1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase
This is an abbreviated version!
For detailed information about 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase, go to the full flat file.
Word Map on EC 1.14.18.6
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1.14.18.6
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paraplegia
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sphingolipids
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2-hydroxylation
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leukodystrophy
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nbias
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atp13a2
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dystonia
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pla2g6
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paraparesis
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galactosylceramide
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sulfatide
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alpha-hydroxylation
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paucimobilis
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hydroxylase-associated
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medicine
- 1.14.18.6
- paraplegia
- sphingolipids
-
2-hydroxylation
- leukodystrophy
- nbias
-
atp13a2
- dystonia
- pla2g6
- paraparesis
- galactosylceramide
- sulfatide
-
alpha-hydroxylation
- paucimobilis
-
hydroxylase-associated
- medicine
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 +
Synonyms
FA2H, AtFAH1, FA2H, FAH1, fatty acid 2-hydroxylase, fatty acid 2-hydroxylase 1, fatty acid alpha-hydroxylase, SCS7, Scs7p, scScs7p, sphingolipid alpha-hydroxylase
ECTree
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Engineering
Engineering on EC 1.14.18.6 - 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase
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D323A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H173A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H244A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H249A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H264A
site-directed mutagenesis, the mutation results in unaltered syringomycin E sensitivity compared to the wild-type
H268A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H271A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H272A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H326A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H330A
site-directed mutagenesis, the mutation results in complete loss of syringomycin E sensitivity
H331A
site-directed mutagenesis, the mutation results in unaltered syringomycin E sensitivity compared to the wild-type
H345A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H348A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H349A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
Y319A
site-directed mutagenesis, the mutation results in unaltered syringomycin E sensitivity compared to the wild-type
Y322A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
additional information
FA2H lacking the N-terminal cytochrome b5 domain has little activity
additional information
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FA2H lacking the N-terminal cytochrome b5 domain has little activity
additional information
generation of an scs7-DELTA strain from wild-type Saccharomyces cerevisiae strain BY4742. The model of DELTA95scScs7p mutant is inserted into a pre-equilibrated lipid bilayer comprised of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
additional information
-
generation of an scs7-DELTA strain from wild-type Saccharomyces cerevisiae strain BY4742. The model of DELTA95scScs7p mutant is inserted into a pre-equilibrated lipid bilayer comprised of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine