceptor + H2O
cis-9-icosenoic acid + reduced acceptor + O2
cis,cis-11,14-icosadienoic acid + acceptor + H2O
-
4.1% desaturation
-
-
?
cis-9-octadecenoic acid + reduced acceptor + O2
cis,cis-9,12-octadecadienoic acid + acceptor + 2 H2O
eicosenoic acid + reduced acceptor + O2
20:2DELTA11,14 + acceptor + H2O
62% conversion
-
-
?
heptadecyloleic acid + reduced acceptor + O2
C17:2DELTA9,12 + acceptor + H2O
-
-
-
?
myristoleic acid + reduced acceptor + O2
C14:2DELTA9,12 + acceptor + H2O
-
-
-
?
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
palmitoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
(9Z,12Z)-hexadeca-9,12-dienoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
pentadecyloleic acid + reduced acceptor + O2
C15:2DELTA9,12 + acceptor + H2O + acceptor
-
-
-
?
(10Z)-nonadec-10-enoic acid + reduced acceptor + O2
(10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
-
-
-
-
?
(10Z)-nonadec-10-enoic acid + reduced acceptor + O2
(10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
-
-
-
-
?
(10Z)-nonadec-10-enoic acid + reduced acceptor + O2
(10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
-
-
-
-
?
(Z)-9-tetradecenoic acid + ?
tetradec-9,12-dienoic acid
-
biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a DELTA12 desaturase
-
-
?
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
-
?
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
5,8,11,14-eicosatetraenoyl-CoA + reduced acceptor + O2
5,8,11,14,17-eicosadecapentaenoyl-CoA + acceptor + H2O
-
-
-
?
5,8,11,14-eicosatetraenoyl-CoA + reduced acceptor + O2
5,8,11,14,17-eicosadecapentaenoyl-CoA + acceptor + H2O
-
-
-
?
6,9,12-octadecatrienoyl-CoA + reduced acceptor + O2
6,9,12,15-octadecatetraenoyl-CoA + acceptor + H2O
-
-
-
?
6,9,12-octadecatrienoyl-CoA + reduced acceptor + O2
6,9,12,15-octadecatetraenoyl-CoA + acceptor + H2O
-
-
-
?
9,12-octadecadienoyl-CoA + reduced acceptor + O2
9,12,15-octadecatrienoyl-CoA + acceptor + H2O
high activity
-
-
?
9,12-octadecadienoyl-CoA + reduced acceptor + O2
9,12,15-octadecatrienoyl-CoA + acceptor + H2O
high activity
-
-
?
cis-9-hexadecenoic acid + reduced acceptor + O2
cis,cis-9,12-hexadecadienoic acid + acceptor + H2O
-
14.7% desaturation
-
-
?
cis-9-hexadecenoic acid + reduced acceptor + O2
cis,cis-9,12-hexadecadienoic acid + acceptor + H2O
-
70.3% desaturation
-
-
?
cis-9-octadecenoic acid + reduced acceptor + O2
cis,cis-9,12-octadecadienoic acid + acceptor + 2 H2O
-
PtFAD2 is involved in the biosynthesis of eicosapentaenoic acid
-
-
?
cis-9-octadecenoic acid + reduced acceptor + O2
cis,cis-9,12-octadecadienoic acid + acceptor + 2 H2O
-
20.6% desaturation
-
-
?
cis-9-octadecenoic acid + reduced acceptor + O2
cis,cis-9,12-octadecadienoic acid + acceptor + 2 H2O
-
cis-9-octadecenoic acid is the most efficient substrate for PtFAD2, 50.3% desaturation
-
-
?
oleic acid + ?
linoleic acid + ?
-
DELTA12-desaturase mutant shows delayed spore germination, a twofold reduction in growth, a reduced level of conidiation and complete loss of sclerotial development, compared with the wild-type enzyme
-
-
?
oleic acid + ?
linoleic acid + ?
linoleic acid was detectable when expressing Fm2 in DELTA12 desaturase knockout Yarrowia lipolytica
-
-
?
oleic acid + ?
linoleic acid + ?
expression in Saccharomyces cerevisiae leads to endogenous production of linoleic acid
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
best substrate with 72% conversion
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
best substrate with 23% conversion
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
FAD2 introduces a double bond in position DELTA12 in oleic acid (18:1) to form linoleic acid (18:2 n-6)
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
specific substrate
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
specific substrate
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
best substrate with 63.3% conversion
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + alpha-linolenic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + alpha-linolenic acid + acceptor + H2O
-
-
-
-
?
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
oleoyl-CoA + 2 reduced acceptor + O2 + 2 H+
linoleoyl-CoA + 2 acceptor + 2 H2O
-
-
-
?
oleoyl-CoA + 2 reduced acceptor + O2 + 2 H+
linoleoyl-CoA + 2 acceptor + 2 H2O
-
-
-
?
oleoyl-CoA + reduced acceptor + O2
9,12-octadecadienoyl-CoA + acceptor + 2 H2O
-
-
-
-
?
oleoyl-CoA + reduced acceptor + O2
9,12-octadecadienoyl-CoA + acceptor + 2 H2O
-
-
-
?
oleoyl-CoA + reduced acceptor + O2
9,12-octadecadienoyl-CoA + acceptor + 2 H2O
-
-
-
?
