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1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

This is an abbreviated version!
For detailed information about 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase, go to the full flat file.

Word Map on EC 1.14.18.6

Reaction

a phytoceramide
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a (2'R)-2'-hydroxyphytoceramide
+ 2 ferricytochrome b5 +
H2O

Synonyms

FA2H, AtFAH1, FA2H, FAH1, fatty acid 2-hydroxylase, fatty acid 2-hydroxylase 1, fatty acid alpha-hydroxylase, SCS7, Scs7p, scScs7p, sphingolipid alpha-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.6 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

Activating Compound

Activating Compound on EC 1.14.18.6 - 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Bax inhibitor-1
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from Arabidopsis thaliana, BI-1 (AtBI-1) protein interacts with the enzyme. Bax inhibitor-1 is a widely conserved cell death suppressor localized in the endoplasmic reticulum membrane. AtBI-1 binds cytochrome b5-like domain-containing proteins like fatty acid 2-hydroxylase 1
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