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1.14.19.5: acyl-CoA 11-(Z)-desaturase

This is an abbreviated version!
For detailed information about acyl-CoA 11-(Z)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.5

Reaction

long-chain acyl-CoA
+
reduced acceptor
+
O2
=
DELTA11-acyl-CoA
+
acceptor
+ 2 H2O

Synonyms

(Z)-11 myristoyl CoA desaturase, acyl-CoA DELTA11-desaturase, acyl-CoA desaturase, acyl-CoA Z/E11 desaturase, APTQ desaturase, bifunctional DELTA11-desaturase, bifunctional Z-DELTA11-desaturase, Cro-Z/E11, CroDELTA11 desaturase, DELTA11 desaturase, DELTA11-(Z)-desaturase, DELTA11-desaturase, DELTA11-fatty-acid desaturase, DELTA11-myristoyl-CoA desaturase, DELTA11-palmitoyl-CoA-desaturase, DELTA11-palmitoyl-coenzyme A desaturase, desat1, desaturase, myristoly coenzyme A (E)-11, Dpu-DELTA11-APSQ, Dpu-DELTA11-LPAE, EC 1.14.99.32, fatty acid DELTA11-desaturase, fatty acyl DELTA11-desaturase, LATPG1, Lca-KPVQ, MambrD11-desaturase, More, myristoyl-CoA 11-(Z) desaturase, OfuZ/E11 protein, OscZ/E11 protein, PDesat-TnDELTA11 Z protein, Sls//E11, sphingolipid long chain base delta 8 desaturase, TpDESN, Z/E11-desaturase, Z/EDELTA11

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.5 acyl-CoA 11-(Z)-desaturase

Systematic Name

Systematic Name on EC 1.14.19.5 - acyl-CoA 11-(Z)-desaturase

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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (11,12 cis-dehydrogenating)
The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs. In moths the enzyme participates in the biosynthesis of their sex pheromones. The enzyme from the marine microalga Thalassiosira pseudonana is specific for palmitoyl-CoA (16:0) [4], that from the leafroller moth Choristoneura rosaceana desaturates myristoyl-CoA (14:0) [5], while that from the moth Spodoptera littoralis accepts both substrates [1]. The enzyme contains three histidine boxes that are conserved in all desaturases [2]. It is membrane-bound, and contains a cytochrome b5-like domain at the N-terminus that serves as the electron donor for the active site of the desaturase.