oleoyl-CoA + reduced acceptor + O2
octadec-9,11-dienoyl-CoA + acceptor + 2 H2O
-
-
-
-
?
oleoyl-CoA + reduced acceptor + O2
octadec-9,11-dienoyl-CoA + acceptor + 2 H2O
-
the DELTA12 desaturase provides the key step for the cockroach to become nutritionally independent of dietary lipid and to synthesize eicosanoids de novo
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
-
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
43% conversion
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
-
-
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
-
4.1% conversion
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
-
26.7% conversion
-
-
?
stearolic acid + reduced acceptor + O2
trans-12-octadecen-9-ynoic acid + acceptor + H2O
-
4.8% conversion
-
-
?
stearolic acid + reduced acceptor + O2
trans-12-octadecen-9-ynoic acid + acceptor + H2O
-
35% conversion
-
-
?
additional information
?
-
-
oxygen availability alone can regulate de novo DELTA12-desaturase synthesis in Acanthamoeba castellanii and oxygen can limit the activity of preexisting DELTA12-desaturase
-
-
?
additional information
?
-
-
the main transition in fatty acid metabolism of Acanthamoeba castellanii during batch growth appears to be primarily related to a rapid decline in DELTA12-desaturase activity after 24 h. The resultant large growth-dependent changes in the degree of fatty acid unsaturation would be expected to affect the physical state and/or fluidity of membranes, and may be related to many of the distinctive physiological and biochemical characteristics displayed by Acanthamoeba castellanii in different stages of batch growth
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a processive bifunctional oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a processive bifunctional oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a processive bifunctional oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a strictly monofunctional oleoyl-DELTA12 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a strictly monofunctional oleoyl-DELTA12 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a strictly monofunctional oleoyl-DELTA12 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a processive bifunctional oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a processive bifunctional oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a strictly monofunctional oleoyl-DELTA12 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a strictly monofunctional oleoyl-DELTA12 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
the enzyme can also catalyze DELTA15 desaturation
-
-
?
additional information
?
-
recombinantly expressed enzyme CSFAD2A is a DELTA12 desaturase and has DELTAx+3 activity
-
-
?
additional information
?
-
the enzyme is a bifunctional fatty acid desaturase with both high DELTA12 desaturase activity and unusual DELTA15 desaturase activities
-
-
?
additional information
?
-
the enzyme is a bifunctional fatty acid desaturase with both high DELTA12 desaturase activity and unusual DELTA15 desaturase activities
-
-
?
additional information
?
-
the enzyme is a bifunctional fatty acid desaturase with both high DELTA12 desaturase activity and unusual DELTA15 desaturase activities
-
-
?
additional information
?
-
-
the DELTA12-desaturase enzymatic complex shows a preference towards oleoyl-CoA versus elaidoyl-CoA. Study of substrate specificity of the DELTA12 desaturase system is difficult due to the involvement of numerous enzymes. At least two activities are involved: in a first step, acyl CoA synthetase catalyzes the formation of oleoyl-CoA from olic acid and CoA, then oleoyl-CoA is desaturated into linoleoyl-CoA. No desaturation occurs when CoA is absent in the reaction medium
-
-
?
additional information
?
-
-
the DELTA12-desaturase enzymatic complex shows a preference towards oleoyl-CoA versus elaidoyl-CoA. Study of substrate specificity of the DELTA12 desaturase system is difficult due to the involvement of numerous enzymes. At least two activities are involved: in a first step, acyl CoA synthetase catalyzes the formation of oleoyl-CoA from olic acid and CoA, then oleoyl-CoA is desaturated into linoleoyl-CoA. No desaturation occurs when CoA is absent in the reaction medium
-
-
?
additional information
?
-
-
PtFAD6 is involved in the biosynthesis of hexadecantrienic acid
-
-
?
additional information
?
-
-
no activity with cis-13-docosenoic acid
-
-
?
additional information
?
-
-
synergistic effect of high-light and low temperature on cell growth of the DELTA12 fatty acid desaturase mutant
-
-
?
additional information
?
-
-
no activity with myristoleic acid palmitoleic acid, heptadecenoic acid, elaidic acid, linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, or docosatetraenoic acid
-
-
?
additional information
?
-
-
the enzyme has dual specificities of a DELTA12-fatty acid desaturase and a v+3-fatty acid desaturase
-
-
?
additional information
?
-
-
no activity with myristoleic acid palmitoleic acid, heptadecenoic acid, elaidic acid, linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, or docosatetraenoic acid
-
-
?
additional information
?
-
-
the enzyme has dual specificities of a DELTA12-fatty acid desaturase and a v+3-fatty acid desaturase
-
-
?
additional information
?
-
-
no activity with myristoleic acid palmitoleic acid, heptadecenoic acid, elaidic acid, linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, or docosatetraenoic acid
-
-
?
additional information
?
-
-
the enzyme has dual specificities of a DELTA12-fatty acid desaturase and a v+3-fatty acid desaturase
-
-
?
additional information
?
-
gene Ssd12 encodes a DELTA12-FAD, which can convert 16:1 and 18:1 into 16:2 and 18:2 fatty acids, substrate specificity, overview
-
-
?
additional information
?
-
-
gene Ssd12 encodes a DELTA12-FAD, which can convert 16:1 and 18:1 into 16:2 and 18:2 fatty acids, substrate specificity, overview
-
-
?
